Recombinant human soluble thrombomodulin counteracts capillary leakage associated with engraftment syndrome

Bone Marrow Transplantation

Volumn 46, Issue 4, 2011, Pages 616-618

  Ikezoe, T ^a   Takeuchi, A ^a   Taniguchi, A ^a   Togitani, K ^a   Yokoyama, A ^a  

^a KOCHI UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

BUSULFAN; CYTARABINE; DAUNORUBICIN; FIBRIN; FLUDARABINE; GRANULOCYTE COLONY STIMULATING FACTOR; IDARUBICIN; MITOXANTRONE; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; PIPERACILLIN PLUS TAZOBACTAM; RECOMBINANT THROMBOMODULIN; TACROLIMUS;

AGED; ALLOGENEIC HEMATOPOIETIC STEM CELL TRANSPLANTATION; CANCER COMBINATION CHEMOTHERAPY; CASE REPORT; CLINICAL FEATURE; COMPUTER ASSISTED TOMOGRAPHY; DISSEMINATED INTRAVASCULAR CLOTTING; DRUG TREATMENT FAILURE; ENGRAFTMENT SYNDROME; FEVER; GRAFT VERSUS HOST REACTION; HUMAN; LETTER; LEUKEMIA; LUNG EDEMA; MALE; MYELODYSPLASTIC SYNDROME; NEUTROPHIL COUNT; PRIORITY JOURNAL; THORAX RADIOGRAPHY; TREATMENT DURATION; TREATMENT RESPONSE; WEIGHT GAIN; WHOLE BODY RADIATION;

AGED; CAPILLARY PERMEABILITY; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HUMANS; MALE; MYELODYSPLASTIC SYNDROMES; RECOMBINANT PROTEINS; SOLUBILITY; THROMBOMODULIN;

EID: 79953703447     PISSN: 02683369     EISSN: 14765365     Source Type: Journal    
DOI: 10.1038/bmt.2010.158     Document Type: Letter

References (7)

1. Spitzer TR. Engraftment syndrome following hematopoietic stem cell transplantation. Bone Marrow Transplant 2001; 27: 893-898. (Pubitemid 32529870)
2. Maruyama I. Recombinant thrombomodulin and activated protein C in the treatment of disseminated intravascular coagulation. Thoromb Haemost 1999; 82: 718-721.
3. Saito H, Maruyama I, Shimazaki S, Yamamoto Y, Aikawa N, Ohno R et al. Efficacy and safety of recombinant human soluble thrombomodulin (ART-123) in disseminated intravascular coagulation: results of a phase III, randomized, double-blind clinical trial. J Thromb Haemost 2007; 5: 31-41. (Pubitemid 44921064)
4. Schuepbach RA, Feistritzer C, Fernandez JA, Griffin JH, Riewald M. Protection of vascular barrier integrity by activated protein C in murine models depends on protease-activated receptor-1. Thromb Haemost 2009; 101: 724-733.
5. Serefhanoglu S, Goker H, Buyukasik Y, Turgut M, Sayinalp N, Haznedaroglu IC et al. Changes in vascular endothelial growth factor, angiopoietins, and Tie-2 levels with G-CSF stimulation in healthy donors. Ann Hematol 2009; 88: 667-671.
6. Myles T, Nishimura T, Yun TH, Nagashima M, Morser J, Patterson AJ et al. Thrombin activatable fibrinolysis inhibitor, a potential regulator of vascular inflammation. J Biol Chem 2003; 278: 51059-51067. (Pubitemid 38020340)
7. Abeyama K, Stern DM, Ito Y, Kawahara K, Yoshimoto Y, Tanaka M et al. The N-terminal domain of thrombomodulin sequesters high-mobility group-B1 protein, a novel anti-inflammatory mechanism. J Clin Invest 2005; 115: 1267-1274. (Pubitemid 40629045)