Cch1p Mediates Ca2+ Influx to Protect Saccharomyces cerevisiae against Eugenol Toxicity

PLoS ONE

Volumn 7, Issue 9, 2012, Pages

  Roberts, Stephen K ^a   McAinsh, Martin ^b   Widdicks, Lisa ^a  

^a LANCASTER UNIVERSITY   (United Kingdom)

^b LANCASTER UNIVERSITY   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

AEQUORIN; CALCIUM CHANNEL; CALCIUM ION; CCH1P PROTEIN; EUGENOL; MID1P PROTEIN; UNCLASSIFIED DRUG; YVC1P PROTEIN; ANTIFUNGAL AGENT; CALCIUM; CCH1 PROTEIN, S CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEIN;

ANTIFUNGAL ACTIVITY; ARTICLE; CALCIUM CELL LEVEL; CALCIUM HOMEOSTASIS; CALCIUM TRANSPORT; CELL MEMBRANE TRANSPORT; CONTROLLED STUDY; CYTOSOL; FUNGUS GROWTH; INTRACELLULAR SIGNALING; NONHUMAN; SACCHAROMYCES CEREVISIAE; CALCIUM SIGNALING; DRUG EFFECT; DRUG TOLERANCE; GENETICS; METABOLISM; MUTATION;

FUNGI; SACCHAROMYCES CEREVISIAE;

ANTIFUNGAL AGENTS; CALCIUM; CALCIUM CHANNELS; CALCIUM SIGNALING; DRUG TOLERANCE; EUGENOL; MUTATION; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS;

EID: 84866414185     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0043989     Document Type: Article

References (31)

