-
2
-
-
65949105079
-
High incidence of protein-truncating TP53 mutations in BRCA1-related breast cancer
-
Holstege H, Joosse SA, van Oostrom CT, Nederlof PM, de Vries A, Jonkers J. High incidence of protein-truncating TP53 mutations in BRCA1-related breast cancer. Cancer Res 2009;69:3625-33.
-
(2009)
Cancer Res
, vol.69
, pp. 3625-3633
-
-
Holstege, H.1
Joosse, S.A.2
van Oostrom, C.T.3
Nederlof, P.M.4
de Vries, A.5
Jonkers, J.6
-
3
-
-
37549020704
-
Recurrent gross mutations of the PTEN tumor suppressor gene in breast cancers with deficient DSB repair
-
Saal LH, Gruvberger-Saal SK, Persson C, Lövgren K, Jumppanen M, Staaf J, et al. Recurrent gross mutations of the PTEN tumor suppressor gene in breast cancers with deficient DSB repair. Nat Genet 2008;40:102-7.
-
(2008)
Nat Genet
, vol.40
, pp. 102-107
-
-
Saal, L.H.1
Gruvberger-Saal, S.K.2
Persson, C.3
Lövgren, K.4
Jumppanen, M.5
Staaf, J.6
-
4
-
-
0029027365
-
High allele loss rates at 17q12-q21 in breast and ovarian tumors from BRCAl-linked families
-
Cornelis RS, Neuhausen SL, Johansson O, Arason A, Kelsell D, Ponder BA, et al. High allele loss rates at 17q12-q21 in breast and ovarian tumors from BRCAl-linked families. Genes Chromosomes Cancer 1995;13:203-10.
-
(1995)
Genes Chromosomes Cancer
, vol.13
, pp. 203-210
-
-
Cornelis, R.S.1
Neuhausen, S.L.2
Johansson, O.3
Arason, A.4
Kelsell, D.5
Ponder, B.A.6
-
5
-
-
33749007676
-
Mouse models of BRCA1 and BRCA2 deficiency: Past lessons, current understanding and future prospects
-
Evers B, Jonkers J. Mouse models of BRCA1 and BRCA2 deficiency: past lessons, current understanding and future prospects. Oncogene 2006;25:5885-97.
-
(2006)
Oncogene
, vol.25
, pp. 5885-5897
-
-
Evers, B.1
Jonkers, J.2
-
6
-
-
77958488424
-
The molecular pathogenesis of hereditary ovarian carcinoma: Alterations in the tubal epithelium of women with BRCA1 and BRCA2 mutations
-
Norquist BM, Garcia RL, Allison KH, Jokinen CH, Kernochan LE, Pizzi CC, et al. The molecular pathogenesis of hereditary ovarian carcinoma: alterations in the tubal epithelium of women with BRCA1 and BRCA2 mutations. Cancer 2010;116:5261-71.
-
(2010)
Cancer
, vol.116
, pp. 5261-5271
-
-
Norquist, B.M.1
Garcia, R.L.2
Allison, K.H.3
Jokinen, C.H.4
Kernochan, L.E.5
Pizzi, C.C.6
-
7
-
-
84866322681
-
Evolutionary pathways in BRCA1-associated breast tumors
-
Martins FC, De S, Almendro V, Gönen M, Park SY, Blum JL, et al. Evolutionary pathways in BRCA1-associated breast tumors. Cancer Discov 2012;2:503-11.
-
(2012)
Cancer Discov
, vol.2
, pp. 503-511
-
-
Martins, F.C.1
De, S.2
Almendro, V.3
Gönen, M.4
Park, S.Y.5
Blum, J.L.6
-
8
-
-
80055077133
-
Mutation of a single allele of the cancer susceptibility gene BRCA1 leads to genomic instability in human breast epithelial cells
-
Konishi H, Mohseni M, Tamaki A, Garay JP, Croessmann S, Karnan S, et al. Mutation of a single allele of the cancer susceptibility gene BRCA1 leads to genomic instability in human breast epithelial cells. Proc Natl Acad Sci U S A 2011;108:17773-8.
