Improvement of the lipid profile in post menopausal women who use estradiol and testosterone implants

Gynecological Endocrinology

Volumn 28, Issue 10, 2012, Pages 767-769

  Britto, Renata ^a   Araújo, Leila ^a   Barbosa, Ione ^a   Silva, Lidia ^a  

^a FEDERAL UNIVERSITY OF BAHIA   (Brazil)

Author keywords

Androgens; Hormone replacement therapy; Lipoprotein; Postmenopausal women; Testosterone

Indexed keywords

ESTRADIOL; GLUCOSE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LOW DENSITY LIPOPROTEIN CHOLESTEROL; TESTOSTERONE; TRIACYLGLYCEROL;

ADULT; AGED; ARTICLE; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; FEMALE; FOLLOW UP; GLUCOSE BLOOD LEVEL; HORMONAL THERAPY; HUMAN; IMPLANT; LIPID BLOOD LEVEL; MAJOR CLINICAL STUDY; MENOPAUSE; PHYSICAL ACTIVITY; POSTMENOPAUSE; PRIORITY JOURNAL; TREATMENT RESPONSE; TRIACYLGLYCEROL BLOOD LEVEL;

ADULT; AGED; ANDROGENS; BRAZIL; CARDIOVASCULAR DISEASES; COHORT STUDIES; DRUG IMPLANTS; ESTRADIOL; ESTROGEN REPLACEMENT THERAPY; FEMALE; HUMANS; HYPERLIPIDEMIAS; LIPIDS; MIDDLE AGED; POSTMENOPAUSE; PROSPECTIVE STUDIES; RISK; TESTOSTERONE; TIME FACTORS;

EID: 84866384493     PISSN: 09513590     EISSN: 14730766     Source Type: Journal    
DOI: 10.3109/09513590.2012.664191     Document Type: Article

References (30)

