Recombinant human soluble thrombomodulin safely and effectively rescues acute promyelocytic leukemia patients from disseminated intravascular coagulation

Leukemia Research

Volumn 36, Issue 11, 2012, Pages 1398-1402

  Ikezoe, Takayuki ^a   Takeuchi, Asako ^a   Isaka, Mayuka ^a   Arakawa, Yu ^a   Iwabu, Naomi ^a   Kin, Tsukie ^a   Anabuki, Kazuki ^a   Sakai, Mizu ^a   Taniguchi, Ayuko ^a   Togitani, Kazuto ^a   Yokoyama, Akihito ^a  

^a KOCHI UNIVERSITY   (Japan)

Author keywords

Acute promyelocytic leukemia; All trans retinoic acid; Disseminated intravascular coagulation; Recombinant human soluble thrombomodulin

Indexed keywords

CYTARABINE; DEXAMETHASONE; FIBRINOGEN; FRESH FROZEN PLASMA; IDARUBICIN; LOW MOLECULAR WEIGHT HEPARIN; RECOMBINANT THROMBOMODULIN; RETINOIC ACID;

ADULT; ADULT RESPIRATORY DISTRESS SYNDROME; ARTICLE; BLOOD CLOTTING DISORDER; BRAIN HEMORRHAGE; BRAIN INFARCTION; CANCER SURVIVAL; CAUSE OF DEATH; CLINICAL ARTICLE; CONTROLLED STUDY; DISSEMINATED INTRAVASCULAR CLOTTING; DRUG EFFICACY; DRUG SAFETY; FEMALE; HUMAN; LEUKOCYTE COUNT; LEUKOCYTOSIS; MALE; MUCORMYCOSIS; OVERALL SURVIVAL; PNEUMONIA; PRIORITY JOURNAL; PROMYELOCYTIC LEUKEMIA; RETINOIC ACID SYNDROME; THROMBOCYTE COUNT;

ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; CYTARABINE; DISSEMINATED INTRAVASCULAR COAGULATION; FEMALE; HUMANS; KAPLAN-MEIER ESTIMATE; LEUKEMIA, PROMYELOCYTIC, ACUTE; MALE; MIDDLE AGED; RECOMBINANT PROTEINS; THROMBOMODULIN; TRETINOIN;

EID: 84866312450     PISSN: 01452126     EISSN: 18735835     Source Type: Journal    
DOI: 10.1016/j.leukres.2012.08.012     Document Type: Article

References (22)

