TLR4 regulates cardiac lipid accumulation and diabetic heart disease in the nonobese diabetic mouse model of type 1 diabetes

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 303, Issue 6, 2012, Pages

  Dong, Baojun ^a   Qi, Dake ^a   Yang, Long ^a   Huang, Yan ^a   Xiao, Xiaoyan ^a,b   Tai, Ningwen ^a   Wen, Li ^a   Susan Wong, F ^a,c  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b SHANDONG UNIVERSITY   (China)

^c CARDIFF UNIVERSITY   (United Kingdom)

Author keywords

Cardiac complications; Diabetes; Nonobese diabetic mice; Toll like receptor 4

Indexed keywords

ACETYL COENZYME A CARBOXYLASE; ADENYLATE KINASE; FATTY ACID; GLUCOSE; LIPID; LIPOPROTEIN LIPASE; MITOGEN ACTIVATED PROTEIN KINASE P38; MYELOID DIFFERENTIATION FACTOR 88; OLEIC ACID; PHOSPHOPROTEIN; SMALL INTERFERING RNA; STRESS ACTIVATED PROTEIN KINASE; TOLL LIKE RECEPTOR 4; TRIACYLGLYCEROL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY WEIGHT; CONTROLLED STUDY; DIABETIC CARDIOMYOPATHY; ECHOCARDIOGRAPHY; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; EXPERIMENTAL MODEL; FATTY ACID BLOOD LEVEL; FATTY ACID METABOLISM; FEMALE; GENE; GENOTYPE; GLUCOSE BLOOD LEVEL; HEART CONTRACTION; HEART EJECTION FRACTION; HEART FUNCTION; HEART LEFT VENTRICLE PRESSURE; HEART MUSCLE CELL; HEART WEIGHT; IMMUNOFLUORESCENCE MICROSCOPY; INSULIN DEPENDENT DIABETES MELLITUS; LIPID STORAGE; MOUSE; MYELOID DIFFERENTIATION FACTOR 88 GENE; NONHUMAN; NONOBESE DIABETIC MOUSE; PATHOGENESIS; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; RECEPTOR UPREGULATION; TRIACYLGLYCEROL BLOOD LEVEL; WILD TYPE;

AMP-ACTIVATED PROTEIN KINASES; ANIMALS; BLOOD GLUCOSE; CELL LINE; DIABETES MELLITUS, TYPE 1; DIABETIC CARDIOMYOPATHIES; DISEASE MODELS, ANIMAL; FATTY ACIDS, NONESTERIFIED; JNK MITOGEN-ACTIVATED PROTEIN KINASES; LIPID METABOLISM; LIPOPROTEIN LIPASE; MICE; MICE, INBRED C57BL; MICE, INBRED NOD; MICE, KNOCKOUT; MYELOID DIFFERENTIATION FACTOR 88; MYOCARDIUM; MYOCYTES, CARDIAC; OLEIC ACID; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; RATS; RNA INTERFERENCE; TIME FACTORS; TOLL-LIKE RECEPTOR 4; TRIGLYCERIDES;

EID: 84866410100     PISSN: 03636135     EISSN: 15221539     Source Type: Journal    
DOI: 10.1152/ajpheart.00948.2011     Document Type: Article

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