Variation of serum C-reactive protein (CRP) over time in pediatric cancer patients with febrile illness and its relevance to identified pathogen

Clinical Biochemistry

Volumn 45, Issue 15, 2012, Pages 1178-1182

  Sklavou, Rigina ^a   Karavanaki, Kyriaki ^b   Critselis, Eleni ^b   Kossiva, Lydia ^b   Giannaki, Maria ^a   Tsolia, Maria ^b   Papadakis, Vassilis ^a   Papargyri, Sophia ^a   Vlachou, Antonia ^a   Karantonis, Fotis ^a   Gourgiotis, Dimitris ^b   Polychronopoulou, Sophia ^a  

^a AGHIA SOPHIA CHILDREN S HOSPITAL   (Greece)

^b UNIVERSITY OF ATHENS   (Greece)

Author keywords

Children; CRP; Febrile illness; Malignancy

Indexed keywords

C REACTIVE PROTEIN;

ABNORMAL LABORATORY RESULT; ACUTE DISEASE; ANTIBODY DETECTION; ARTICLE; BACTERIAL INFECTION; CANCER PATIENT; CHILD; CHILDHOOD CANCER; CLINICAL ARTICLE; CLINICAL FEATURE; COMPARATIVE STUDY; DISEASE ASSOCIATION; FEMALE; FEVER; FOLLOW UP; HOSPITAL ADMISSION; HUMAN; LEUKOCYTE; MALE; MICROBIAL IDENTIFICATION; POLYMERASE CHAIN REACTION; PRESCHOOL CHILD; PRIORITY JOURNAL; PROSPECTIVE STUDY; PROTEIN BLOOD LEVEL; SCHOOL CHILD; VIRUS INFECTION;

ADOLESCENT; BACTERIAL INFECTIONS; BIOLOGICAL MARKERS; C-REACTIVE PROTEIN; CHILD; CHILD, PRESCHOOL; FEMALE; FEVER; HUMANS; INFANT; MALE; MYCOSES; PRECURSOR CELL LYMPHOBLASTIC LEUKEMIA-LYMPHOMA; PROSPECTIVE STUDIES; REGRESSION ANALYSIS; VIRUS DISEASES;

EID: 84866277100     PISSN: 00099120     EISSN: 18732933     Source Type: Journal    
DOI: 10.1016/j.clinbiochem.2012.07.088     Document Type: Article

References (28)

