The benefits of androgens combined with hormone replacement therapy regarding to patients with postmenopausal sexual symptoms

Maturitas

Volumn 56, Issue 1, 2007, Pages 69-77

  de Paula, Fernando J F ^a   Soares Jr , José M ^a   Haidar, Mauro A ^a   Lima, Geraldo Rodrigues de ^a   Baracat, Edmund C ^a  

^a NONE

Author keywords

Hormone replacement therapy; Methyltestosterone; Postmenopause; Sexual disturbance

Indexed keywords

CHOLESTEROL; CONJUGATED ESTROGEN PLUS MEDROXYPROGESTERONE ACETATE; ESTRADIOL; FOLLITROPIN; GLUCOSE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LOW DENSITY LIPOPROTEIN CHOLESTEROL; METHYLTESTOSTERONE; PLACEBO; TESTOSTERONE; TRIACYLGLYCEROL;

ADULT; AGGRESSIVENESS; ARTICLE; CARDIOVASCULAR RISK; CHOLESTEROL BLOOD LEVEL; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DOUBLE BLIND PROCEDURE; ESTRADIOL BLOOD LEVEL; FEMALE; FOLLITROPIN BLOOD LEVEL; GLUCOSE BLOOD LEVEL; HORMONE SUBSTITUTION; HUMAN; MAJOR CLINICAL STUDY; MCCOY SEX SCALE; MENOPAUSAL SYNDROME; NERVOUSNESS; RANDOMIZED CONTROLLED TRIAL; RATING SCALE; SEXUAL BEHAVIOR; SEXUAL DYSFUNCTION; SEXUAL SATISFACTION; SIDE EFFECT; TESTOSTERONE BLOOD LEVEL; TRIACYLGLYCEROL BLOOD LEVEL;

CROSS-OVER STUDIES; DOUBLE-BLIND METHOD; DRUG THERAPY, COMBINATION; ESTROGEN REPLACEMENT THERAPY; ESTROGENS; FEMALE; HUMANS; LIBIDO; MEDROXYPROGESTERONE 17-ACETATE; METHYLTESTOSTERONE; MIDDLE AGED; POSTMENOPAUSE; SEXUAL BEHAVIOR; TESTOSTERONE CONGENERS;

GREAT ISLAND VIRUS;

EID: 33845420111     PISSN: 03785122     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.maturitas.2006.06.005     Document Type: Article

References (36)

