Novel approach in the biosynthesis of functional carotenoids in escherichia coli

Methods in Molecular Biology

Volumn 892, Issue , 2012, Pages 133-141

  Harada, Hisashi ^a   Misawa, Norihiko ^b,c  

^a KNC Laboratories Co Ltd   (Japan)

^b KIRIN HOLDINGS CO LTD   (Japan)

^c ISHIKAWA PREFECTURAL UNIVERSITY   (Japan)

Author keywords

Astaxanthin; Lycopene; Mevalonate pathway; Pathway engineering

Indexed keywords

ACETOACETATE LITHIUM; ACETOACETIC ACID; ACETOACETIC ACID DERIVATIVE; ASTAXANTHIN; CAROTENOID; ISOPRENOID; LYCOPENE; MEVALONIC ACID; UNCLASSIFIED DRUG;

ARTICLE; BACTERIAL CELL; BIOSYNTHESIS; ESCHERICHIA COLI; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; NONHUMAN; PRIORITY JOURNAL; METABOLISM;

CAROTENOIDS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; ESCHERICHIA COLI;

EID: 84866293470     PISSN: 10643745     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-1-61779-879-5_6     Document Type: Article

References (20)

1. Britton G, Liaaen-Jensen S, Pfander H (2001) Carotenoids handbook. Birkhauser, Boston
2. Donaldon MS (2004) Nutrition and cancer: a review of the evidence for an anticancer diet. Nutr J 3:19
3. Rohmer M, Knani M, Simonin P, Sutter B, Sahm H (1993) Isoprenoid biosynthesis in bacteria: a novel pathway for early steps leading to isopentenyl diphosphate. Biochem J 295: 517-524
4. Harada H, Misawa N (2009) Novel approaches and achievements in biosynthesis of functional isoprenoids in Escherichia coli. Appl Microbiol Biotechnol 84:1021-1031
5. Misawa N (2010) Carotenoids. In: Mander L, Lui H-W (eds) Comprehensive natural products II chemistry and biology, vol 1. Elsevier, Oxford, pp 733-753
6. Kakinuma K, Dekishima Y, Matsushima Y, Eguchi T, Misawa N, Takagi M, Kuzuyama T, Seto H (2001) New approach to multiply deu-terated isoprenoids using triply engineered Escherichia coli and its potential as a tool for mechanistic enzymology. J Am Chem Soc 123: 1238-1239
7. Campos N, Rodriguez-Concepcion M, Sauret-Gueto S, Gallego F, Lois LM, Boronat A (2001) Escherichia coli engineered to synthesize isopentenyl diphosphate and dimethylallyl diphosphate from mevalonate: a novel system for the genetic analysis of the 2-C-methyl-D-erythritol 4-phosphate pathway for isoprenoid biosynthesis. Biochem J 353:59-67
8. Vadali RV, Fu Y, Bennett GN, San KY (2005) Enhanced lycopene productivity by manipulation of carbon flow to isopentenyl diphosphate in Escherichia coli. Biotechnol Prog 21: 1558-1561
9. Yoon SH, Park HM, Kim JE, Lee SH, Choi MS, Kim JY, Oh DK, Keasling JD, Kim SW (2007) Increased β-carotene production in recombi-nant Escherichia coli harboring an engineered isoprenoid precursor pathway with mevalonate addition. Biotechnol Prog 23:599-605
10. Rodriguez-Villalon A, Perez-Gil J, Rodriguez-Concepcion M (2008) Carotenoid accumulation in bacteria with enhanced supply of isoprenoid precursors by upregulation of exogenous or endogenous pathways. J Biotechnol 135:78-84
11. Harada H, Yu F, Okamoto S, Kuzuyama T, Utsumi R, Misawa N (2009) Ef ficient synthesis of functional isoprenoids from acetoacetate through metabolic pathway-engineered Escherichia coli. Appl Microbiol Biotechnol 81: 915-925
12. Yokoyama A, Miki W (1995) Composition and presumed biosynthetic pathway of carotenoids in the astaxanthin-producing bacterium Agrobacterium aurantiacum. FEMS Microbiol Lett 128:139-144
13. Fujisawa M, Harada H, Kenmoku H, Mizutani S, Misawa N (2010) Cloning and characterization of a novel gene that encodes (S)-β-bisabolene synthase from ginger, Zingiber of ficinale. Planta 232:121-130
14. Erratum, 232, 131
15. Takagi M, Kuzuyama T, Takahashi S, Seto H (2000) A gene cluster for the mevalonate pathway from Streptomyces sp. strain CL190. J Bacteriol 182:4153-4157
16. Kaneda K, Kuzuyama T, Takagi M, Hayakawa Y, Seto H (2001) An unusual isopentenyl diphosphate isomerase found in the mevalonate pathway gene cluster from Streptomyces sp. strain CL190. Proc Natl Acad Sci USA 98: 932-937
17. Misawa N, Nakagawa M, Kobayashi K, Yamano S, Izawa Y, Nakamura K, Harashima K (1990) Elucidation of the Erwinia uredovora carote-noid biosynthetic pathway by functional analysis of gene products expressed in Escherichia coli. J Bacteriol 172:6704-6712
18. Nishida Y, Adachi K, Kasai H, Shizuri Y, Shindo K, Sawabe A, Komemushi S, Miki W, Misawa N (2005) Elucidation of a carotenoid biosynthesis gene cluster encoding a novel enzyme, 2, 2'-β-hydroxylase, from Brevundimonas sp. strain SD212 and combinatorial biosynthesis of new or rare xanthophylls. Appl Environ Microbiol 71:4286-4296
19. Choi SK, Nishida Y, Matsuda S, Adachi K, Kasai H, Peng X, Komemushi S, Miki W, Misawa N (2005) Characterization of β-carotene ketolases, CrtW, from marine bacteria by complementation analysis in Escherichia coli. Mar Biotechnol (NY) 7:515-522
20. Osawa A, Harada H, Choi SK, Misawa N, Shindo K (2011) Production of caloxanthin 3'-β-D-glucoside, zeaxanthin β-D-diglucoside, and nostoxanthin in a recombinant Escherichia coli expressing system harboring seven carote-noid biosynthesis genes, including crtX and crtG. Phytochemistry 72:711-716