The alanine aminotransferase to triglycerides ratio as a marker to identify nonalcoholic fatty liver disease

European Journal of Gastroenterology and Hepatology

Volumn 24, Issue 10, 2012, Pages 1173-1177

  Simental Mendía, Luis E ^a   Rodríguez Hernández, Heriberto ^a,b   Rodríguez Morán, Martha ^a   Guerrero Romero, Fernando ^a  

^a INSTITUTO MEXICANO DEL SEGURO SOCIAL   (Mexico)

^b UNIVERSIDAD JUÁREZ DEL ESTADO DE DURANGO   (Mexico)

Author keywords

alanine aminotransferase; nonalcoholic fatty liver disease; triglycerides

Indexed keywords

ALANINE AMINOTRANSFERASE; TRIACYLGLYCEROL;

ADULT; AGED; ALANINE AMINOTRANSFERASE BLOOD LEVEL; ARTICLE; CROSS-SECTIONAL STUDY; DIABETES MELLITUS; FEMALE; HUMAN; HYPERTENSION; MAJOR CLINICAL STUDY; MASS SCREENING; NONALCOHOLIC FATTY LIVER; OBESITY; PREDICTIVE VALUE; PRIORITY JOURNAL; RECEIVER OPERATING CHARACTERISTIC; SENSITIVITY AND SPECIFICITY; TRIACYLGLYCEROL BLOOD LEVEL; VALIDITY;

ADULT; ALANINE TRANSAMINASE; BIOLOGICAL MARKERS; CROSS-SECTIONAL STUDIES; FATTY LIVER; FEMALE; HUMANS; MIDDLE AGED; OBESITY; OVERWEIGHT; PREDICTIVE VALUE OF TESTS; ROC CURVE; SENSITIVITY AND SPECIFICITY; TRIGLYCERIDES;

EID: 84866323028     PISSN: 0954691X     EISSN: 14735687     Source Type: Journal    
DOI: 10.1097/MEG.0b013e3283564ee5     Document Type: Article

References (29)

