Feasibility of patient recruitment into clinical trials of experimental treatments for acute spinal cord injury

Journal of Clinical Neuroscience

Volumn 19, Issue 10, 2012, Pages 1338-1343

  Lee, Robert S ^a   Noonan, Vanessa K ^a   Batke, Juliet ^a   Ghag, Arvindera ^a   Paquette, Scott J ^a   Boyd, Michael C ^a   Fisher, Charles G ^a   Street, John ^a   Dvorak, Marcel F ^a   Kwon, Brian K ^a  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

Clinical trials; Neuroprotective; Recruitment; Spinal cord injury; Translational research

Indexed keywords

ADULT; CLINICAL TRIAL (TOPIC); COMORBIDITY; EMERGENCY HEALTH SERVICE; EXPERIMENTAL STUDY; FEASIBILITY STUDY; FEMALE; GLASGOW COMA SCALE; HUMAN; MAJOR CLINICAL STUDY; MALE; NEUROLOGIC EXAMINATION; NEUROTRAUMATOLOGY; PATIENT ASSESSMENT; PATIENT REFERRAL; PATIENT SATISFACTION; PATIENT SELECTION; PATIENT TRANSPORT; PRIORITY JOURNAL; RESUSCITATION; RETROSPECTIVE STUDY; REVIEW; SCORING SYSTEM; SPINAL CORD INJURY; TREATMENT PLANNING;

ACUTE DISEASE; CLINICAL TRIALS AS TOPIC; DATABASES, FACTUAL; FEASIBILITY STUDIES; HUMANS; PATIENT SELECTION; PROSPECTIVE STUDIES; SPINAL CORD INJURIES;

EID: 84866310654     PISSN: 09675868     EISSN: 15322653     Source Type: Journal    
DOI: 10.1016/j.jocn.2012.02.015     Document Type: Review

References (11)

1. C.H. Tator Review of treatment trials in human spinal cord injury: issues, difficulties, and recommendations Neurosurgery 59 2006 957 987
2. B.K. Kwon, C.G. Fisher, and M.F. Dvorak Strategies to promote neural repair and regeneration after spinal cord injury Spine 30 17 Suppl. 2005 S3 S13
3. B.K. Kwon, L.H. Sekhon, and M.G. Fehlings Emerging repair, regeneration, and translational research advances for spinal cord injury Spine 35 2010 S263 S270
4. B.K. Kwon, E. Okon, and J. Hillyer A systematic review of non-invasive pharmacologic neuroprotective treatments for acute spinal cord injury J Neurotrauma 28 2011 1545 1588
5. J.W. Fawcett, A. Curt, and J.D. Steeves Guidelines for the conduct of clinical trials for spinal cord injury as developed by the ICCP panel: spontaneous recovery after spinal cord injury and statistical power needed for therapeutic clinical trials Spinal Cord 45 2007 190 205
6. M.H. Tuszynski, J.D. Steeves, and J.W. Fawcett Guidelines for the conduct of clinical trials for spinal cord injury as developed by the ICCP Panel: clinical trial inclusion/exclusion criteria and ethics Spinal Cord 45 2007 222 231
7. F.H. Geisler, W.P. Coleman, and G. Grieco The Sygen multicenter acute spinal cord injury study Spine 26 24 Suppl. 2001 S87 S98
8. F.H. Geisler, W.P. Coleman, and G. Grieco Measurements and recovery patterns in a multicenter study of acute spinal cord injury Spine 26 24 Suppl. 2001 S68 S86
9. M.L. Sipski From the bench to the body: key issues associated with research aimed at a cure for SCI J Rehabil Res Dev 40 4 Suppl. 1 2003 1 7
10. A. Carnini, S. Casha, and V.W. Yong Reduction of PrP(C) in human cerebrospinal fluid after spinal cord injury Prion 4 2010 80 86
11. B.K. Kwon, E.B. Okon, and E. Tsai A grading system to evaluate objectively the strength of pre-clinical data of acute neuroprotective therapies for clinical translation in spinal cord injury J Neurotrauma 28 2011 1525 1543