Determination of simvastatin and ezatimibe in combined tablet dosage forms by constant center spectrophotometric method

International Journal of Pharmacy and Pharmaceutical Sciences

Volumn 4, Issue SUPPL. 4, 2012, Pages 673-679

  Lotfy, Hayam Mahmoud ^a  

^a CAIRO UNIVERSITY   (Egypt)

Author keywords

Amplitude difference; Constant calculation; Constant center; Constant multiplication; Ezetimibe; Ratio difference; Simvastatin

Indexed keywords

EZETIMIBE; SIMVASTATIN;

ARTICLE; DRUG DETERMINATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; SPECTROPHOTOMETRY; TABLET FORMULATION;

EID: 84866335873     PISSN: None     EISSN: 09751491     Source Type: Journal    
DOI: None     Document Type: Article

References (40)

1. Leitersdorf E. Simultaneous estimation of simvastatin and ezetimibe in pharmaceutical formulations by RP-HPLC method. Int. J. Clin Pract 2002; 56 Suppl 2: 116-119.
2. Heek M, Farley C and Compton D. Ezetimibe selectively inhibits intestinal cholesterol absorption in rodents in the presence and absence of exocrine pancreatic function. Br. J. Pharmacol. 2001; 134. 409-417.
3. Singh S, Singh B, Bahuguna R, Wadhwa L and Saxena R. Stress degradation studies on ezetimibe and development of a validated stability-indicating HPLC assay. J. Pharm. Biomed. Anal. 2006; 41 Suppl 3: 1037-1040.
4. Sistla R, Tata V, Kashyap Y, Chandrasekar D and Diwan P. Development and validation of a reversed-phase HPLC method for the determination of ezetimibe in pharmaceutical dosage forms. J. Pharm. Biomed. Anal. 2005; 39 Suppl 3-4:517-522.
5. Mauro V F. Clinical pharmacokinetics and practical applications of simvastatin. Clin. Pharmacokinet. 1993; 24: 195-202.
6. Alberts A, Chen W J, Kuron G, Hunt V, Huff J, Hoffman, C. et al. A highly potent competitive inhibitor of hydroxymethylglutaryl-coenzyme A reductase and a cholesterol-lowering agent. Proc. Natl. Acad. Sci. 1980; 77: 3957-3961.
7. Carlucci G, Mazzeo P, Biordi L and Bologna M. Simultaneous determination of simvastatin and its hydroxy acid form in human plasma by high-performance liquid chromatography with ultraviolet detection. J. Pharm. Biomed. Anal. 1992; 10 Suppl 9: 693-697.
8. Ochiai H, Uchiyama N, Imagaki K, Hata S and Kamei T, Determination of simvastatin and its active metabolite in human plasma by column-switching high-performance liquid chromatography with fluorescence detection after derivatization with 1-bromoacetylpyrene. J. Chromatogr. B.; Biomed Appl. 1997; 694 Suppl 1: 211-217.
9. Tan L, Yang L, Zhang X, Yuan Y and Ling S. Determination of simvastatin in human plasma by high performance liquid chromatography. Se Pu. 2000;18 Suppl 3: 232-234.
10. Malenovic A, Ivanovic D, Medenica M, Jancic B and Markovic S. Retention modelling in liquid chromatographic separation of simvastatin and its six impurities applying microemulsion as eluent. J. Sep. Sci. 2004; 27 Suppl 13: 1087-1092.
11. Barrett B, Huclova J, Borek-Dohalsky V, Nemec B and Jelinek I. Validated HPLC-MS/MS method for simultaneous determination of simvastatin and simvastatin hydroxy acid in human plasma. J. Pharm. Biomed. Anal. 2006; 41 Suppl 2: 517526.
12. Wang L and Asgharnejad M. Second-derivative UV spectrometric determination of simvastatin in its tablet dosage form. J. Pharm. Biomed. Anal. 2000; 21 Suppl 6: 1243-1248.
13. Coruh O and Ozkan S. Determination of the antihyperlipidemic simvastatin by various voltammetric techniques in tablets and serum samples. Pharmazie. 2006; 61 Suppl 4: 285-290
14. Ozaltin N, Ucakturk E, Ozaltin N and Ucakturk E. Simultaneous determination of ezetimibe and simvastatin in pharmaceutical formulations by dual-mode gradient LC. Chromatographia 2007; 66: 587-591.
15. Dixit P R, Barhate R C, Nagarsenker S M. Stability-indicating HPTLC method for simultaneous determination of ezetimibe and simvastatin. J. Chromatographia 2008; 67 Suppl 1-2:101-107
16. Jain N, Jain R, Swami H, Pandey S, Jain D.K. Spectrophotometric method for estimation of simvastatin and ezetimibe in bulk drug and its combined dosage form. Int J Pharmacy Pharm Sci 2009; 1 Suppl l: 170-175.
17. Kumar D, Sujan D, Viajayasree V and Senshagiriao J. Simultaneous determination of simvastatin and ezetimibe in tablets by HPLC. E-journal of chemistry 2009; 6 Suppl 2: 541-544.
18. Lotfy H M, Aboul alamein A M and Hegazy M A. Quantitative analysis of the cholesterol-lowering drugs ezetimibe and simvastatin in pure powder, binary mixtures, and a combined dosage form by spectrophotometry, chemometry, and high-performance column liquid chromatography.J. of AOAC Inter. 2010; 39 Suppl 5:1844-1855.
