메뉴 건너뛰기




Volumn 2, Issue 6, 2012, Pages 554-568

Gene signatures associated with mouse postnatal hindbrain neural stem cells and medulloblastoma cancer stem cells identify novel molecular mediators and predict human medulloblastoma molecular classification

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM ION; EARLY B CELL FACTOR 2; POTASSIUM ION; PROTEIN P53; PROTEIN PATCHED; SODIUM ION; SONIC HEDGEHOG PROTEIN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR EMX2; TRANSCRIPTION FACTOR PAX3; TRANSCRIPTOME; UNCLASSIFIED DRUG;

EID: 84866335047     PISSN: 21598274     EISSN: 21598290     Source Type: Journal    
DOI: 10.1158/2159-8290.CD-11-0199     Document Type: Article
Times cited : (20)

References (38)
  • 1
    • 37749024923 scopus 로고    scopus 로고
    • Neurogenesis in the cerebellum
    • Carletti B, Rossi F. Neurogenesis in the cerebellum. Neuroscientist 2008;14:91-100.
    • (2008) Neuroscientist , vol.14 , pp. 91-100
    • Carletti, B.1    Rossi, F.2
  • 2
    • 55749108014 scopus 로고    scopus 로고
    • Pathological and molecular heterogeneity of medulloblastoma
    • Gulino A, Arcella A, Giangaspero F. Pathological and molecular heterogeneity of medulloblastoma. Curr Opin Oncol 2008;20:668-75.
    • (2008) Curr Opin Oncol , vol.20 , pp. 668-675
    • Gulino, A.1    Arcella, A.2    Giangaspero, F.3
  • 4
    • 27744521637 scopus 로고    scopus 로고
    • Cerebellumand forebrain-derived stem cells possess intrinsic regional character
    • Klein C, Butt SJ, Machold RP, Johnson JE, Fishell G. Cerebellumand forebrain-derived stem cells possess intrinsic regional character. Development 2005;132:4497-508.
    • (2005) Development , vol.132 , pp. 4497-4508
    • Klein, C.1    Butt, S.J.2    Machold, R.P.3    Johnson, J.E.4    Fishell, G.5
  • 6
    • 77950091343 scopus 로고    scopus 로고
    • Cerebellar stem cells act as medulloblastoma-initiating cells in a mouse model and a neural stem cell signature characterizes a subset of human medulloblastomas
    • Sutter R, Shakhova O, Bhagat H, Behesti H, Sutter C, Penkar S, et al. Cerebellar stem cells act as medulloblastoma-initiating cells in a mouse model and a neural stem cell signature characterizes a subset of human medulloblastomas. Oncogene 2010;29:1845-56.
    • (2010) Oncogene , vol.29 , pp. 1845-1856
    • Sutter, R.1    Shakhova, O.2    Bhagat, H.3    Behesti, H.4    Sutter, C.5    Penkar, S.6
  • 7
    • 0029860591 scopus 로고    scopus 로고
    • Multipotent CNS stem cells are present in the adult mammalian spinal cord and ventricular neuroaxis
    • Weiss S, Dunne C, Hewson J, Wohl C, Wheatley M, Peterson AC, et al. Multipotent CNS stem cells are present in the adult mammalian spinal cord and ventricular neuroaxis. J Neurosci 1996;16:7599-609.
    • (1996) J Neurosci , vol.16 , pp. 7599-7609
    • Weiss, S.1    Dunne, C.2    Hewson, J.3    Wohl, C.4    Wheatley, M.5    Peterson, A.C.6
  • 8
    • 49249138157 scopus 로고    scopus 로고
    • Comparative analysis of the frequency and distribution of stem and progenitor cells in the adult mouse brain
    • Golmohammadi MG, Blackmore DG, Large B, Azari H, Esfandiary E, Paxinos G, et al. Comparative analysis of the frequency and distribution of stem and progenitor cells in the adult mouse brain. Stem Cells 2008;26:979-87.