-
(2011)
Proc Natl Acad Sci U S A
, vol.108
, pp. 17773-17778
-
-
Konishi, H.1
Mohseni, M.2
Tamaki, A.3
Garay, J.P.4
Croessmann, S.5
Karnan, S.6
-
9
-
-
68349130357
-
Aberrant luminal progenitors as the candidate target population for basal tumor development in BRCA1 mutation carriers
-
Lim E, Vaillant F, Wu D, Forrest NC, Pal B, Hart AH, et al. Aberrant luminal progenitors as the candidate target population for basal tumor development in BRCA1 mutation carriers. Nat Med 2009;15:907-13.
-
(2009)
Nat Med
, vol.15
, pp. 907-913
-
-
Lim, E.1
Vaillant, F.2
Wu, D.3
Forrest, N.C.4
Pal, B.5
Hart, A.H.6
-
10
-
-
79551614327
-
Genetic predisposition directs breast cancer phenotype by dictating progenitor cell fate
-
Proia TA, Keller PJ, Gupta PB, Klebba I, Jones AD, Sedic M, et al. Genetic predisposition directs breast cancer phenotype by dictating progenitor cell fate. Cell Stem Cell 2011;8:149-63.
-
(2011)
Cell Stem Cell
, vol.8
, pp. 149-163
-
-
Proia, T.A.1
Keller, P.J.2
Gupta, P.B.3
Klebba, I.4
Jones, A.D.5
Sedic, M.6
-
11
-
-
77956218241
-
BRCA1 basal-like breast cancers originate from luminal epithelial progenitors and not from basal stem cells
-
Molyneux G, Geyer FC, Magnay FA, McCarthy A, Kendrick H, Natrajan R, et al. BRCA1 basal-like breast cancers originate from luminal epithelial progenitors and not from basal stem cells. Cell Stem Cell 2010;7:403-17.
-
(2010)
Cell Stem Cell
, vol.7
, pp. 403-417
-
-
Molyneux, G.1
Geyer, F.C.2
Magnay, F.A.3
McCarthy, A.4
Kendrick, H.5
Natrajan, R.6
-
12
-
-
17244373777
-
Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy
-
Farmer H, McCabe N, Lord CJ, Tutt AN, Johnson DA, Richardson TB, et al. Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy. Nature 2005;434:917-21.
-
(2005)
Nature
, vol.434
, pp. 917-921
-
-
Farmer, H.1
McCabe, N.2
Lord, C.J.3
Tutt, A.N.4
Johnson, D.A.5
Richardson, T.B.6
-
13
-
-
67650471685
-
Inhibition of poly(ADP-ribose) polymerase in tumors from BRCA mutation carriers
-
Fong PC, Boss DS, Yap TA, Tutt A, Wu P, Mergui-Roelvink M, et al. Inhibition of poly(ADP-ribose) polymerase in tumors from BRCA mutation carriers. N Engl J Med 2009;361:123-34.
-
(2009)
N Engl J Med
, vol.361
, pp. 123-134
-
-
Fong, P.C.1
Boss, D.S.2
Yap, T.A.3
Tutt, A.4
Wu, P.5
Mergui-Roelvink, M.6
-
14
-
-
77955019276
-
Oral poly(ADP-ribose) polymerase inhibitor olaparib in patients with BRCA1 or BRCA2 mutations and advanced breast cancer: A proof-of-concept trial
-
Tutt A, Robson M, Garber JE, Domchek SM, Audeh MW, Weitzel JN, et al. Oral poly(ADP-ribose) polymerase inhibitor olaparib in patients with BRCA1 or BRCA2 mutations and advanced breast cancer: a proof-of-concept trial. Lancet 2010;376:235-44.