1. Wiger K., Høiby E.A., Wathne K.O. Infections in immunosuppressed children. Tidsskr Nor Laegeforen 2005, 125:1168-1172.
2. Katsibardi K., Papadakis V., Charisiadou A., Pangalis A., Polychronopoulou S. Blood stream infections through the entire course of acute lymphoblastic leukemia treatment. Neoplasma 2011, 58:326-330.
3. Miyakis S., Velegraki A., Delikou S., Parcharidou A., Papadakis V., Kitra V., et al. Invasive Acremonium strictum infection in a bone marrow transplant recipient. Pediatr Infect Dis J 2006, 25:273-275.
4. Alberth M., Majoros L., Kovalecz G., Borbás E., Szegedi I., Márton J.I. Significance of oral Candida infections in children with cancer. Pathol Oncol Res 2006, 12:237-241.
5. Bodey G.P., Rolston K.V. Management of fever in neutropenic patients. J Infect Chemother 2001, 7:1-9.
6. Katsimpardi K., Papadakis V., Pangalis A., Parcharidou A., Panagiotou J.P., Soutis M., et al. Infections in a pediatric patient cohort with acute lymphoblastic leukemia during the entire course of treatment. Support Care Cancer 2006, 14:277-284.
7. Sala A., Pencharz P., Barr R.D. Children, cancer and nutrition. A dynamic triangle in review. Cancer 2004, 100:677-687.
8. Santolaya M.E., Cofre J., Beresi V. C-reactive protein: a valuable aid for the management of febrile children with cancer and neutropenia. Clin Infect Dis 1994, 18:589-595.
9. De Bont E.S.J.M., Oude Nijhuis C., Kamps W.A., Vellenga E. Interpretation of inflammatory markers in feverish cancer patients with or without neutropenia at admission. Br J Haematol 2001, 114:485-491.
10. Laporta Baez Y., Palomero Rodriguez M.A., De Vincente Sanchez J.C., Sanabria Carretero P., Al Kassam Martinez D., Perez Ferrer A., et al. C-reactive protein in the diagnosis of postoperative infection in pediatric patients: a prospective observational study of 103 patients. J Pediatr Surg 2011, 46:1726-1731.
11. Fleischhack G., Cipic D., Kambeck I., Hasan C., Bode U. Reply to De Bont et al. Procalcitonin in paediatric cancer patients: its diagnostic relevance is superior to that of C-reactive protein, interleukin 6, interleukin 8, soluble interleukin 2 receptor and soluble tumour necrosis factor receptor II. Br J Haematol 2001, 114:485-491.
12. Erten N., Genc S., Besisik S.K., Saka B., Karan M.A., Tascioglu C. The predictive and diagnostic values of procalcitonin and C-reactive protein for clinical outcome in febrile neutropenic patients. J Chin Med Assoc 2004, 67:217-221.
13. Bayer L., Schontube M., Dorffel W. C-reactive protein, Il-6 and procalcitonin as infection parameters in children with oncologic diseases. Klin Padiatr 2000, 212:326-331.
14. Katz J.A., Mustafa M.M., Bash R.O., Cash J.V., Buchanan G.R. Value of C-reactive protein determination in the initial diagnostic evaluation of the febrile, neutropenic child with cancer. Pediatr Infect Dis J 1992, 11:708-712.
15. von Lilienfeld-Toal M., Dietrich M.P., Glasmacher A., Lehmann L., Breig P., Hahn C., et al. Markers of bacteremia in febrile neutropenic patients with hematological malignancies: procalcitonin and IL-6 are more reliable than C-reactive protein. Eur J Clin Microbiol Infect Dis Jun 22 2004, 23:539-544. Epub.
16. Kallio R., Bloigu A., Surcel H.M., Syrjala H. C-Reactive protein and erythrocyte sedimentation rate in differential diagnosis between infections and neoplastic fever in patients with solid tumours and lymphomas. Support Care Cancer 2001, 9:124-128.
17. Secmeer G., Devrim I., Kara A., Ceyhan M., Cengiz B., Kutluk T., et al. Role of procalcitonin and CRP in differentiating a stable from a deteriorating clinical course in pediatric febrile neutropenia. J Pediatr Hematol Oncol 2007, 29:107-111.
18. Dornbusch H.J., Strenger V., Kerbl R., Lackner H., Schwinger W., Sovinz P., et al. Procalcitonin and C-reactive protein do not discriminate between febrile reaction to anti-T-lymphocyte antibodies and Gram-negative sepsis. Bone Marrow Transplant 2003, 32:941-945.
19. Sasaki K., Fujita I., Hamasaki Y., Miyazaki S. Differentiating between bacterial and viral infection by measuring both C-reactive protein and 2-5-oligoadenylate synthetase as inflammatory markers. J Infect Chemother 2002, 8:76-80.
20. McNeer J.L., Kletzel M., Rademaker A., Alford K., O'Day K., Schaefer C., et al. Early elevation of C-reactive protein correlates with severe infection and nonrelapse mortality in children undergoing allogenic stem cell transplantation. Biol Blood Marrow Transplant 2010, 16:350-357.
21. Penel N., Fournier C., Clisant S., N'Guyen M. Causes of fever and value of C-reactive protein and procalcitonin in differentiating infections from paraneoplastic fever. Support Care Cancer 2004, 12:593-598.
22. Paran Y., Yablecovitch D., Choshen G., Zeitlin I., Rogowski O., Ben-Ami R., et al. C-reactive protein velocity to distinguish febrile bacterial infections from non-bacterial febrile illnesses in the emergency department. Crit Care 2009, 13:R50. 10.1186/cc7775.
23. Spasova M.I., Terzieva D.D., Tzvetkova T.Z., Stoyanova A.A., Mumdzhiev I.N., Yanev I.B., et al. Interleukin-6, interleukin-8, interleukin-10, and C-reactive protein in febrile neutropenia in children with malignant diseases. Folia Med (Plovdiv) 2005, 47:46-52.
24. El-Maghraby S.M., Moneer M.M., Ismail M.M., Shalaby L.M., El-Mahallawy H.A. The diagnostic value of C-reactive protein, interleukin-8 and monocyte chemotactic protein in risk stratification of febrile neutropenic children with hematologic malignancies. J Pediatr Hematol Oncol 2007, 29:131-136.
25. Fleischhack G., Kambeck I., Cipic D., Hasan C., Bode U. Procalcitonin in paedriatic cancer patients: its diagnostic relevance is superior to that of C-reactive protein, interleukin 6, interleukin 8, soluble interleukin 2 receptor and soluble tumor necrosis factor II. Br J Haematol 2000, 114:1093.
26. Persson L., Engervall P., Magnuson A., Vikerfors T., Soderquist B., Hansson L.O., et al. Use of inflammatory markers for early detection of bacteraemia in patients with febrile neutropenia. Scand J Infect Dis 2004, 36:365-371.
27. Kern W.V., Heiss M., Steinbach G. Prediction of gram-negative bacteremia in patients with cancer and febrile neutropenia by means of interleukin-8 levels in serum: targeting empirical monotherapy versus combination therapy. Clin Infect Dis 2001, 32:832-835.
28. Spasova M.I., Grudeva-Popova J.G., Kostyanev S.S., Genev E.D., Stoyanova A.A., Kirina V.I., et al. Risk index score for bacteremia in febrile neutropenic episodes in children with malignancies. J BUON 2009, 14:411-418.