    • (2008) Stem Cells , vol.26 , pp. 979-987
    • Golmohammadi, M.G.1    Blackmore, D.G.2    Large, B.3    Azari, H.4    Esfandiary, E.5    Paxinos, G.6
  • 9
    • 66349110796 scopus 로고    scopus 로고
    • Multipotent CD15eecancer stem cells in patched-1-deficient mouse medulloblastoma
    • Ward RJ, Lee L, Graham K, Satkunendran T, Yoshikawa K, Ling E, et al. Multipotent CD15eecancer stem cells in patched-1-deficient mouse medulloblastoma. Cancer Res 2009;69:4682-90.
    • (2009) Cancer Res , vol.69 , pp. 4682-4690
    • Ward, R.J.1    Lee, L.2    Graham, K.3    Satkunendran, T.4    Yoshikawa, K.5    Ling, E.6
  • 10
    • 0035863498 scopus 로고    scopus 로고
    • Loss of p53 but not ARF accelerates medulloblastoma in mice heterozygous for patched
    • Wetmore C, Eberhart DE, Curran T. Loss of p53 but not ARF accelerates medulloblastoma in mice heterozygous for patched. Cancer Res 2001;61:513-6.
    • (2001) Cancer Res , vol.61 , pp. 513-516
    • Wetmore, C.1    Eberhart, D.E.2    Curran, T.3
  • 11
    • 58649111264 scopus 로고    scopus 로고
    • Identification of CD15 as a marker for tumor-propagating cells in a mouse model of medulloblastoma
    • Read TA, Fogarty MP, Markant SL, McLendon RE, Wei Z, Ellison DW, et al. Identification of CD15 as a marker for tumor-propagating cells in a mouse model of medulloblastoma. Cancer Cell 2009;15:135-47.
    • (2009) Cancer Cell , vol.15 , pp. 135-147
    • Read, T.A.1    Fogarty, M.P.2    Markant, S.L.3    McLendon, R.E.4    Wei, Z.5    Ellison, D.W.6
  • 12
    • 73149110562 scopus 로고    scopus 로고
    • Biological and molecular heterogeneity of breast cancers correlates with their cancer stem cell content
    • Pece S, Tosoni D, Confalonieri S, Mazzarol G, Vecchi M, Ronzoni S, et al. Biological and molecular heterogeneity of breast cancers correlates with their cancer stem cell content. Cell 2010;140:62-73.
    • (2010) Cell , vol.140 , pp. 62-73
    • Pece, S.1    Tosoni, D.2    Confalonieri, S.3    Mazzarol, G.4    Vecchi, M.5    Ronzoni, S.6
  • 13
    • 79955681163 scopus 로고    scopus 로고
    • The intestinal stem cell signature identifies colorectal cancer stem cells and predicts disease relapse
    • Merlos-Suarez A, Barriga FM, Jung P, Iglesias M, Céspedes MV, Rossell D, et al. The intestinal stem cell signature identifies colorectal cancer stem cells and predicts disease relapse. Cell Stem Cell 2011;8:511-24.
    • (2011) Cell Stem Cell , vol.8 , pp. 511-524
    • Merlos-Suarez, A.1    Barriga, F.M.2    Jung, P.3    Iglesias, M.4    Céspedes, M.V.5    Rossell, D.6
  • 14
    • 0036455850 scopus 로고    scopus 로고
    • In vivo infusions of exogenous growth factors into the fourth ventricle of the adult mouse brain increase the proliferation of neural progenitors around the fourth ventricle and the central canal of the spinal cord
    • Martens DJ, Seaberg RM, van der Kooy D. In vivo infusions of exogenous growth factors into the fourth ventricle of the adult mouse brain increase the proliferation of neural progenitors around the fourth ventricle and the central canal of the spinal cord. Eur J Neurosci 2002;16:1045-57.