19. Ashfaq M, Khana I, Qutab S and Razzaq S. HPLC determination of ezetimibe and simvastatin in pharmaceutical formulations. J. Chil. Chem. Soc. 2007; 52: 1220-1223.
20. Rajput S and Raj H. Indian J. of Pharm. Sci. Simultaneous spectroscopic estimation of ezetimibe and simvastatin in tablet dosage forms.2007; 69:759-762.
21. Palabiyit I, Onur F, Yardimci C and Ozaltin N. Simultaneous spectrophotometric determination of ezetimibe and simvastatin in pharmaceutical preparations using chemometric techniques J. Quimica Nova 2008;31 Suppl 5:1121-1124.
22. Shrestha B, Stephenrathinaraj B, Patel S, Verma N and Mazumder R. Simultaneous HPTLC estimation of simvastatin and ezetimibe in tablet dosage form E-Journal of Chemistry. 2010;7 Suppl 4:1206-1211.
23. Dinc E and Onur F. Application of a new spectrophotometric method for the analysis of a ternary mixture containing metamizol, paracetamol and caffeine in tablets. Anal. Chim. Acta 1998; 359: 93-106.
24. Mali S, Dhabale P, Gonjari I, Deshmukh V and Chanekar P. Simultaneous uv spectrophotometric methods for estimation of atenolol and amlodipine besylate in combined tablet dosage form. Int. J. Pharmacy Pharm. Sci. 2010; 2 Suppl 3:71-74.
25. Likhar A, Gupta K, and Wadodkar S. Spectrophotometric methods for the simultaneous estimation of paracetamol and etoricoxib in tablet dosage forms. Int. J. Pharmacy Pharm. Sci. 2010; 2 Suppl 1:156-161.
26. Vijaya V, Vrushali T, Vrushali K and Dhole S. spectrophotometric simultaneous determination of amlodipine besylate and hydrochlorothiazide in combined tablet dosage form by simultaneous equation, absorption ratio and first order derivative spectroscopy methods. Int. J. Chem. Res.2011; 2 Suppl 1: 7-11.
27. Wold S, Sjostrom M and Eriksson L. A basic tool of chemometrics. Chemom. Intel. Lab. Syst. 2001; 58:109-130.
28. Dinc E, Yucesoy C and Onur F. Simultaneous spectrophotometric determination of mefenamic acid and paracetamol in a pharmaceutical preparation using ratio spectra derivative spectrophotometry and chemometric methods.J. Pharm. Biomed. Anal. 2002; 28:1091-1100.
29. Blanco M, Gene J, Iturriaga H, Maspoch S and Riba, J. Diode-array detectors in flow-injection analysis Mixture resolution by multi-wavelength analysis. Talanta 1987; 34: 987-993.
30. Bosch-Reig F and Campins-Falco P. Standard addition method Part I. Fundamentals and application to analytical spectroscopy. Analyst 1988; 113: 1011-1016.
31. Verdu-Andres J., Bosch-Reig F and Compins-Falco P. H point standard addition technique for analyte determination of ternary mixtures. Analyst 1995; 120: 299-302.
32. Salinas F, Berzas Nevado J, Maspoch S and Riba J. A new spectrophotometric method for quantitative multicomponent analysis resolution of mixtures of salicylic and salicyluric acids Talanta 1990; 37 Suppl 3: 347-351.
33. Berzas Nevado J, Guiberteau C and Salinas F. Spectrophotometric resolution of ternary mixtures of salicylaldehyde, 3-hydroxy benzaldehyde and 4-hydroxy benzaldehyde by the derivative ratio spectrum zero crossing method Talanta, 1992; 39: 547-553.
34. Berzas Nevado J, Cabanillas C and Contento S. A. Simultaneous spectrophotometric determination of three food dyes by using the first derivative of ratio spectra. Talanta 1995; 42: 20432051.
35. Onur F, Yucesoy C, Dermis S, Katral M and Kukdil G. Simultaneous determination of pseudoephedrine sulfate, dexbrompheniramine maleate and loratadine in pharmaceutical preparations. Talanta 2000; 51: 269-279.
36. El-Gindy A, El-Zeany B, Awad T and Shabana M. Spectrophotometric determination of trifluoperazine HCl and isopropamide iodide in binary mixture using second derivative and second derivative of the ratio spectra methods. J. Pharm. Biomed. Anal. 2001; 26: 203-210.
37. Dinc E, Palabyik I M, Ustundag O, Yustsever F and Onur F. Simultaneous spectrophotometric determination of chlorphenoxamine hydrochloride and caffeine in a pharmaceutical preparation using first derivative of the ratio spectra and chemometric methods.J. Pharm. Biomed. Anal. 2002; 28: 591-600.
38. Lotfy H M. and Abdel-Monem Hagazy M. Comparative study of novel methods manipulating ratio spectra: An application on pharmaceutical ternary mixture of omeprazole, tinidazole and clarithromycin. Spectrochimica Acta 2012; 96: 259-270.
39. El-Bardicy M G, Lotfy H M, El-Sayed M A and El-Tarras M F. Smart stability indicating spectrophotometric methods for determination of binary mixtures without prior separation.J. of AOAC Inter. 2008; 91: 299-310.
40. International Conference on Harmonization (ICH), Q2B: Validation of Analytical Procedures: Methodology, 62, US FDA Federal Register, 1997