MicroRNAs related to angiogenesis are dysregulated in endometrioid endometrial cancer

Human Reproduction

Volumn 27, Issue 10, 2012, Pages 3036-3045

  Ramón, Luis A ^a   Braza Boïls, Aitana ^a   Gilabert, Juan ^b   Chirivella, Melitina ^a   España, Francisco ^a   Estellés, Amparo ^a   Gilabert Estellés, Juan ^c  

^a HOSPITAL UNIVERSITARIO LA FE   (Spain)

^b HOSPITAL ARNAU DE VILANOVA   (Spain)

^c HOSPITAL GENERAL UNIVERSITARIO DE VALENCIA   (Spain)

Author keywords

angiogenesis; endometrial cancer; microRNA; TSP 1; VEGF A

Indexed keywords

MICRORNA; MICRORNA 125A; MICRORNA 15B; MICRORNA 16; MICRORNA 200B; MICRORNA 20A; MICRORNA 21; MICRORNA 210; MICRORNA 214; MICRORNA 221; MICRORNA 222; MICRORNA 424; THROMBOSPONDIN 1; UNCLASSIFIED DRUG; VASCULOTROPIN A;

ADULT; AGED; ANGIOGENESIS; ARTICLE; CASE CONTROL STUDY; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE ASSOCIATION; DOWN REGULATION; ENDOMETRIUM CANCER; FEMALE; HUMAN; HUMAN TISSUE; PROTEIN EXPRESSION; RNA ANALYSIS; RNA ISOLATION;

EID: 84866395349     PISSN: 02681161     EISSN: 14602350     Source Type: Journal    
DOI: 10.1093/humrep/des292     Document Type: Article

References (66)