    • (2002) Eur J Neurosci , vol.16 , pp. 1045-1057
    • Martens, D.J.1    Seaberg, R.M.2    van der Kooy, D.3
  • 15
    • 77956515301 scopus 로고    scopus 로고
    • Co-graft of allogeneic immune regulatory neural stem cells (NPC) and pancreatic islets mediates tolerance, while inducing NPCderived tumors in mice
    • Melzi R, Antonioli B, Mercalli A, Battaglia M, Valle A, Pluchino S, et al. Co-graft of allogeneic immune regulatory neural stem cells (NPC) and pancreatic islets mediates tolerance, while inducing NPCderived tumors in mice. PLoS One 2010;5:e10357.
    • (2010) PLoS One , vol.5
    • Melzi, R.1    Antonioli, B.2    Mercalli, A.3    Battaglia, M.4    Valle, A.5    Pluchino, S.6
  • 17
    • 65749106405 scopus 로고    scopus 로고
    • Hypoxiainducible factors regulate tumorigenic capacity of glioma stem cells
    • Li Z, Bao S, Wu Q, Wang H, Eyler C, Sathornsumetee S, et al. Hypoxiainducible factors regulate tumorigenic capacity of glioma stem cells. Cancer Cell 2009;15:501-13.
    • (2009) Cancer Cell , vol.15 , pp. 501-513
    • Li, Z.1    Bao, S.2    Wu, Q.3    Wang, H.4    Eyler, C.5    Sathornsumetee, S.6
  • 18
    • 4944250781 scopus 로고    scopus 로고
    • Isolation and characterization of tumorigenic, stem-like neural precursors from human glioblastoma
    • Galli R, Binda E, Orfanelli U, Cipelletti B, Gritti A, De Vitis S, et al. Isolation and characterization of tumorigenic, stem-like neural precursors from human glioblastoma. Cancer Res 2004;64:7011-21.
    • (2004) Cancer Res , vol.64 , pp. 7011-7021
    • Galli, R.1    Binda, E.2    Orfanelli, U.3    Cipelletti, B.4    Gritti, A.5    de Vitis, S.6
  • 19
    • 77957326036 scopus 로고    scopus 로고
    • Early B cell factor 2 regulates hematopoietic stem cell homeostasis in a cell-nonautonomous manner
    • Kieslinger M, Hiechinger S, Dobreva G, Consalez GG, Grosschedl R. Early B cell factor 2 regulates hematopoietic stem cell homeostasis in a cell-nonautonomous manner. Cell Stem Cell 2010;7:496-507.
    • (2010) Cell Stem Cell , vol.7 , pp. 496-507
    • Kieslinger, M.1    Hiechinger, S.2    Dobreva, G.3    Consalez, G.G.4    Grosschedl, R.5
  • 20
    • 79952249809 scopus 로고    scopus 로고
    • Development and cancer of the cerebellum
    • Hatten ME, Roussel MF. Development and cancer of the cerebellum. Trends Neurosci 2011;34:134-42.
    • (2011) Trends Neurosci , vol.34 , pp. 134-142
    • Hatten, M.E.1    Roussel, M.F.2
  • 21
    • 33751080737 scopus 로고    scopus 로고
    • Different types of cerebellar GABAergic interneurons originate from a common pool of multipotent progenitor cells
    • Leto K, Carletti B, Williams IM, Magrassi L, Rossi F. Different types of cerebellar GABAergic interneurons originate from a common pool of multipotent progenitor cells. J Neurosci 2006;26:11682-94.
    • (2006) J Neurosci , vol.26 , pp. 11682-11694
    • Leto, K.1    Carletti, B.2    Williams, I.M.3    Magrassi, L.4    Rossi, F.5
  • 22
    • 0034927062 scopus 로고    scopus 로고
    • The developmental biology of brain tumors
    • Wechsler-Reya R, Scott MP. The developmental biology of brain tumors. Ann Rev Neurosci 2001;24:385-428.
