Design, synthesis, and evaluation of pH-dependent hydrolyzable emetine analogues as treatment for prostate cancer

Journal of Medicinal Chemistry

Volumn 55, Issue 17, 2012, Pages 7450-7459

  Akinboye, Emmanuel S ^a   Rosen, Marc D ^b   Denmeade, Samuel R ^b   Kwabi Addo, Bernard ^c   Bakare, Oladapo ^a  

^a HOWARD UNIVERSITY   (United States)

^b JOHNS HOPKINS UNIVERSITY   (United States)

^c HOWARD UNIVERSITY CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; EMETINE; PRODRUG;

ACIDITY; ANIMAL EXPERIMENT; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; CELL STRAIN LNCAP; CONTROLLED STUDY; CULTURE MEDIUM; CYTOTOXICITY; DRUG DESIGN; DRUG SCREENING; DRUG SYNTHESIS; HUMAN; HUMAN CELL; HYDROLYSIS; IC 50; IN VITRO STUDY; MALE; MOUSE; NONHUMAN; PH; PROSTATE CANCER; STRUCTURE ACTIVITY RELATION; TUMOR MICROENVIRONMENT;

CELL LINE, TUMOR; DRUG DESIGN; EMETINE; HUMANS; HYDROGEN-ION CONCENTRATION; HYDROLYSIS; INHIBITORY CONCENTRATION 50; MALE; PROSTATIC NEOPLASMS;

EID: 84866317348     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm300426q     Document Type: Article

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