1. Alaiti MA, Ishikawa M, Masuda H, Simon Dl, Jain MK, Asahara T, Costa MA. Up-regulation of miR-21O by vascular endothelial growth factor in ex vivo expanded CD34+ cells enhances cell-mediated angiogenesis. J Cell Mol Med 2012, doi:l0.1111/j.1582-4934.2012.O1557.x.
2. Ambros V. The functions of animal microRNAs. Nature 2004;431: 350-355.
3. Bartel DP. MicroRNAs: genomics, biogenesis, mechanism, and function. Cell 2004;116:281-297.
4. Bartel DP. MicroRNAs: target recognition and regulatory functions. Cell 2009; 136:215-233.
5. Boren T, Xiong Y, Hakam A, Wenham R, Apte S, Wei Z, Kamath S, Chen DT, Dressman H, Lancaster JM. MicroRNAs and their target messenger RNAs associated with endometrial carcinogenesis. Gynecol Oncol 2008; 110:206-215.
6. Caporali A, Emanueli C. MicroRNA regulation in angiogenesis. Vascul Pharmacol 201l;55:79-86.
7. Carmeliet P. Angiogenesis in health and disease. Nat Med 2003; 9:653-660.
8. Chamorro-Jorganes A, Araldi E, Penalva LO, Sandhu D, Fernández- Hernando C, Suárez Y. MicroRNA-16 and microRNA-424 regulate cell-autonomous angiogenic functions in endothelial cells via targeting vascular endothelial growth factor receptor-2 and fibroblast growth factor receptor-1. Arterioscler Thromb Vase Biol 2011;3 I: 2595-2606.
9. Choi YC, Yoon S, Jeong Y, Yoon J, Baek K. Regulation of vascular endothelial growth factor signaling by miR-200b. Mol Cells 2011; 32:77-82.
10. Chung TK, Cheung TH, Huen NY, Wong KW, Lo KW, Yim SF, Siu NS, Wong YM, Tsang PT, Pang MW et al. Dysregulated microRNAs and their predicted targets associated with endometrioid endometrial adenocarcinoma in Hong Kong women. Int J Cancer 2009; 124: 358-1365.
11. Cohn DE, Fabbri M, Valeri N, Alder H, Ivanov I, Liu CG, Croce CM, Resnick KE. Comprehensive miRNA profiling of surgically staged endometrial cancer. Am J Obstet Gynecol 2010;202:656.el-656.e8.
12. Devor EJ, Hovey AM, Goodheart MJ, Ramachandran S, Leslie KK. microRNA expression profiling of endometrial endometrioid adenocarcinomas and serous adenocarcinomas reveals profiles containing shared, unique and differentiating groups of microRNAs. Onco/Rep 2011;26:995-1002.
13. Dews M, Homayouni A, Yu D, Murphy D, Sevignani C, Wentzel E, Furth EE, Lee WM, Enders GH, Mendell JT et al. Augmentation of tumor angiogenesis by a Myc-activated microRNA cluster. Nat Genet 2006;38:1060-1065.
14. Doebele C, Bonauer A, Fischer A, Scholz A, Reiss Y, Urbich C, Hofmann WK, Zeiher AM, Dimmeler S. Members of the microRNA-17-92 cluster exhibit a cell-intrinsic antiangiogenic function in endothelial cells. Blood 2010;115:4944-4950.
15. Fish JE, Srivastava D. MicroRNAs: opening a new vein in angiogenesis research. Sci Signal 2009;2:pe I.
16. Gilabert-Estellés J, Estellés A, Gilabert J, Castelló R, España F, Falcó C, Romeu A, Chirivella M, Zorio E, Aznar J. Expression of several components of the plasminogen activator and matrix metalloproteinase systems in endometriosis. Hum Reprod 2003; 18:1516-1522.
17. Gilabert-Estellés J, Ramon LA, España F, Gilabert J, Vila V, Réganon E, Castelló R, Chirivella M, Estellés A. Expression of angiogenic factors in endometriosis: its relation to fibrinolytic and metalloproteinase (MMP) systems. Hum Reprod 2007;22:2120-2127.
18. Gilabert-Estellés J, Braza-Boils A, Ramon LA, Zorio E, Medina P, España F, Estellés A. Role of microRNAs in gynecological pathology. Curr Med Chem 2012; 19:2406-2413.
19. Götte M, Mohr C, Koo CY, Stock C, Vaske AK, Viola M, Ibrahim SA, Peddibhotla S, Teng YH, Low JY et al. miR-145-dependent targeting of junctional adhesion molecule A and modulation of fascin expression are associated with reduced breast cancer cell motility and invasiveness. Oncogene 2010;29:6569-6580.
20. Gregory PA, Bracken CP, Bert AG, Goodall GJ. MicroRNAs as regulators of epithelial-mesenchymal transition. Cell Cycle 2008;7:3112-3118.
21. Guo X, Wu Y, Hartley RS. MicroRNA-125a represses cell growth by targeting HuR in breast cancer. RNA Biol 2009;6:575-583.