1. Angulo P. Nonalcoholic fatty liver disease. N Engl J Med 2002; 346: 1221-1231.
2. Browning JD, Szczepaniak LS, Dobbins R, Nuremberg P, Horton JD, Cohen JC, et al. Prevalence of hepatic steatosis in an urban population in the United States: impact of ethnicity. Hepatology 2004; 40:1387-1395. (Pubitemid 39657013)
3. Clark JM, Diehl AM. Nonalcoholic fatty liver disease: an underrecognized cause of cryptogenic cirrhosis. JAMA 2003; 289:3000-3004. (Pubitemid 37430103)
4. Cairns SR, Peters TJ. Biochemical analysis of hepatic lipid in alcoholic and diabetic and control subjects. Clin Sci (Lond) 1983; 65:645-652. (Pubitemid 13018313)
5. Mulhall BP, Ong JP, Younossi ZM. Non-alcoholic fatty liver disease: an overview. J Gastroenterol Hepatol 2002; 17:1136-1143. (Pubitemid 36015607)
6. Samuel VT, Liu ZX, Qu X, Elder BD, Bilz S, Befroy D, et al. Mechanism of hepatic insulin resistance in non-alcoholic fatty liver disease. J Biol Chem 2004; 279:32345-32353. (Pubitemid 39014687)
7. Hanley AJ, Williams K, Festa A, Wagenknecht LE, D'Agostino RB Jr, Kempf J, et al. Elevations in markers of liver injury and risk of type 2 diabetes: the insulin resistance atherosclerosis study. Diabetes 2004; 53:2623-2632. (Pubitemid 39299271)
8. Defronzo RA. Dysfunctional fat cells, lipotoxicity and type 2 diabetes. Int J Clin Pract Suppl 2004; 143:9-21. (Pubitemid 39627018)
9. Unger RH. Minireview: weapons of lean body mass destruction: the role of ectopic lipids in the metabolic syndrome. Endocrinology 2003; 144:5159-5165. (Pubitemid 37476041)
10. Marchesini G, Marzocchi R, Agostini F, Bugianesi E. Nonalcoholic fatty liver disease and the metabolic syndrome. Curr Opin Lipidol 2005; 16:421-427. (Pubitemid 41017626)
11. Crespo J, Fernandez-Gil P, Hernandez-Guerra M, Cayón A, Mayorga M, Dom'inguez-Diez A, et al. Are there predictive factors of severe liver fibrosis in morbidly obese patients with non-alcoholic steatohepatitis? Obes Surg 2001; 11:254-257. (Pubitemid 32607211)
12. Dixon JB, Bhathal PS, O'Brien PE. Nonalcoholic fatty liver disease: predictors of nonalcoholic steatohepatitis and liver fibrosis in the severely obese. Gastroenterology 2001; 121:91-100. (Pubitemid 32591518)
13. Hamer OW, Aguirre DA, Casola G, Sirlin CB. Imaging features of perivascular fatty infiltration of the liver: initial observations. Radiology 2005; 237:159-169. (Pubitemid 41346160)
14. Tikkainen M, Bergholm R, Vehkavaara S, Rissanen A, Häkkinen AM, Tamminen M, et al. Effects of identical weight loss on body composition and features of insulin resistance in obese women with high and low liver fat content. Diabetes 2003; 52:701-707. (Pubitemid 36323577)
15. Yamaguchi K, Yang L, McCall S, Huang J, Yu XX, Pandey SK, et al. Inhibiting triglyceride synthesis improves hepatic steatosis but exacerbates liver damage and fibrosis in obese mice with nonalcoholic steatohepatitis. Hepatology 2007; 45:1366-1374. (Pubitemid 46918320)
16. Marceau P, Biron S, Hould FS, Marceau S, Simard S, Thung SN, et al. Liver pathology and the metabolic syndrome X in severe obesity. J Clin Endocrinol 1999; 84:1513-1517. (Pubitemid 30644245)
17. Marchesini G, Brizi M, Morselli-Labate AM, Bianchi G, Bugianesi E, McCullough AJ, et al. Association of nonalcoholic fatty liver disease with insulin resistance. Am J Med 1999; 107:450-455. (Pubitemid 29528333)
18. Ryysy L, Hakkinen AM, Goto T, Vehkavaara S, Westerbacka J, Halavaara J, et al. Hepatic fat content and insulin action on free fatty acids and glucose metabolism rather than insulin absorption are associated with insulin requirements during insulin therapy in type 2 diabetic patients. Diabetes 2000; 49:749-758. (Pubitemid 30339990)
19. Pagano G, Pacini G, Musso G, Gambino R, Mecca F, Depetris N, et al. Nonalcoholic steatohepatitis, insulin resistance, and metabolic syndrome: further evidence for an etiologic association. Hepatology 2002; 35:367-372. (Pubitemid 34106376)
20. Haynes P, Liangpunsakul S, Chalasani N. Nonalcoholic fatty liver disease in individuals with severe obesity. Clin Liver Dis 2004; 8:535-547, viii.
21. Nakao K, Nakata K, Ohtsubo N, Maeda M, Moriuchi T, Ichikawa T, et al. Association between nonalcoholic fatty liver, markers of obesity, and serum leptin level in young adults. Am J Gastroenterol 2002; 97:1796-1801. (Pubitemid 34761409)
22. Hamaguchi M, Kojima T, Itoh Y, Harano Y, Fujii K, Nakajima T, et al. The severity of ultrasonographic findings in nonalcoholic fatty liver disease reflects the metabolic syndrome and visceral fat accumulation. Am J Gastroenterol 2007; 102:2708-2715. (Pubitemid 350179336)
23. Rodriguez-Hernandez H, Cervantes-Huerta M, Gonzalez JL, Marquez-Ramirez MD, Rodriguez-Moran M, Guerrero-Romero F. Nonalcoholic fatty liver disease in asymptomatic obese women. Ann Hepatol 2010; 9:144-149.
24. Kramer MS. Clinical epidemiology and biostatistics. A primer for investigators and decision-makers. Berlin: Springer-Verlag Press; 1998. pp. 201-210.
25. Poynard T, Ratziu V, Naveau S, Thabut D, Charlotte F, Messous D, et al. The diagnostic value of biomarkers (SteatoTest) for the prediction of liver steatosis. Comp Hepatol 2005; 4:10.
26. Poynard T, Ratziu V, Charlotte F, Messous D, Munteanu M, Imbert-Bismut F, et al. Diagnostic value of biochemical markers (NashTest) for the prediction of non alcoholo steato hepatitis in patients with non-alcoholic fatty liver disease. BMC Gastroenterol 2006; 6:34.
27. Bedogni G, Bellentani S, Miglioli L, Masutti F, Passalacqua M, Castiglione A, et al. The Fatty Liver Index: a simple and accurate predictor of hepatic steatosis in the general population. BMC Gastroenterol 2006; 2:33.
28. Lin YC, Chou SC, Huang PT, Chiou HY. Risk factors and predictors of nonalcoholic fatty liver disease in Taiwan. Ann Hepatol 2011; 10:125-132.
29. Bloomgarden ZT. Second World Congress on the Insulin Resistance Syndrome: insulin resistance syndrome and nonalcoholic fatty liver disease. Diabetes Care 2005; 28:1518-1523. (Pubitemid 40756729)