Dynamic Link between Histone H3 Acetylation and an Increase in the Functional Characteristics of Human ESC/iPSC-Derived Cardiomyocytes

PLoS ONE

Volumn 7, Issue 9, 2012, Pages

  Otsuji, Tomomi G ^a,b,c   Kurose, Yuko ^a   Suemori, Hirofumi ^b   Tada, Masako ^a,d   Nakatsuji, Norio ^b,c  

^a Stem Cell and Drug Discovery Institute   (Japan)

^b KYOTO UNIVERSITY   (Japan)

^c KYOTO UNIVERSITY   (Japan)

^d TOTTORI UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

DIMETHYL SULFOXIDE; HISTONE H3; POTASSIUM CHANNEL; TRICHOSTATIN A;

ANIMAL CELL; ARTICLE; BETA ACTIN GENE; CELL ADHESION; CELL CULTURE; CELL DIFFERENTIATION; CELL FUNCTION; CELL MATURATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; EMBRYONIC STEM CELL; ERG1B GENE; GENE; GENE EXPRESSION; HEART ELECTROPHYSIOLOGY; HEART MUSCLE CELL; HISTONE ACETYLATION; IN VITRO STUDY; ION SELECTIVE ELECTRODE; KCNQ1 GENE; MITOSIS; MOUSE; MUSCLE FIBER CONTRACTION; NONHUMAN; PLURIPOTENT STEM CELL; RESIDUE ANALYSIS; RPL13A GENE; TRANSCRIPTION INITIATION; WESTERN BLOTTING;

ACETYLATION; ADULT; BLOTTING, WESTERN; CELL DIFFERENTIATION; CELL LINE; ELECTROPHYSIOLOGY; EMBRYONIC STEM CELLS; ETHER-A-GO-GO POTASSIUM CHANNELS; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; HISTONE DEACETYLASE INHIBITORS; HISTONES; HUMANS; HYDROXAMIC ACIDS; INDUCED PLURIPOTENT STEM CELLS; MYOCYTES, CARDIAC; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PIPERIDINES; PYRIDINES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TIME FACTORS;

EID: 84866310085     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0045010     Document Type: Article

References (40)