1. Menell J.S., Cesarman G.M., Jacovina A.T., McLaughlin M.A., Lev E.A., Hajjar K.A. Annexin II and bleeding in acute promyelocytic leukemia. N Engl J Med 1999, 340:994-1004.
2. Ohno R., Asou N., Ohnishi K. Treatment of acute promyelocytic leukemia: strategy toward further increase of cure rate. Leukemia 2003, 17:1454-1463.
3. Jácomo R.H., Melo R.A., Souto F.R., de Mattos E.R., de Oliveira C.T., Fagundes E.M., et al. Clinical features and outcomes of 134 Brazilians with acute promyelocytic leukemia who received ATRA and anthracyclines. Haematologica 2007, 92:1431-1432.
4. Lehmann S., Ravn A., Carlsson L., Antunovic P., Deneberg S., Möllgård L., et al. Continuing high early death rate in acute promyelocytic leukemia: a population-based report from the Swedish Adult Acute Leukemia Registry. Leukemia 2011, 25:1128-1134.
5. Suzuki K., Kusumoto H., Deyashiki Y., Nishioka J., Maruyama I., Zushi M., et al. Structure and expression of human thrombomodulin, a thrombin receptor on endothelium acting as a cofactor for protein C activation. EMBO J 1987, 6:1891-1897.
6. Dittman W.A., Majerus P.W. Structure and function of thrombomodulin: a natural anticoagulant. Blood 1990, 75:329-336.
7. Dahlback B., Villoutreix B.O. The anticoagulation protein C pathway. FEBS Lett 2005, 579:3310-3316.
8. Saito H., Maruyama I., Shimazaki S., Yamamoto Y., Aikawa N., Ohno R., et al. Efficacy and safety of recombinant human soluble thrombomodulin (ART-123) in disseminated intravascular coagulation: results of a phase III, randomized, double-blind clinical trial. J Thromb Haemost 2007, 5:31-41.
9. Ikezoe T., Ikenoue N., Uchikawa N., Kojima S., Fukaya T., Yokoyama A. Use of recombinant human soluble thrombomodulin in the management of HELLP syndrome complicated by DIC. Thromb Res 2010, 126:e238-e240.
10. Sakai M., Ikezoe T., Bandobashi K., Yokoyama A. Successful treatment of thrombotic thrombocytopenic purpura associated with systemic lupus erythematosus with recombinant human soluble thrombomodulin. Thromb Res 2010, 126:e392-e393.
11. Sakai M., Ikezoe T., Bandobashi K., Togitani K., Yokoyama A. Successful treatment of transplantation-associated thrombotic microangiopathy with recombinant human soluble thrombomodulin. Bone Marrow Transplant 2010, 45:803-805.
12. Ikezoe T., Togitani K., Komatsu N., Isaka M., Yokoyama A. Successful treatment of sinusoidal obstructive syndrome after hematopoietic stem cell transplantation with recombinant human soluble thrombomodulin. Bone Marrow Transplant 2010, 45:783-785.
13. Ikezoe T., Takeuchi A., Taniguchi A., Togitani K., Yokoyama A. Recombinant human soluble thrombomodulin counteracts capillary leakage associated with engraftment syndrome. Bone Marrow Transplant 2011, 46:616-618.
14. Ikezoe T., Yang J., Nishioka C., Isaka M., Iwabu N., Sakai M., et al. Thrombomodulin enhances the antifibrinolytic and antileukemic effects of all-trans retinoic acid in acute promyelocytic leukemia cells. Exp Hematol 2012, 40:457-465.
15. Taylor F.B., Toh C.H., Hoots W.K., Wada H., Levi M. Towards definition, clinical and laboratory criteria, and a scoring system for disseminated intravascular coagulation. Thromb Haemost 2001, 86:1327-1330.
16. Yanada M., Matsushita T., Suzuki M., Kiyoi H., Yamamoto K., Kinoshita T., et al. Disseminated intravascular coagulation in acute leukemia: clinical and laboratory features at presentation. Eur J Haematol 2006, 77:282-287.
17. Ohno R., Asou N. Japan Adult Leukemia Study Group. The recent JALSG study for newly diagnosed patients with acute promyelocytic leukemia (APL). Ann Hematol 2004, 83(Suppl. 1):S77-S78.
18. Saito T., Ikezoe T., Daibata M., Takeuchi T., Ohtsuki Y., Taguchi H., et al. Disseminated mucormycosis (zygomycosis) in acute myeloid leukemia. Intern Med 2006, 45:1073-1074.
19. Dally N., Hoffman R., Haddad N., Sarig G., Rowe J.M., Brenner B. Predictive factors of bleeding and thrombosis during induction therapy in acute promyelocytic leukemia-a single center experience in 34 patients. Thromb Res 2005, 116:109-114.
20. De Stefano V., Sorà F., Rossi E., Chiusolo P., Laurenti L., Fianchi L., et al. The risk of thrombosis in patients with acute leukemia: occurrence of thrombosis at diagnosis and during treatment. J Thromb Haemost 2005, 3:1985-1992.
21. Binette T.M., Taylor F.B., Peer G., Bajzar L. Thrombin-thrombomodulin connects coagulation and fibrinolysis: more than an in vitro phenomenon. Blood 2007, 110:3168-3175.
22. Dubois C., Schlageter M.H., de Gentile A., Balitrand N., Toubert M.E., Krawice I., et al. Modulation of IL-8, IL-1 beta, and G-CSF secretion by all-trans retinoic acid in acute promyelocytic leukemia. Leukemia 1994, 8:1750-1757.