22. Hiroki E, Akahira J, Suzuki F, Nagase S, Ito K, Suzuki T, Sasano H, Yaegashi N. Changes in microRNA expression levels correlate with clinicopathological features and prognoses in endometrial serous adenocarcinomas. Cancer Sci 2010; 101:241-249.
23. Hua Z, Lv Q, Ye W, Wong CK, Cai G, Gu D, Ji Y, Zhao C, Wang J, Yang BB et al. MiRNA-directed regulation of VEGF and other angiogenic factors under hypoxia. PLoS One 2006;1:e116.
24. Ibberson D, Benes V, Muckenthaler MLJ, Castoldi M. RNA degradation compromises the reliability of microRNA expression profiling. BMC Biotechnol 2009;9:1022.
25. Lorio MV, Visone R, Di Leva G, Donati V, Petrocca F, Casalini P, Taccioli C, Volinia S, Liu CG, Alder H et al. MicroRNA signatures in human ovarian cancer. Cancer Res 2007;67:8699-8707.
26. Jemal A, Siegel R, Xu J, Ward E. Cancer statistics. CA Cancer J Clin 2010; 60:277-300.
27. Kamat AA, Merritt WM, Coffey D, Lin YG, Patel PR, Broaddus R, Nugent E, Han LY, Landen CN Jr, Spannuth WA et al. Clinical and biological significance of vascular endothelial growth factor in endometrial cancer. Clin Cancer Res 2007; 13:7487-7495.
28. Karaa ZS, lacovoni JS, Bastide A, Lacazette E, Touriol C, Prats H. The VEGF IRESes are differentially susceptible to translation inhibition by miR-16. RNA 2009; 15:249-254.
29. Kawano Y, Nakamura S, Nasu K, Fukuda J, Narahara H, Miyakawa I. Expression and regulation of thrombospondin-1 by human endometrial stromal cells. Fertil Steril 2005;83:1056-1059.
30. Korpal M, Kang Y The emerging role of miR-200 family of microRNAs in epithelial-mesenchymal transition and cancer metastasis. RNA Biol 2008; 5:115-119.
31. Kuokkanen S, Chen B, Ojalvo L, Benard L, Santoro N, Pollard JW. Genomic profiling of microRNAs and messenger RNAs reveals hormonal regulation in microRNA expression in human endometrium. Biol Reprod 2010;82:79l-801.
32. Kurman RJ, Zaino RJ, Norris HJ. Endometrial carcinoma. In: Kurman RJ (ed). Blaustein's Pathology of the Female Genital Tract. New York, USA: Springer, 1994, 439-486.
33. Lam EW, Shah K, Brosens J. The role of microRNAs and FOXO transcription factors in cycling endometrium and cancer. J Endocrinol 2012;212:13-25.
34. Le XF, Merchant O, Bast RC, Calin GA The roles of MicroRNAs in the cancer invasion-metastasis cascade. Cancer Microenviron 2010; 3:137-147.
35. Lee JW, Park YA, Choi JJ, Lee YY, Kim CJ, Choi C, Kim TJ, Lee NW, Kim BG, Bae DS. The expression of the miRNA-200 family in endometrial endometrioid carcinoma. Gynecol Oncol 2011; 120:56-62.
36. Li Y, Song YH, Li F, Yang T, Lu YW, Geng YJ. MicroRNA-22l regulates high glucose-induced endothelial dysfunction, Biochem Biophys Res Commun 2009;381:81-83.
37. Liu LZ, Li C, Chen Q, Jing Y, Carpenter R, Jiang Y, Kung HF, Lai L, Jiang BH. MiR-21 induced angiogenesis through AKT and ERK activation and HIF-1 a expression. PLoS One 2011;6:e19139.
38. Liu F, Lou YL, Wu J, Ruan QF, Xie A, Guo F, Cui SP, Deng ZF, Wang Y. Upregulation of MicroRNA-210 regulates renal angiogenesis mediated by activation of VEGF signaling pathway under ischemia/perfusion injury in vivo and in vitro. Kidney Blood Press Res 2012; 35:182-191.
39. Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. J. Methods 2001;25:402-408.
40. McLaren J. Vascular endothelial growth factor and endometriotic angiogenesis. Hum Reprod Update 2000;6:45-55.
41. Mendell JT. miRiad roles for the miR-17-92 cluster in development and disease. Cell 2008; 133:217-222.
42. Nam EJ, Yoon H, Kim SW, Kim H, Kim YT, Kim JH, Kim JW, Kim S. MicroRNA expression profiles in serous ovarian carcinoma. Clin Cancer Res 2008; 14:2690-2695.
43. Ng EK, Wong CL, Ma ES, Kwong A. MicroRNAs as new players for diagnosis, prognosis, and therapeutic targets in breast cancer. J Oncol 2009;2009:305-420.
44. Nicoloso MS, Spizzo R, Shimizu M, Rossi S, Calin GA. MicroRNAs\the micro steering wheel of tumour metastases. Nat Rev Cancer 2009; 9:293-302.