    • (2001) Ann Rev Neurosci , vol.24 , pp. 385-428
    • Wechsler-Reya, R.1    Scott, M.P.2
  • 23
    • 0036336528 scopus 로고    scopus 로고
    • Neural stem cell lineages are regionally specified, but not committed, within distinct compartments of the developing brain
    • Hitoshi S, Tropepe V, Ekker M, van der Kooy D. Neural stem cell lineages are regionally specified, but not committed, within distinct compartments of the developing brain. Development 2002;129:233-44.
    • (2002) Development , vol.129 , pp. 233-244
    • Hitoshi, S.1    Tropepe, V.2    Ekker, M.3    van der Kooy, D.4
  • 24
    • 52449119078 scopus 로고    scopus 로고
    • Integrated genomics identifies five medulloblastoma subtypes with distinct genetic profiles, pathway signatures and clinicopathological features
    • Kool M, Koster J, Bunt J, Hasselt NE, Lakeman A, van Sluis P, et al. Integrated genomics identifies five medulloblastoma subtypes with distinct genetic profiles, pathway signatures and clinicopathological features. PLoS One 2008;3:e3088.
    • (2008) PLoS One , vol.3
    • Kool, M.1    Koster, J.2    Bunt, J.3    Hasselt, N.E.4    Lakeman, A.5    van Sluis, P.6
  • 25
    • 33646231995 scopus 로고    scopus 로고
    • Shh pathway activity is down-regulated in cultured medulloblastoma cells: Implications for preclinical studies
    • Sasai K, Romer JT, Lee Y, Finkelstein D, Fuller C, McKinnon PJ, et al. Shh pathway activity is down-regulated in cultured medulloblastoma cells: implications for preclinical studies. Cancer Res 2006;66:4215-22.
    • (2006) Cancer Res , vol.66 , pp. 4215-4222
    • Sasai, K.1    Romer, J.T.2    Lee, Y.3    Finkelstein, D.4    Fuller, C.5    McKinnon, P.J.6
  • 28
    • 77955362243 scopus 로고    scopus 로고
    • Hedgehog controls neural stem cells through p53-independent regulation of Nanog
    • Po A, Ferretti E, Miele E, De Smaele E, Paganelli A, Canettieri G, et al. Hedgehog controls neural stem cells through p53-independent regulation of Nanog. EMBO J 2010;29:2646-58.
    • (2010) EMBO J , vol.29 , pp. 2646-2658
    • Po, A.1    Ferretti, E.2    Miele, E.3    de Smaele, E.4    Paganelli, A.5    Canettieri, G.6
  • 29
    • 77955428416 scopus 로고    scopus 로고
    • NANOG regulates glioma stem cells and is essential in vivo acting in a cross-functional network with GLI1 and p53
    • Zbinden M, Duquet A, Lorente-Trigos A, Ngwabyt SN, Borges I, Ruiz i Altaba A. NANOG regulates glioma stem cells and is essential in vivo acting in a cross-functional network with GLI1 and p53. EMBO J 2010;29:2659-74.
    • (2010) EMBO J , vol.29 , pp. 2659-2674
    • Zbinden, M.1    Duquet, A.2    Lorente-Trigos, A.3    Ngwabyt, S.N.4    Borges, I.5    Ruiz i Altaba, A.6
  • 30
    • 18244382560 scopus 로고    scopus 로고
    • Neural stem cells and neurospheres-re-evaluating the relationship
    • Reynolds BA, Rietze RL. Neural stem cells and neurospheres-re-evaluating the relationship. Nat Methods 2005;2:333-6.
    • (2005) Nat Methods , vol.2 , pp. 333-336
    • Reynolds, B.A.1    Rietze, R.L.2
  • 32
    • 48449105147 scopus 로고    scopus 로고
    • Acquisition of granule neuron precursor identity is a critical determinant of progenitor cell competence to form Shh-induced medulloblastoma
    • Schuller U, Heine VM, Mao J, Kho AT, Dillon AK, Han YG, et al. Acquisition of granule neuron precursor identity is a critical determinant of progenitor cell competence to form Shh-induced medulloblastoma. Cancer Cell 2008;14:123-34.