1. Thomson JA, Itskovitz-Eldor J, Shapiro SS, Waknitz MA, Swiergiel JJ, et al. (1998) Embryonic stem cell lines derived from human blastocysts. Science 282: 1145-1147.
2. Takahashi K, Tanabe K, Ohnuki M, Narita M, Ichisaka T, et al. (2007) Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell 131: 861-872.
3. Braam SR, Tertoolen L, van de Stolpe A, Meyer T, Passier R, et al. (2010) Prediction of drug-induced cardiotoxicity using human embryonic stem cell-derived cardiomyocytes. Stem Cell Res 4: 107-116.
4. Jonsson MK, Duker G, Tropp C, Andersson B, Sartipy P, et al. (2010) Quantified proarrhythmic potential of selected human embryonic stem cell-derived cardiomyocytes. Stem Cell Res 4: 189-200.
5. Dambrot C, Passier R, Atsma D, Mummery CL, (2011) Cardiomyocyte differentiation of pluripotent stem cells and their use as cardiac disease models. Biochem J 434: 25-35.
6. Rajala K, Pekkanen-Mattila M, Aalto-Setala K, (2011) Cardiac differentiation of pluripotent stem cells. Stem Cells Int 2011: 383709.
7. Yamauchi K, Sumi T, Minami I, Otsuji TG, Kawase E, et al. (2010) Cardiomyocytes develop from anterior primitive streak cells induced by beta-catenin activation and the blockage of BMP signaling in hESCs. Genes Cells 15: 1216-1227.
8. Mummery C, Ward-van Oostwaard D, Doevendans P, Spijker R, van den Brink S, et al. (2003) Differentiation of human embryonic stem cells to cardiomyocytes: role of coculture with visceral endoderm-like cells. Circulation 107: 2733-2740.
9. Snir M, Kehat I, Gepstein A, Coleman R, Itskovitz-Eldor J, et al. (2003) Assessment of the ultrastructural and proliferative properties of human embryonic stem cell-derived cardiomyocytes. Am J Physiol Heart Circ Physiol 285: H2355-2363.
10. Zhang J, Wilson GF, Soerens AG, Koonce CH, Yu J, et al. (2009) Functional cardiomyocytes derived from human induced pluripotent stem cells. Circ Res 104: e30-41.
11. Vidarsson H, Hyllner J, Sartipy P, (2010) Differentiation of human embryonic stem cells to cardiomyocytes for in vitro and in vivo applications. Stem Cell Rev 6: 108-120.
12. Jeck CD, Boyden PA, (1992) Age-related appearance of outward currents may contribute to developmental differences in ventricular repolarization. Circ Res 71: 1390-1403.
13. Obreztchikova MN, Sosunov EA, Plotnikov A, Anyukhovsky EP, Gainullin RZ, et al. (2003) Developmental changes in IKr and IKs contribute to age-related expression of dofetilide effects on repolarization and proarrhythmia. Cardiovasc Res 59: 339-350.
14. Ahuja P, Sdek P, MacLellan WR, (2007) Cardiac myocyte cell cycle control in development, disease, and regeneration. Physiol Rev 87: 521-544.
15. Sartiani L, Bettiol E, Stillitano F, Mugelli A, Cerbai E, et al. (2007) Developmental changes in cardiomyocytes differentiated from human embryonic stem cells: a molecular and electrophysiological approach. Stem Cells 25: 1136-1144.
16. Yanagi K, Takano M, Narazaki G, Uosaki H, Hoshino T, et al. (2007) Hyperpolarization-activated cyclic nucleotide-gated channels and T-type calcium channels confer automaticity of embryonic stem cell-derived cardiomyocytes. Stem Cells 25: 2712-2719.
17. Otsuji TG, Minami I, Kurose Y, Yamauchi K, Tada M, et al. (2010) Progressive maturation in contracting cardiomyocytes derived from human embryonic stem cells: Qualitative effects on electrophysiological responses to drugs. Stem Cell Res 4: 201-213.
18. Bannister AJ, Kouzarides T, (2011) Regulation of chromatin by histone modifications. Cell Res 21: 381-395.
19. Chavan AV, Somani RR, (2010) HDAC inhibitors- new generation of target specific treatment. Mini Rev Med Chem 10: 1263-1276.
20. Redfern WS, Carlsson L, Davis AS, Lynch WG, MacKenzie I, et al. (2003) Relationships between preclinical cardiac electrophysiology, clinical QT interval prolongation and torsade de pointes for a broad range of drugs: evidence for a provisional safety margin in drug development. Cardiovasc Res 58: 32-45.
21. Harrell MD, Harbi S, Hoffman JF, Zavadil J, Coetzee WA, (2007) Large-scale analysis of ion channel gene expression in the mouse heart during perinatal development. Physiol Genomics 28: 273-283.
22. Hattori F, Chen H, Yamashita H, Tohyama S, Satoh YS, et al. (2010) Nongenetic method for purifying stem cell-derived cardiomyocytes. Nat Methods 7: 61-66.
23. Passier R, Oostwaard DW, Snapper J, Kloots J, Hassink RJ, et al. (2005) Increased cardiomyocyte differentiation from human embryonic stem cells in serum-free cultures. Stem Cells 23: 772-780.
24. Bannister AJ, Schneider R, Kouzarides T, (2002) Histone methylation: dynamic or static? Cell 109: 801-806.
25. Salameh A, Wustmann A, Karl S, Blanke K, Apel D, et al. (2010) Cyclic mechanical stretch induces cardiomyocyte orientation and polarization of the gap junction protein connexin43. Circ Res 106: 1592-1602.
26. Kim YB, Yu J, Lee SY, Lee MS, Ko SG, et al. (2005) Cell adhesion status-dependent histone acetylation is regulated through intracellular contractility-related signaling activities. J Biol Chem 280: 28357-28364.
27. Cao DJ, Wang ZV, Battiprolu PK, Jiang N, Morales CR, et al. (2011) Histone deacetylase (HDAC) inhibitors attenuate cardiac hypertrophy by suppressing autophagy. Proc Natl Acad Sci U S A 108: 4123-4128.
28. Antos CL, McKinsey TA, Dreitz M, Hollingsworth LM, Zhang CL, et al. (2003) Dose-dependent blockade to cardiomyocyte hypertrophy by histone deacetylase inhibitors. J Biol Chem 278: 28930-28937.
29. Kong Y, Tannous P, Lu G, Berenji K, Rothermel BA, et al. (2006) Suppression of class I and II histone deacetylases blunts pressure-overload cardiac hypertrophy. Circulation 113: 2579-2588.
30. Hoyer K, Krenz M, Robbins J, Ingwall JS, (2007) Shifts in the myosin heavy chain isozymes in the mouse heart result in increased energy efficiency. J Mol Cell Cardiol 42: 214-221.
31. Lowes BD, Minobe W, Abraham WT, Rizeq MN, Bohlmeyer TJ, et al. (1997) Changes in gene expression in the intact human heart. Downregulation of alpha-myosin heavy chain in hypertrophied, failing ventricular myocardium. J Clin Invest 100: 2315-2324.
32. Reiser PJ, Portman MA, Ning XH, Schomisch Moravec C, (2001) Human cardiac myosin heavy chain isoforms in fetal and failing adult atria and ventricles. Am J Physiol Heart Circ Physiol 280: H1814-1820.
33. Narolska NA, Eiras S, van Loon RB, Boontje NM, Zaremba R, et al. (2005) Myosin heavy chain composition and the economy of contraction in healthy and diseased human myocardium. J Muscle Res Cell Motil 26: 39-48.
34. Hang CT, Yang J, Han P, Cheng HL, Shang C, et al. (2010) Chromatin regulation by Brg1 underlies heart muscle development and disease. Nature 466: 62-67.
35. Kawamura T, Ono K, Morimoto T, Wada H, Hirai M, et al. (2005) Acetylation of GATA-4 is involved in the differentiation of embryonic stem cells into cardiac myocytes. J Biol Chem 280: 19682-19688.
36. Hosseinkhani M, Hasegawa K, Ono K, Kawamura T, Takaya T, et al. (2007) Trichostatin A induces myocardial differentiation of monkey ES cells. Biochem Biophys Res Commun 356: 386-391.
37. Mummery CL, van Achterberg TA, van den Eijnden-van Raaij AJ, van Haaster L, Willemse A, et al. (1991) Visceral-endoderm-like cell lines induce differentiation of murine P19 embryonal carcinoma cells. Differentiation 46: 51-60.
38. Nakagawa M, Koyanagi M, Tanabe K, Takahashi K, Ichisaka T, et al. (2008) Generation of induced pluripotent stem cells without Myc from mouse and human fibroblasts. Nat. Biotechnol. 26: 101-106.
39. Yu J, Vodyanik MA, Smuga-Otto K, Antosiewicz-Bourget J, Frane JL, et al. (2007) Induced pluripotent stem cell lines derived from human somatic cells. Science 318: 1917-1920.
40. Suemori H, Yasuchika K, Hasegawa K, Fujioka T, Tsuneyoshi N, et al. (2006) Efficient establishment of human embryonic stem cell lines and long-term maintenance with stable karyotype by enzymatic bulk passage. Biochem Biophys Res Commun 345: 926-932.