45. Nishida N, Mimori K, Fabbri M, Yokobori T, Sudo T, Tanaka F, Shibata K, Ishii H, Doki Y, Mori M. MicroRNA-125a-5p is an independent prognostic factor in gastric cancer and inhibits the proliferation of human gastric cancer cells in combination with trastuzumab. Clin Cancer Res 2011; 17:2725-2733.
46. O'Day E, Lai A. MicroRNAs and their target gene networks in breast cancer, Breost Cancer Res 2010; 12:201.
47. Ohlsson Teague E, Van der Hoek K, Van der Hoek M, Perry N, Wagaarachchi P, Robertson S, Print C, Hull L. MicroRNA-regulated pathways associated with endometriosis. Mol Endocrinol 2009; 23:265-275.
48. Pan Q, Chegini N. MicroRNA signature and regulatory functions in the endometrium during normal and disease states. Semin Reprod Med 2008;26:479-493.
49. Panda H, Pelakh L, Chuang TD, Luo X, Bukulmez O, Chegini N. Endometrial miR-200c is altered during transformation into cancerous states and targets the expression of ZEBs, VEGFA, FLTI, IKKβ, KLF9, and FBLN5. Reprod Sci 2012. [Epub ahead of print].
50. Pecorelli S. Revised FIGO staging for carcinoma of the vulva, cervix, and endometrium. Int J Gynaecol Obstet 2009;105:103-104.
51. Poliseno L, Tuccoli A, Mariani L, Evangelista M, Citti L, Woods K, Mercatanti A, Hammond S, Rainaldi G. MicroRNAs modulate the angiogenic properties of HUVECs. Blood 2006; 108:3068-3071.
52. Ramon LA, Braza-Boïls A, Gilabert-Estellés J, Gilabert J, España F, Chirivella M, Estellés A. microRNAs expression in endometriosis and their relation to angiogenic factors. Hum Reprod 2011;26:1082-1090.
53. Ratner ES, Tuck D, Richter C, Nallur S, Patel RM, Schultz V, Hui P, Schwartz PE, Rutherford TJ, Weidhaas JB. MicroRNA signatures differentiate uterine cancer tumor subtypes. Gynecol Oncol 2010; 118:251-257.
54. Seki N, Kodama J, Hashimoto I, Hongo A, Yoshinouchi M, Kudo T. Thrombospondin-1 and-2 messenger RNA expression in normal and neoplastic endometrial tissues: correlation with angiogenesis and prognosis. Intl Oncol 2001; 19:305-310.
55. Shenouda SK, Alahari SK. MicroRNA function in cancer: oncogene or a tumor suppressor? Cancer Metastasis Rev 2009;28:369-378.
56. Snowdon J, Zhang X, Childs T, Tron VA, Feilotter H. The microRNA-200 family is upregulated in endometrial carcinoma. PLoS One 2011; 6:e22828.
57. Sonkoly E, Pivarcsi A. microRNAs in inflammation. Int Rev Immunol 2009; 28:535-561.
58. Suarez Y, Sessa WC. MicroRNAs as novel regulators of angiogenesis. Ore Res 2009; 104:442-454.
59. Suárez Y, Fernández-Hernando C, Yu J, Gerber SA, Harrison KD, Pober JS, Iruela-Arispe ML, Merkenschlager M, Sessa WC. Dicer-dependent endothelial microRNAs are necessary for postnatal angiogenesis. Proc Natl Acad Sci USA 2008; 105:14082-14087.
60. Talvensaari-Mattila A, Soini Y, Santala M. VEGF and its receptors (fit-1 and KDR/flk-l) as prognostic indicators in endometrial carcinoma. Tumour Biol 2005;26:8l-7.
61. Urbich C, Kuehbacher A, Dimmeler S. Role of microRNAs in vascular diseases, inflammation, and angiogenesis. Cardiovasc Res 2008;79:581-588.
62. van Mil A, Grundmann S, Goumans MJ, Lei Z, Oerlemans Ml, Jaksani S, Doevendans PA, Sluijter JP. MicroRNA-214 inhibits angiogenesis by targeting quaking and reducing angiogenic growth factor release. Cardiovasc Res 2012;93:655-665.
63. Wang S, Olson EN. Angiomi Riskey regulators of angiogenesis. Curr Opin Genet Dev 2009;19:205-211.
64. Wu F, Yang Z, Li G. Role of specific microRNAs for endothelial function and angiogenesis. Biochem Biophys Res Commun 2009a;4:549-553.
65. Wu W, Lin Z, Zhuang Z, Liang X. Expression profile of mammalian microRNAs in endometrioid adenocarcinoma. Eur J Cancer Prev 2009b; 18:50-55.
66. Zorio E, Medina P, Rueda J, Millán JM, Arnau MA, Beneyto M, Marín F, Gimeno JR, Osca J, Salvador A et al. Insights of the role of microRNAs in cardiac diseases: from biological signaling to therapeutic targets. Cardiovas Hematol Agent Med Chem 2009;7:82-90.