Caveosomal oxidative stress causes Src-p21ras activation and lysine 63 TRAF6 protein polyubiquitination in iron-induced M1 hepatic macrophage activation

Journal of Biological Chemistry

Volumn 287, Issue 38, 2012, Pages 32078-32084

  Zhong, Shuping ^a   Xu, Jun ^a,b   Li, Peggy ^a   Tsukamoto, Hidekazu ^a,b,c  

^a UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^b UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^c VA GREATER LOS ANGELES HEALTHCARE SYSTEM   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DOMINANT NEGATIVE; ENDOSOMES; FERROUS IRON; MACROPHAGE ACTIVATION; PHOSPHATIDYLINOSITOL 3-KINASE; POLYUBIQUITINATION; PROINFLAMMATORY; PROTEIN-TYROSINE PHOSPHATASE; SUPEROXIDE ANIONS; SUPEROXIDE DISMUTASES; TRANSFORMING GROWTH FACTORS; UBIQUITIN;

AMINO ACIDS; ENZYMES; MACROPHAGES; OXYGEN;

IRON;

FERROUS ION; LYSINE; PROTEIN P21; PROTEIN TYROSINE KINASE; PROTEIN TYROSINE PHOSPHATASE; SUPEROXIDE; TRANSFORMING GROWTH FACTOR BETA ACTIVATED KINASE 1; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED FACTOR 6;

ANIMAL CELL; ARTICLE; CAVEOSOME; CELL ORGANELLE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME INHIBITION; HEPATIC MACROPHAGE; INFLAMMATION; MACROPHAGE; MACROPHAGE ACTIVATION; MALE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; RAT; UBIQUITINATION;

ANIMALS; ANIONS; ENZYME ACTIVATION; IRON; LIVER; LYSINE; MACROPHAGES; MALE; MODELS, BIOLOGICAL; ONCOGENE PROTEIN P21(RAS); OXIDATIVE STRESS; POLYUBIQUITIN; PROTEIN TYROSINE PHOSPHATASES; RATS; RATS, WISTAR; SIGNAL TRANSDUCTION; SRC-FAMILY KINASES; SUPEROXIDES; TNF RECEPTOR-ASSOCIATED FACTOR 6; UBIQUITIN;

RATTUS;

EID: 84866375659     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.377358     Document Type: Article

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