Neuronal expression of F-box and leucine-rich-repeat protein 2 decreases over braak stages in the brains of Alzheimer's disease patients

Neurodegenerative Diseases

Volumn 11, Issue 1, 2012, Pages 1-12

  Watanabe, Tomomichi ^a   Von Der Kammer, Heinz ^b   Wang, Xiaolu ^b   Shintani, Yasushi ^a   Horiguchi, Takashi ^a  

^a TAKEDA PHARMACEUTICAL COMPANY LIMITED   (Japan)

^b EVOTEC AG   (Germany)

Author keywords

Alzheimer's disease; Apolipoprotein E4; F box and leucine rich repeat protein 2; Neuronal expression; Ubiquitin proteasome system

Indexed keywords

APOLIPOPROTEIN E4; F BOX PROTEIN; LEUCINE RICH REPEAT KINASE 2; LEUCINE RICH REPEAT PROTEIN 2; MESSENGER RNA; PROTEASOME; UBIQUITIN; UNCLASSIFIED DRUG;

ALLELE; ALZHEIMER DISEASE; ARTICLE; ASTROCYTE; BRAIN NERVE CELL; CONTROLLED STUDY; DENDRITE; FRONTAL CORTEX; HUMAN; HUMAN TISSUE; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; MICROGLIA; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; TEMPORAL CORTEX;

AGED; AGED, 80 AND OVER; ALZHEIMER DISEASE; APOLIPOPROTEIN E4; BRAIN; CASE-CONTROL STUDIES; DISEASE PROGRESSION; EXCITATORY AMINO ACID TRANSPORTER 1; F-BOX PROTEINS; FEMALE; GENE EXPRESSION REGULATION; HEK293 CELLS; HUMANS; MALE; MICROTUBULE-ASSOCIATED PROTEINS; MIDDLE AGED; NERVE TISSUE PROTEINS; NEUROGLIA; NEURONS; POSTMORTEM CHANGES; PSYCHIATRIC STATUS RATING SCALES; RNA, MESSENGER; TRANSFECTION;

EID: 84866394478     PISSN: 16602854     EISSN: 16602862     Source Type: Journal    
DOI: 10.1159/000336016     Document Type: Article

References (25)

