Synthesis of a chiral alcohol using a rationally designed Saccharomyces cerevisiae reductase and a NADH cofactor regeneration system

Journal of Molecular Catalysis B: Enzymatic

Volumn 84, Issue , 2012, Pages 15-21

  Jung, Jihye ^a   Park, Seongsoon ^b   Kim, Hyung Kwoun ^a  

^a The Catholic University of Korea   (South Korea)

^b Sungshin Women's University   (South Korea)

Author keywords

Chiral compound; Cofactor preference; NADH; Protein engineering; Reductase

Indexed keywords

CHIRAL COMPOUNDS; COFACTORS; NADH; PROTEIN ENGINEERING; REDUCTASE;

AMINO ACIDS; GENETIC ENGINEERING; HYDROGEN BONDS;

YEAST;

ADENOSINE; AMINO ACID; BUTYRIC ACID ETHYL ESTER; ETHYL 4 CHLORO 3 OXOBUTANOATE; FORMATE DEHYDROGENASE; GLUCOSE DEHYDROGENASE; HYDROXYL GROUP; MUTANT PROTEIN; OXIDOREDUCTASE; PHOSPHATE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE COFACTOR; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; RIBOSE; SACCHAROMYCES CEREVISIAE PROTEIN; UNCLASSIFIED DRUG;

ALCOHOL PRODUCTION; CHEMICAL INTERACTION; CHIRALITY; COMPUTER MODEL; CONFERENCE PAPER; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME BINDING; ENZYME KINETICS; HYDROGEN BOND; MOLECULAR DOCKING; MOLECULAR MODEL; NONHUMAN; REACTION TIME; SITE DIRECTED MUTAGENESIS; STRUCTURAL HOMOLOGY; SYNTHESIS; WILD TYPE;

SACCHAROMYCES CEREVISIAE;

EID: 84866381907     PISSN: 13811177     EISSN: 18733158     Source Type: Journal    
DOI: 10.1016/j.molcatb.2012.01.016     Document Type: Conference Paper

References (23)

1. K. Goldberg, K. Schroer, S. Ltz, and A. Liese Appl. Microbiol. Biotechnol. 76 2007 237 248
2. J.C. Moore, D.J. Pollard, B. Kosjek, and P.N. Devine Acc. Chem. Res. 40 2007 1412 1419
3. A. Weckbecker, H. Gröger, and W. Hummel Adv. Biochem. Eng. Biotechnol. 120 2010 195 242
4. Y.H. Choi, H.J. Choi, D. Kim, K.N. Uhm, and H.K. Kim Appl. Microbiol. Biotechnol. 87 2010 185 193
5. H.J. Park, J. Jung, H.J. Choi, K.N. Uhm, and H.K. Kim J. Microbiol. Biotechnol. 20 2010 1300 1306
6. Q. Ye, P. Ouyang, and H. Ying Appl. Microbiol. Biotechnol. 89 2011 513 522
7. M. Bozic, S. Pricelius, G.M. Guebitz, and V. Kokol Appl. Microbiol. Biotechnol. 85 2010 563 571
8. R. Kratzer, M. Pukl, S. Egger, M. Vogl, L. Brecker, and B. Nidetzky Biotechnol. Bioeng. 108 2010 797 803
9. K. Schroer, U. Mackfeld, I.A.W. Tan, C. Wandrey, F. Heuser, S. Bringer-Meyer, A. Weckbecker, W. Hummel, T. Daussmann, R. Pfaller, A. Liese, and S. Ltz J. Biotechnol. 132 2007 438 444
10. V.Z. Pletnev, C.M. Weeks, and W.L. Duax Proteins 57 2004 294 301
11. S. Banta, B.A. Swanson, S. Wu, A. Jarnagin, and S. Anderson Protein Eng. 15 2002 131 140
12. M. Katzberg, N. Skorupa-Parachin, M.F. Gorwa-Grauslund, and M. Bertau Int. J. Mol. Sci. 11 2010 1735 1758
13. G.A. Khoury, H. Fazelinia, J.W. Chin, R.J. Pantazes, P.C. Cirino, and C.D. Maranas Protein Sci. 18 2009 2125 2138
14. S. Watanabe, A. Abu Saleh, S.P. Pack, N. Annaluru, T. Kodaki, and K. Makino Microbiology 153 2007 3044 3054
15. R. Zhang, Y. Xu, Y. Sun, W. Zhang, and R. Xiao Appl. Environ. Microbiol. 75 2009 2176 2183
16. S. Banta, and S. Anderson J. Mol. Evol. 55 2002 623 631
17. M. Wada, H. Kawabata, A. Yoshizumi, M. Kataoka, S. Nakamori, Y. Yasohara, N. Kizaki, J. Hasegawa, and S. Shimizu J. Biosci. Bioeng. 87 1999 144 148
18. N. Kizaki, Y. Yasohara, J. Hasegawa, M. Wada, M. Kataoka, and S. Shimizu Appl. Microbiol. Biotechnol. 55 2001 590 595
19. J. Jung, H.J. Park, K.N. Uhm, D. Kim, and H.K. Kim Biochim. Biophys. Acta 1804 2010 1841 1849
20. L. Di Costanzo, J.E. Drury, T.M. Penning, and D.W. Christianson J. Biol. Chem. 283 2008 16830 16839
21. J. Wang, P. Cieplak, and P.A. Kollman J. Comput. Chem. 21 2000 1049 1074
22. J. Wang, W. Wang, P.A. Kollman, and D.A. Case J. Mol. Graph. Model. 25 2006 247 260
23. J.L. Sudmeier, E.M. Bradshaw, K.E. Haddad, R.M. Day, C.J. Thalhauser, P.A. Bullock, and W.W. Bachovchin J. Am. Chem. Soc. 125 2003 8430 8431