1. Collins P, Rosano GM, Jiang C, Lindsay D, Sarrel PM, Poole-Wilson PA. Cardiovascular protection by oestrogen - A calcium antagonist effect? Lancet 1993;341:1264-1265.
2. Jensen J. Effects of sex steroids on serum lipids and lipoproteins. Baillieres Clin Obstet Gynaecol 1991;5:867-887.
3. La VC. Sex hormones and cardiovascular risk. Hum Reprod 1992;7: 162-167.
4. Rozenberg S, Liebens I, Vandromme J, Hotimsky A, Van Rijsselberge M. Cardiovascular protection by estrogen: A hemodynamic mechanism? Int J Fertil Menopausal Stud 1994;39 Suppl 1:36-42.
5. Grodstein F, Stampfer M. The epidemiology of coronary heart disease and estrogen replacement in postmenopausal women. Prog Cardiovasc Dis 1995;38:199-210.
6. Colditz GA, Willett WC, Stampfer MJ, Rosner B, Speizer FE, Hennekens CH. Menopause and the risk of coronary heart disease in women. N Engl J Med 1987;316:1105-1110.
7. Stampfer MJ, Colditz GA, Willett WC, Manson JE, Rosner B, Speizer FE, Hennekens CH. Postmenopausal estrogen therapy and cardiovascular disease. Ten-year follow-up from the nurses' health study. N Engl J Med 1991;325:756-762.
8. Stampfer MJ, Grodstein F, Bechtel S. Postmenopausal estrogen and cardiovascular disease. Contemp Intern Med 1994;6:47-56, 59.
9. Wassertheil-Smoller S, Hendrix SL, Limacher M, Heiss G, Kooperberg C, Baird A, Kotchen T, et al.; WHI Investigators. Effect of estrogen plus progestin on stroke in postmenopausal women: The Women's Health Initiative: A randomized trial. JAMA 2003;289:2673-2684.
10. Rossouw JE, Anderson GL, Prentice RL, LaCroix AZ, Kooperberg C, Stefanick ML, Jackson RD, et al.; Writing Group for the Women's Health Initiative Investigators. Risks and benefits of estrogen plus progestin in healthy postmenopausal women: Principal results From the Women's Health Initiative randomized controlled trial. JAMA 2002;288:321-333.
11. Rossouw JE, Prentice RL, Manson JE, Wu L, Barad D, Barnabei VM, Ko M, et al. Postmenopausal hormone therapy and risk of cardiovascular disease by age and years since menopause. JAMA 2007;297:1465-1477.
12. Kurdoglu M, Yildirim M, Kurdoglu Z, Erdem A, Erdem M, Bilgihan A, Goktas B. Cardiovascular risk assessment with oxidised LDL measurement in postmenopausal women receiving intranasal estrogen replacement therapy. Gynecol Endocrinol 2011;27:551-557.
13. Yoshida T, Takahashi K, Yamatani H, Takata K, Kurachi H. Impact of surgical menopause on lipid and bone metabolism. Climacteric 2011;14:445-452.
14. de Paula FJ, Soares JM Jr, Haidar MA, de Lima GR, Baracat EC. The benefits of androgens combined with hormone replacement therapy regarding to patients with postmenopausal sexual symptoms. Maturitas 2007;56:69-77.
15. Appleby L, Montgomery J. Effect of combined implants of oestradiol and testosterone on libido in postmenopausal women. Br Med J (Clin Res Ed) 1987;294:1417-1418.
16. Montgomery JC, Appleby L, Brincat M, Versi E, Tapp A, Fenwick PB, Studd JW. Effect of oestrogen and testosterone implants on psychological disorders in the climacteric. Lancet 1987;1:297-299.
17. Panay N, Al-Azzawi F, Bouchard C, Davis SR, Eden J, Lodhi I, Rees M, et al. Testosterone treatment of HSDD in naturally menopausal women: The ADORE study. Climacteric 2010;13:121-131.
18. Filho AM, Barbosa IC, Maia H Jr, Genes CC, Coutinho EM. Effects of subdermal implants of estradiol and testosterone on the endometrium of postmenopausal women. Gynecol Endocrinol 2007;23:511-517.
19. Zang H, Carlström K, Arner P, Hirschberg AL. Effects of treatment with testosterone alone or in combination with estrogen on insulin sensitivity in postmenopausal women. Fertil Steril 2006;86:136-144.
20. Genazzani AR, Pluchino N. Androgen replacement therapy and cardiovascular function. Climacteric 2009;12 Suppl 1:102-107.
21. Noyan V, Yucel A, Sagsoz N. The association of androgenic sex steroids with serum lipid levels in postmenopausal women. Acta Obstet Gynecol Scand 2004;83:487-490.
22. Leão LM, Duarte MP, Silva DM, Bahia PR, Coeli CM, de Farias ML. Influence of methyltestosterone postmenopausal therapy on plasma lipids, inflammatory factors, glucose metabolism and visceral fat: A randomized study. Eur J Endocrinol 2006;154:131-139.
23. Mudali S, Dobs AS, Ding J, Cauley JA, Szklo M, Golden SH; atherosclerosis risk in communities study. Endogenous postmenopausal hormones and serum lipids: The atherosclerosis risk in communities study. J Clin Endocrinol Metab 2005;90:1202-1209.
24. Sherwin BB, Gelfand MM, Schucher R, Gabor J. Postmenopausal estrogen and androgen replacement and lipoprotein lipid concentrations. Am J Obstet Gynecol 1987;156:414-419.
25. Mosca L, Banka CL, Benjamin EJ, Berra K, Bushnell C, Dolor RJ, Ganiats TG, et al.; Expert Panel/Writing Group; American Academy of Physician Assistants; American Association for Clinical Chemistry; American Association of Cardiovascular and Pulmonary Rehabilitation; American College of Chest Physicians; American College of Emergency Physicians; American Diabetes Association; American Geriatrics Society; American Society for Preventive Cardiology; American Society of Echocardiography; American Society of Nuclear Cardiology; Association of Women's Health, Obstetric and Neonatal Nurses; Global Alliance for Women's Health; Mended Hearts, Inc; National Black Nurses Association; National Black Women's Health Imperative; National Women's Health Resource Center; North American Menopause Society; Partnership for Gender-Specific Medicine at Columbia University; Preventive Cardiovascular Nurses Association; Society for Vascular Medicine and Biology; Society for Women's Health Research; Society of Geriatric Cardiolog Women in Thoracic Surgery; WomenHeart: The National Coalition for Women with Heart Disease. Evidence-based guidelines for cardiovascular disease prevention in women: 2007 update. J Am Coll Cardiol 2007;49:1230-1250.
26. Rollins G. Guidelines advise against hormone replacement therapy for cardiovascular disease prevention. Rep Med Guidel Outcomes Res 2001;12:7-9.
27. Mieres JH. Review of the American Heart Association's guidelines for cardiovascular disease prevention in women. Heart 2006;92 Suppl 3:iii10-iii13.
28. Farish E, Fletcher CD, Hart DM, Azzawi FA, Abdalla HI, Gray CE. The effects of hormone implants on serum lipoproteins and steroid hormones in bilaterally oophorectomised women. Acta Endocrinol 1984;106: 116-120.
29. Watts NB, Notelovitz M, Timmons MC, Addison WA, Wiita B, Downey LJ. Comparison of oral estrogens and estrogens plus androgen on bone mineral density, menopausal symptoms, and lipid-lipoprotein profiles in surgical menopause. Obstet Gynecol 1995;85:529-537.
30. Castelo-Branco C, Vicente JJ, Figueras F, Sanjuan A, Martínez de Osaba MJ, Casals E, Pons F, et al. Comparative effects of estrogens plus androgens and tibolone on bone, lipid pattern and sexuality in postmenopausal women. Maturitas 2000;34:161-168.