1. Hershko A, Ciechanover A, Varshavsky A: Basic Medical Research Award: the ubiquitin system. Nat Med 2000; 6: 1073-1081.
2. Bedford L, Lowe J, Dick LR, Mayer RJ, Brownell JE: Ubiquitin-like protein conjugation and the ubiquitin-proteasome system as drug targets. Nat Rev Drug Discov 2011; 10: 29-46.
3. Perry G, Rizzuto N, Utilio-Gambetti L, Gambetti P: Paired helical filaments from Alzheimer disease patients contain cytoskeletal components. Proc Natl Acad Sci USA 1985; 82: 3916-3920. (Pubitemid 15246464)
4. Alves-Rodrigues A, Gregori L, Figueiredo- Pereira ME: Ubiquitin, cellular inclusions and their role in neurodegeneration. Trends Neurosci 1998; 21: 516-520. (Pubitemid 28555693)
5. Chen L, Thiruchelvam MJ, Madura K, Richfield EK: Proteasome dysfunction in aged human alpha-synuclein transgenic mice. Neurobiol Dis 2006; 23: 120-126. (Pubitemid 43903635)
6. Ortega Z, Díaz-Hernández M, Maynard CJ, Hernández F, Dantuma NP, Lucas JJ: Acute polyglutamine expression in inducible mouse model unravels ubiquitin/proteasome system impairment and permanent recovery attributable to aggregate formation. J Neurosci 2010; 10: 3675-3688.
7. Perry G, Friedman R, Shaw G, Chau V: Ubiquitin is detected in neurofibrillary tangles and senile plaque neuritis of Alzheimer disease brains. Proc Natl Acad Sci USA 1987; 84: 3033-3036. (Pubitemid 17064772)
8. Fred W, van Leeuwen, Dominique PV, de Kleijn Helma H, van den Hurk, Andrea Neubauer, Marc AF, Sonnemans Jacqueline A Sluijs, Soner Koycu, Ravindra DJ, Ramdjielal Ahmad Salehi, Gerard JM, Martens, Frank G, Grosveld, J, Peter H, Burbacj, Elly M Hol: Frameshift mutants of-amyloid precursor protein and ubiquitin-B in Alzheimer's and Down patients. Science 1998; 279: 242-247. (Pubitemid 28103884)
9. Lam YA, Pickart CM, Alban A, London M, Jamieson C, Ramage R, Mayer RJ, Layfield R: Inhibition of the ubiquitin-proteasome system in Alzheimer's disease. Proc Natl Acad Sci USA 2000; 97: 9902-9906.
10. Tan Z, Sun X, Hou FS, Oh HW, Hilgenberg LG, Hol EM, van Leeuwen FW, Smith MA, O'Dowd DK, Schreiber SS: Mutant ubiquitin found in Alzheimer's disease causes neuritic beading of mitochondria in association with neuronal degeneration. Cell Death Differ 2007; 10: 1721-1732. (Pubitemid 47423640)
11. Kitada T, Asakawa S, Hattori N, Matsumine H, Yamaura Y, Minoshima S, Yokochi M, Mizuno Y, Shimizu N: Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism. Nature 1998; 392: 605-608. (Pubitemid 28207717)
12. Shimura H, Hattori N, Kubo S, Mizuno Y, Asakawa S, Minoshima S, Shimizu S, Iwai K, Chiba T, Tanaka K, Suzuki T: Familial Parkinson disease gene product, parkin, is a ubiquitin-protein ligase. Nat Genet 2000; 25: 302-305. (Pubitemid 30437317)
13. Feldmann RM, Correll CC, Kaplan KB, Deshaies RJ: A complex of Cdc4p, Skp1p, and Cdc53p/cullin catalyzes ubiquitination of the phosphorylated CDK inhibitor Sic1p. Cell 1997; 91: 221-230. (Pubitemid 27456389)
14. Lechner E, Achard P, Vansiri A, Potuschak T, Genschik P: F-box proteins everywhere. Curr Opin Plant Biol 2006; 9: 631-638. (Pubitemid 44537838)
15. Ilyin G, Rialland M, Glaise D, Guguen-Guillouz C: Identification of a novel Skp2-like mammalian protein containing F-box and leucine-rich repeats. FEBS Lett 1999; 459: 75-79. (Pubitemid 29447658)
16. Cardozo T, Pagano M: The SCF ubiquitin ligase: insights into a molecular machine. Nat Rev Mol Cell Biol 2004; 5: 739-751. (Pubitemid 39208183)
17. Kobe B, Kajava AV: The leucine-rich repeat as a protein recognition motif. Curr Opin Struct Biol 2001; 11: 725-732. (Pubitemid 34076634)
18. Terry RD, Peck A, DeTeresa R, Schechter R, Horoupian DS: Some morphometric aspects of the brain in senile dementia of the Alz heimer type. Ann Neurol 1981; 10: 184-192. (Pubitemid 11053105)
19. Bales KR, Dodart JC, DeMattos RB, Holtzmen DM, Paul SM: Apolipoprotein E, amyloid, and Alzheimer disease. Mol Interv 2002; 2: 363-375.
20. Corder EH, Saunders AM, Strittmatter WJ, Schmechel DE, Gaskell PC, Small GW, Roses AD, Haines JL, Pericak-Vance MA: Gene dose of apolipoprotein E type4 allele and the risk of Alzheimer's disease in late onset families. Science 1993; 261: 921-923. (Pubitemid 23275809)
21. Holtzman DM, Bales KR, Tenkova T, Fagan AM, Parsadanian M, Sartorius LJ, Mackey B, Olney J, McKeel D, Wozniak D, Paul SM: Apolopoprotein E isoform-dependent amyloid deposition and neuritic degeneration in a mouse model of Alzheimer's disease. Proc Natl Acad Sci USA 2002; 97: 2892-2897.
22. Fagan AM, Watson M, Parsadanian M, Bales KR, Paul SM, Holtzman DM: Human and murine APOE markedly alters A beta metabolism before and after plaque formation in a mouse model of Alzheimer's disease. Neurobiol Dis 2002; 9: 305-318. (Pubitemid 34442079)
23. Sunderland T, Mirza N, Putnam KT, Linker G., Bhupali D, Durham R, Soares H, Kimmel L, Friedman D, Bergeson J: Cerebrospinal fluid beta-amyloid 1-42 and tau in control subjects at risk for Alzheimer's disease: the effect of APOE epsilon4 allele. Biol. Psychiatry 2004; 56: 670-676. (Pubitemid 39446849)
24. Tiraboschi P, Hansen LA, Masliah E, Alford M, Thal LJ, Corey-Bloom J: Impact of APOE genotype on neuropathologic and neurochemical markers of Alzheimer disease. Neurology 2004; 62: 1977-1983. (Pubitemid 38738207)
25. Braak H, Braak E: Neuropathological staging of Alzheimer-related changes. Acta Neuropathol 1991; 82: 239-259.