-
(2010)
Lancet
, vol.376
, pp. 235-244
-
-
Tutt, A.1
Robson, M.2
Garber, J.E.3
Domchek, S.M.4
Audeh, M.W.5
Weitzel, J.N.6
-
15
-
-
77955039099
-
Oral poly (ADP-ribose) polymerase inhibitor olaparib in patients with BRCA1 or BRCA2 mutations and recurrent ovarian cancer: A proof-of-concept trial
-
Audeh MW, Carmichael J, Penson RT, Friedlander M, Powell B, Bell-McGuinn KM, et al. Oral poly (ADP-ribose) polymerase inhibitor olaparib in patients with BRCA1 or BRCA2 mutations and recurrent ovarian cancer: a proof-of-concept trial. Lancet 2010;376:245-51.
-
(2010)
Lancet
, vol.376
, pp. 245-251
-
-
Audeh, M.W.1
Carmichael, J.2
Penson, R.T.3
Friedlander, M.4
Powell, B.5
Bell-McGuinn, K.M.6
-
16
-
-
84860214990
-
Intra-tumour heterogeneity: A looking glass for cancer
-
Marusyk A, Almendro V, Polyak K. Intra-tumour heterogeneity: a looking glass for cancer? Nat Rev Cancer 2012;12:323-34.
-
(2012)
Nat Rev Cancer
, vol.12
, pp. 323-334
-
-
Marusyk, A.1
Almendro, V.2
Polyak, K.3
-
17
-
-
80051642095
-
Secondary somatic mutations restoring BRCA1S2 predict chemotherapy resistance in hereditary ovarian carcinomas
-
Norquist B, Wurz KA, Pennil CC, Garcia R, Gross J, Sakai W, et al. Secondary somatic mutations restoring BRCA1S2 predict chemotherapy resistance in hereditary ovarian carcinomas. J Clin Oncol 2011;29:3008-15.
-
(2011)
J Clin Oncol
, vol.29
, pp. 3008-3015
-
-
Norquist, B.1
Wurz, K.A.2
Pennil, C.C.3
Garcia, R.4
Gross, J.5
Sakai, W.6
-
18
-
-
77149157867
-
Synthetic lethal targeting of PTEN mutant cells with PARP inhibitors
-
Mendes-Pereira AM, Martin SA, Brough R, McCarthy A, Taylor JR, Kim JS, et al. Synthetic lethal targeting of PTEN mutant cells with PARP inhibitors. EMBO Mol Med 2009;1:315-22.
-
(2009)
EMBO Mol Med
, vol.1
, pp. 315-322
-
-
Mendes-Pereira, A.M.1
Martin, S.A.2
Brough, R.3
McCarthy, A.4
Taylor, J.R.5
Kim, J.S.6
-
19
-
-
83455229693
-
BRCA1 RING function is essential for tumor suppression but dispensable for therapy resistance
-
Drost R, Bouwman P, Rottenberg S, Boon U, Schut E, Klarenbeek S, et al. BRCA1 RING function is essential for tumor suppression but dispensable for therapy resistance. Cancer Cell 2011;20:797-809.
-
(2011)
Cancer Cell
, vol.20
, pp. 797-809
-
-
Drost, R.1
Bouwman, P.2
Rottenberg, S.3
Boon, U.4
Schut, E.5
Klarenbeek, S.6
-
20
-
-
79953766940
-
Tumour evolution inferred by single-cell sequencing
-
Navin N, Kendall J, Troge J, Andrews P, Rodgers L, McIndoo J, et al. Tumour evolution inferred by single-cell sequencing. Nature 2011;472:90-4.
-
(2011)
Nature
, vol.472
, pp. 90-94
-
-
Navin, N.1
Kendall, J.2
Troge, J.3
Andrews, P.4
Rodgers, L.5
McIndoo, J.6
|