1. Burger H.G., Dudley E.C., Cui J., Dennerstein L., and Hopper J.L. A prospective longitudinal study of serum testosterone, dehydroepiandrosterone sulphate and sex hormone binding globulin levels through the menopause transition. J Clin Endocrinol Metab 85 (2000) 2832-2938
2. Slater C., Souter I., Zhang C., Guan C., Stanczyk F., and Mishell D. Pharmacokinetics of testosterone after percutaneous gel or buccal administration. Fertil Steril 1 (2001) 32-37
3. Modelska K. Female sexual dysfunction in postmenopausal women: systematic review of placebo-controlled trials. Am J Obstet Gynecol 188 (2003) 286-293
4. Palacios S., Tobar A.C., and Menendez C. Sexuality in the climacteric years. Maturitas 43 Suppl. 1 (2002) S69-S77
5. Sarrel P.M. Psychosexual effects of menopause: role of androgens. Am J Obstet Gynecol 180 (1999) S319-S324
6. Bachmann G.A., and Leiblum S.R. The impact of hormones on menopausal sexuality: a literature review. Menopause 11 (2004) 120-130
7. Sherwin B.B., Gelfand M.M., and Brender W. Androgen enhances sexual motivation in females: a prospective, crossover study of sex steroid administration in the surgical menopause. Psychosom Med 47 (1985) 339-351
8. Dennerstein L., Randolph J., Taffe J., Dudley E., and Burger H. Hormones, mood, sexuality, and the menopausal transition. Fertil Steril 77 Suppl. 4 (2002) 42-48
9. Laumann E.O., Paik A., and Raymond R.C. Sexual dysfunction in the Unites States. JAMA 10 (1999) 537-544
10. Leiblum S.R., Koochaki P.E., Rodenberg C.A., Barton I.P., and Rosen R.C. Hypoactive sexual desire disorder in postmenopausal women: US results from the Women's International Study of Health and Sexuality (WISHeS). Menopause 13 (2006) 46-56
11. Sarrel P.M., Dobay B., and Wiita B. Estrogen and estrogen androgen replacement in postmenopausal women dissatisfied with estrogen-only therapy. J Reprod Med 43 (1998) 847-856
12. Dennerstein L., Lehert P., and Dudley E. Short scale to measure female sexuality: adapted from McCoy Female Sexuality Questionnaire. J Sex Marital Ther 27 (2001) 339-351
13. McCoy N.L., and Davidson J.M. A longitudinal study of the effects of menopause on sexuality. Maturitas 7 (1985) 203-210
14. Soares C.N., Poitras J.R., and Prouty J. Effect of reproductive hormones and selective estrogen receptor modulators on mood during menopause. Drugs Aging 20 (2003) 85-100
15. Modelska K., and Cummings S. Female sexual dysfunction in postmenopausal women: systematic review of placebo-controlled trials. Am J Obstet Gynecol 188 (2003) 286-293
16. Pearce J., Hawton K., and Blake F. Psychological and sexual symptoms associated with the menopause and the effects of hormone replacement therapy. Br J Psychiatry 167 (1995) 163-173
17. Dobs A.S., Nguyen T., Pace C., and Roberts C.P. Differential effects of oral estrogen versus oral estrogen-androgen replacement therapy on body composition in postmenopausal women. J Clin Endocrinol Metab 87 (2002) 1509-1516
18. Keil K. Urogenital atrophy: diagnosis, sequelae, and management. Curr Womens Health Rep 2 (2002) 305-311
19. Kaplan H.S., and Owett T. The female androgen deficiency syndrome. J Sex Marital Ther 19 (1993) 3-24
20. Davis S.R. Androgen replacement in women: a commentary. J Clin Endocrinol Metab 84 (1999) 1888-1991
21. Davis S.R., Walker K.Z., and Strauss B.J.G. Effects of estradiol with and without testosterone on body composition and relationships with lipids in postmenopausal women. Menopause 7 (2000) 395-401
22. Barret-Connor E., Timmons M.C., Young R., Addison W.W., and Notelovitz M. Interim safety analysis of a two-year study comparing oral estrogen-androgen and conjugated estrogens in surgically menopausal women. J Womens Health 5 (1996) 593-601
23. Simon J.A. Safety of estrogen/androgen regimens. J Reprod Med 46 (2001) 281-290
24. Schreiner-Engel P., Schiavi R.C., Smith H., and White D. Sexual arousability and the menstrual cycle. Psychosom Med 43 (1981) 199-214
25. Shabsigh R., Katz M., Yan G., and Makhsida N. Cardiovascular issues in hypogonadism and testosterone therapy. Am J Cardiol 96 December (12B) (2005) 67M-72M
26. Writing Group for the Women's Health Initiative Investigators. Risks and benefits of estrogen plus progestin in healthy postmenopausal women: principal results from the Women's Health Initiative randomized controlled trial. JAMA 288 (2002) 321-333
27. Bancroft J., Sanders D., Davidson D., and Warner P. Mood, sexuality, hormones, and the menstrual cycle. III. Sexuality and the role of androgens. Psychosom Med 45 (1983) 509-516
28. Zumoff B., Strain G.W., Miller L.K., and Rosner W. Twenty-four-hour mean plasma testosterone concentration declines with age in normal remenopausal women. J Clin Endocrinol Metab 80 (1995) 1429-1430
29. Redmond G.P. Hormones and sexual function. Int J Fertil Womens Med 44 (1999) 193-197
30. Hoeger K.M., and Guzick D.S. The use of androgens in menopause. Clin Obstet Gynecol 42 (1999) 883-894
31. Gelfand M.M., and Wiita B. Androgen and estrogen-androgen hormone replacement therapy: a review of the safety literature, 1941-1996. Clin Ther 19 (1997) 383-404
32. Davis S.R., McCloud P., Strauss B.J., and Burger H. Testosterone enhances estradiol's effects on postmenopausal bone density and sexuality. Maturitas 21 (1995) 227-236
33. Burger H., Hailes J., Nelson J., and Menelaus M. Effect of combined implants of oestradiol and testosterone on libido in postmenopausal women. Br Med J (Clin Res Ed) 11 294 (1987) 936-937
34. Lobo R.A., Rosen R.C., Yang H.M., Block B., and Van Der Hoop R.G. Comparative effects of oral esterified estrogens with and without methyltestosterone on endocrine profiles and dimensions of sexual function in postmenopausal women with hypoactive sexual desire. Fertil Steril 79 June (6) (2003) 1341-1352
35. Buster J.E., Kingsberg S.A., Aguirre O., et al. Testosterone patch for low sexual desire in surgically menopausal women: a randomized trial. Obstet Gynecol 105 May (5 Pt. 1) (2005) 944-952
36. Simon J., Braunstein G., Nachtigall L., et al. Testosterone patch increases sexual activity and desire in surgically menopausal women with hypoactive sexual desire disorder. J Clin Endocrinol Metab 90 September (9) (2005) 5226-5233