    • (2008) Cancer Cell , vol.14 , pp. 123-134
    • Schuller, U.1    Heine, V.M.2    Mao, J.3    Kho, A.T.4    Dillon, A.K.5    Han, Y.G.6
  • 33
    • 48449101742 scopus 로고    scopus 로고
    • Medulloblastoma can be initiated by deletion of Patched in lineage-restricted progenitors or stem cells
    • Yang ZJ, Ellis T, Markant SL, Read TA, Kessler JD, Bourboulas M, et al. Medulloblastoma can be initiated by deletion of Patched in lineage-restricted progenitors or stem cells. Cancer Cell 2008;14:135-45.
    • (2008) Cancer Cell , vol.14 , pp. 135-145
    • Yang, Z.J.1    Ellis, T.2    Markant, S.L.3    Read, T.A.4    Kessler, J.D.5    Bourboulas, M.6
  • 34
    • 0030866154 scopus 로고    scopus 로고
    • Altered neural cell fates and medulloblastoma in mouse patched mutants
    • Goodrich LV, Milenkovic L, Higgins KM, Scott MP. Altered neural cell fates and medulloblastoma in mouse patched mutants. Science 1997;277:1109-13.
    • (1997) Science , vol.277 , pp. 1109-1113
    • Goodrich, L.V.1    Milenkovic, L.2    Higgins, K.M.3    Scott, M.P.4
  • 35
    • 79951934386 scopus 로고    scopus 로고
    • TP53 mutation is frequently associated with CTNNB1 mutation or MYCN amplification and is compatible with long-term survival in medulloblastoma
    • Pfaff E, Remke M, Sturm D, Benner A, Witt H, Milde T, et al. TP53 mutation is frequently associated with CTNNB1 mutation or MYCN amplification and is compatible with long-term survival in medulloblastoma. J Clin Oncol 2010;28:5188-96.
    • (2010) J Clin Oncol , vol.28 , pp. 5188-5196
    • Pfaff, E.1    Remke, M.2    Sturm, D.3    Benner, A.4    Witt, H.5    Milde, T.6
  • 36
    • 0030726049 scopus 로고    scopus 로고
    • Family of EbfoOlf-1-related genes potentially involved in neuronal differentiation and regional specification in the central nervous system
    • Garel S, Marin F, Mattei MG, Vesque C, Vincent A, Charnay P. Family of EbfoOlf-1-related genes potentially involved in neuronal differentiation and regional specification in the central nervous system. Dev Dyn 1997;210:191-205.
    • (1997) Dev Dyn , vol.210 , pp. 191-205
    • Garel, S.1    Marin, F.2    Mattei, M.G.3    Vesque, C.4    Vincent, A.5    Charnay, P.6
  • 37
    • 33750306143 scopus 로고    scopus 로고
    • An EBF3-mediated transcriptional program that induces cell cycle arrest and apoptosis
    • Zhao LY, Niu Y, Santiago A, Liu J, Albert SH, Robertson KD, et al. An EBF3-mediated transcriptional program that induces cell cycle arrest and apoptosis. Cancer Res 2006;66:9445-52.
    • (2006) Cancer Res , vol.66 , pp. 9445-9452
    • Zhao, L.Y.1    Niu, Y.2    Santiago, A.3    Liu, J.4    Albert, S.H.5    Robertson, K.D.6
  • 38
    • 0036333524 scopus 로고    scopus 로고
    • Emx2 regulates the proliferation of stem cells of the adult mammalian central nervous system
    • Galli R, Fiocco R, De Filippis L, Muzio L, Gritti A, Mercurio S, et al. Emx2 regulates the proliferation of stem cells of the adult mammalian central nervous system. Development 2002;129:1633-44.
    • (2002) Development , vol.129 , pp. 1633-1644
    • Galli, R.1    Fiocco, R.2    de Filippis, L.3    Muzio, L.4    Gritti, A.5    Mercurio, S.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.