Safety and tolerability of a body wash and moisturizer when applied to infants and toddlers with a history of atopic dermatitis: Results from an open-label study

Pediatric Dermatology

Volumn 29, Issue 5, 2012, Pages 590-597

  Simpson, Eric ^a   Trookman, Nathan S ^b   Rizer, Ronald L ^c   Preston, Norman ^d   Colõn, Luz E ^d   Johnson, Lori A ^d   Gottschalk, Ronald W ^d  

^a OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^b Penrose Hospital   (United States)

^c Thomas J Stephens and Associates Inc   (United States)

^d Galderma Laboratories LP   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BODY WASH; CORTICOSTEROID; DERMATOLOGICAL AGENT; SKIN MOISTURIZER; UNCLASSIFIED DRUG;

ARTICLE; ATOPIC DERMATITIS; CHILD; CORNEOMETRY; CORTICOSTEROID THERAPY; DRUG SAFETY; DRUG TOLERABILITY; DRY SKIN; ERYTHEMA; FEMALE; HUMAN; HYDRATION; INFANT; MAJOR CLINICAL STUDY; MALE; MEASUREMENT; MEDICAL HISTORY; MOISTURE; PRESCHOOL CHILD; PRIORITY JOURNAL; RASH; SKIN CARE; SKIN DISCOMFORT; SKIN EDEMA; SKIN WATER LOSS; STRATUM CORNEUM; TREATMENT DURATION;

CHILD, PRESCHOOL; DERMATITIS, ATOPIC; DERMATOLOGIC AGENTS; EDEMA; ERYTHEMA; EXANTHEMA; FEMALE; HUMANS; INFANT; MALE; SKIN CARE; SKIN CREAM; SOAPS; TREATMENT OUTCOME; WATER LOSS, INSENSIBLE;

EID: 84866370891     PISSN: 07368046     EISSN: 15251470     Source Type: Journal    
DOI: 10.1111/j.1525-1470.2012.01809.x     Document Type: Article

References (24)

1. Shaw TE, Currie GP, Koudelka CW, et al., Eczema prevalence in the United States: data from the 2003 National Survey of Children's Health. J Invest Dermatol 2011; 131: 67-73.
2. Williams HC, Wutherrich B,. The natural history of atopic dermatitis. In:, Williams HC, ed. Atopic dermatitis. Cambridge: Cambridge University Press, 2000: 41-59.
3. Kay J, Gawkrodger DJ, Mortimer MJ, et al., The prevalence of childhood atopic eczema in a general population. J Am Acad Dermatol 1994; 30: 35-39.
4. Rajka G,. Essential aspects of atopic dermatitis. Berlin, Germany: Springer, 1989.
5. Lewis-Jones S,. Quality of life and childhood atopic dermatitis: the misery of living with childhood eczema. Int J Clin Pract 2006; 60: 984-992.
6. Lapidus CS, Schwarz DF, Honig PJ,. Atopic dermatitis in children: who cares? who pays? J Am Acad Dermatol 1993; 28: 699-703.
7. Eichenfield LF, Hanifin JM, Luger TA, et al., Consensus conference on pediatric dermatitis. J Am Acad Dermatol 2003; 349: 1088-1095.
8. Simpson EL,. Atopic dermatitis: a review of topical treatment options. Curr Med Res Opin 2010; 26: 633-640.
9. National Collaborating Centre for Women's and Children's Health. Atopic eczema in children. Management of atopic eczema in children from birth up to the age of 12 years. London, UK: RCOG Press at the Royal College of Obstetricians and Gynaecologists, 2007.
10. Pascher F,. Systemic reactions to topically applied drugs. Bull NY Acad Med 1973; 49: 613-627.
11. Mancini AJ,. Skin. Pediatrics 2004; 113: 1114-1119.
12. Elias PM, Schmuth M,. Abnormal skin barrier in the etiopathogenesis of atopic dermatitis. Curr Opin Allergy Clin Immunol 2009; 9: 437-446.
13. Simpson E, Dutronc Y,. A new body moisturizer increases skin hydration and improves atopic dermatitis symptoms among children and adults. J Drugs Dermatol 2011; 10: 744-749.
14. Barel AO, Clarys P,. Study of the stratum corneum barrier function by transepidermal water loss measurements: comparison between two commercial instruments: evaporimeter and Tewameter. Skin Pharmacol 1995; 8: 186-195.
15. Sugarman HL, Fluhr JW, Fowler AJ, et al., The objective severity assessment of atopic dermatitis score. Arch Dermatol 2003; 139: 1417-1422.
16. Chamlin SL, Kao J, Frieden IJ, et al., Ceramide-dominant barrier repair lipids alleviate childhood atopic dermatitis: changes in barrier function provide a sensitive indicator of disease activity. J Am Acad Dermatol 2002; 47: 198-208.
17. Seidenari S, Giusti G,. Objective assessment of the skin of children affected by atopic dermatitis: a study of pH, capacitance and TEWL in eczematous and clinically uninvolved skin. Acta Derm Venereol 1995; 75: 429-433.
18. Watanabe M, Tagami H, Horii I, et al., Functional analyses of the superficial stratum corneum in atopic xerosis. Arch Dermatol 1991; 127: 1689-1692.
19. Tanaka M, Okada M, Zhen YX, et al., Decreased hydration state of the stratum corneum and reduced amino acid content of the skin surface in patients with seasonal allergic rhinitis. Br J Dermatol 1998; 139: 618-621.
20. Horii I, Nakayama Y, Obata M, et al., Stratum corneum hydration and amino acid content in xerotic skin. Br J Dermatol 1989; 121: 587-592.
21. Di Nardo A, Wertz P, Giannetti A, et al., Ceramide and cholesterol composition of the skin of patients with atopic dermatitis. Acta Derm Venereol 1998; 78: 27-30.
22. Imokawa G, Abe A, Jin K, et al., Decreased level of ceramides in stratum corneum of atopic dermatitis: an etiologic factor in atopic dry skin? J Invest Dermatol 1991; 96: 523-526.
23. Yamamoto A, Serizawa S, Ito M, et al., Stratum corneum lipid abnormalities in atopic dermatitis. Arch Dermatol Res 1991; 283: 219-223.
24. Rogiers V,. EEMCO guidance for the assessment of transepidermal water loss in cosmetic sciences. Skin Pharmacol Appl Skin Physiol 2001; 14: 117-128.