1. Monk BC, Goffeau A, (2008) Outwitting multidrug resistance to antifungals. Science 321: 367-369.
2. Bakkali F, Averbeck S, Averbeck D, Waomar M, (2008) Biological effects of essential oils- A review. Food and Chemical Toxicology 46: 446-475.
3. Ahmad A, Khan A, Khan LA, Manzoor N, (2010) In vitro synergy of eugenol and methyleugenol with fluconazole against clinical Candida isolates. Journal of Medical Microbiology 59: 1178-1184.
4. Zore GB, Thakre AD, Jadhav S, Karuppayil SM, (2011) Terpenoids inhibit Candida albicans growth by affecting membrane integrity and arrest of cell cycle. Phytomedicine 18: 1181-1190.
5. Rao A, Zhang YQ, Muend S, Rao R, (2010) Mechanism of Antifungal Activity of Terpenoid Phenols Resembles Calcium Stress and Inhibition of the TOR Pathway. Antimicrobial Agents and Chemotherapy 54: 5062-5069.
6. Fischer M, Schnell N, Chattaway J, Davies P, Dixon G, et al. (1997) The Saccharomyces cerevisiae CCH1 gene is involved in calcium influx and mating. Febs Letters 419: 259-262.
7. Gietz D, Woods RA, (1998) Transformation of yeast by the lithium acetate single-stranded carrier DNA/PEG method. Yeast Gene Analysis 26: 53-66.
8. Batiza AF, Schulz T, Masson PH, (1996) Yeast respond to hypotonic shock with a calcium pulse. J Biol Chem 271: 23357-23362.
9. Loukin S, Zhou XL, Kung C, Saimi Y, (2008) A genome-wide survey suggests an osmoprotective role for vacuolar Ca2+ release in cell wall-compromised yeast. Faseb Journal 22: 2405-2415.
10. Iida H, Nakamurah H, Ono T, Okumura MS, Anraku Y, (1994) MID1, a novel Saccharomyces cerevisiae gene encoding a plasma membrane protein required for Ca2+ influx and mating. Molecular and Cellular Biology 14: 8259-8271.
11. Locke EG, Bonilla M, Liang L, Takita Y, Cunningham KW, (2000) A homolog of voltage-gated Ca2+ channels stimulated by depletion of secretory Ca2+ in yeast. Molecular and Cellular Biology 20: 6686-6694.
12. Hong MP, Vu K, Bautos J, Gelli A, (2010) Cch1 Restores Intracellular Ca2+ in Fungal Cells during Endoplasmic Reticulum Stress. J Biol Chem 285: 10951-10958.
13. Muend S, Rao R, (2008) Fungicidal activity of amiodarone is tightly coupled to calcium influx. Fems Yeast Research 8: 425-431.
14. Loukin SH, Su ZW, Kung C, (2009) Hypotonic shocks activate rat TRPV4 in yeast in the absence of polyunsaturated fatty acids. Febs Letters 583: 754-758.
15. Sen Gupta S, Ton VK, Beaudry V, Rulli S, Cunningham K, et al. (2003) Antifungal activity of amiodarone is mediated by disruption of calcium homeostasis. J Biol Chem 278: 28831-28839.
16. Loukin SH, Kung C, Saimi Y, (2007) Lipid perturbations sensitize osmotic down-shock activated Ca2+ influx, a yeast "deletome" analysis. FASEB J 21: 1813-1820.
17. Courchesne WE, Ozturk S, (2003) Amiodarone induces a caffeine-inhibited, MID1-depedent rise in free cytoplasmic calcium in Saccharomyces cerevisiae. Molecular Microbiology 47: 223-234.
18. Palmer CP, Zhou XL, Lin JY, Loukin SH, Kung C, et al. (2001) A TRP homolog in Saccharomyces cerevisiae forms an intracellular Ca2+-permeable channel in the yeast vacuolar membrane. Proceedings Of The National Academy Of Sciences Of The United States Of America 98: 7801-7805.
19. Bonilla M, Nastase KK, Cunningham KW, (2002) Essential role of calcineurin in response to endoplasmic reticulum stress. Embo Journal 21: 2343-2353.
20. Denis V, Cyert MS, (2002) Internal Ca2+ release in yeast is triggered by hypertonic shock and mediated by a TRP channel homologue. Journal Of Cell Biology 156: 29-34.
21. Peiter E, Fischer M, Sidaway K, Roberts SK, Sanders D, (2005) The Saccharomyces cerevisiae Ca2+ channel Cch1pMid1p is essential for tolerance to cold stress and iron toxicity. Febs Letters 579: 5697-5703.
22. Kaur R, Castano I, Cormack BP, (2004) Functional genomic analysis of fluconazole susceptibility in the pathogenic yeast Candida glabrata: Roles of calcium signaling and mitochondria. Antimicrobial Agents and Chemotherapy 48: 1600-1613.
23. Reedy JL, Filler SG, Heitman J, (2010) Elucidating the Candida albicans calcineurin signaling cascade controlling stress response and virulence. Fungal Genetics And Biology 47: 107-116.
24. Liu M, Du P, Heinrich G, Cox GM, Gelli A, (2006) Cch1 mediates calcium entry in Cryptococcus neoformans and is essential in low-calcium environments. Eukaryotic Cell 5: 1788-1796.
25. Brand A, Shanks S, Duncan VMS, Yang M, Mackenzie K, et al. (2007) Hyphal orientation of Candida albicans is regulated by a calcium-dependent mechanism. Current Biology 17: 347-352.
26. Edlind T, Smith L, Henry K, Katiyar S, Nickels J, (2002) Antifungal activity in Saccharomyces cerevisiae is modulated by calcium signalling. Molecular Microbiology 46: 257-268.
27. Maresova L, Muend S, Zhang YQ, Sychrova H, Rao R, (2009) Membrane Hyperpolarization Drives Cation Influx and Fungicidal Activity of Amiodarone. J Biol Chem 284: 2795-2802.
28. Yoo CB, Han KT, Cho KS, Ha J, Park HJ, et al. (2005) Eugenol isolated from the essential oil of Eugenia caryophyllata induces a reactive oxygen species-mediated apoptosis in HL-60 human promyelocytic leukemia cells. Cancer Letters 225: 41-52.
29. Pinontoan R, Krystofova S, Kawano T, Mori IC, Tsuji FI, et al. (2002) Phenylethylamine induces an increase in cytosolic Ca2+ in yeast. Bioscience Biotechnology and Biochemistry 66: 1069-1074.
30. Popa CV, Dumitru I, Ruta LL, Danet AF, Farcasanu IC, (2010) Exogenous oxidative stress induces Ca2+release in the yeast Saccharomyces cerevisiae. Febs Journal 277: 4027-4038.
31. Martin DC, Kim H, Mackin NA, Maldonado-Baez L, Evangelista CC, et al. (2011) New Regulators of a High Affinity Ca2+ Influx System Revealed through a Genome-wide Screen in Yeast. J Biol Chem 286: 10744-10754.