Early Elevation of C-Reactive Protein Correlates with Severe Infection and Nonrelapse Mortality in Children Undergoing Allogeneic Stem Cell Transplantation

Biology of Blood and Marrow Transplantation

Volumn 16, Issue 3, 2010, Pages 350-357

  McNeer, Jennifer L ^a   Kletzel, Morris ^b,c   Rademaker, Alfred ^b   Alford, Kavita ^c   O'Day, Kathleen ^d   Schaefer, Colleen ^b,c   Duerst, Reggie ^b,c   Jacobsohn, David A ^b,c  

^a UNIVERSITY OF CHICAGO   (United States)

^b NORTHWESTERN UNIVERSITY   (United States)

^c CHILDREN'S MEMORIAL HOSPITAL   (United States)

^d University Medical Center at Princeton   (United States)

Author keywords

Allogeneic transplant; C reactive protein; Infection; Nonrelapse mortality; Pediatric

Indexed keywords

C REACTIVE PROTEIN;

ACUTE GRAFT VERSUS HOST DISEASE; ADOLESCENT; ADULT; ADVERSE OUTCOME; ALLOGENEIC HEMATOPOIETIC STEM CELL TRANSPLANTATION; ARTICLE; CHILD; CHILDHOOD MORTALITY; CONTROLLED STUDY; DISEASE MARKER; DISEASE SEVERITY; DONOR; FEMALE; FUNGUS; GRAM NEGATIVE BACTERIUM; GRAM POSITIVE BACTERIUM; HEMATOLOGIC DISEASE; HIGH RISK PATIENT; HUMAN; INFANT; INFECTION COMPLICATION; MAJOR CLINICAL STUDY; MALE; MORBIDITY; MYELOABLATIVE CONDITIONING; OUTCOME ASSESSMENT; PRESCHOOL CHILD; PROGNOSIS; REDUCED INTENSITY CONDITIONING; RISK FACTOR; SCHOOL CHILD; SEX DIFFERENCE; TREATMENT OUTCOME;

ADOLESCENT; ADULT; AREA UNDER CURVE; BIOLOGICAL MARKERS; C-REACTIVE PROTEIN; CHILD; CHILD, PRESCHOOL; COMMUNICABLE DISEASES; FEMALE; GRAFT VS HOST DISEASE; HEMATOLOGIC DISEASES; HEMATOLOGIC NEOPLASMS; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HUMANS; INFANT; MALE; POSTOPERATIVE COMPLICATIONS; PREDICTIVE VALUE OF TESTS; PROPORTIONAL HAZARDS MODELS; RISK FACTORS; ROC CURVE; SEX FACTORS; TRANSPLANTATION CONDITIONING; TRANSPLANTATION, HOMOLOGOUS; YOUNG ADULT;

EID: 75749113328     PISSN: 10838791     EISSN: 15236536     Source Type: Journal    
DOI: 10.1016/j.bbmt.2009.10.036     Document Type: Article

References (31)

1. Gratwohl A., Hermans J., Goldman J.M., et al. Risk assessment for patients with chronic myeloid leukaemia before allogeneic blood or marrow transplantation. Chronic Leukemia Working Party of the European Group for Blood and Marrow Transplantation. Lancet 352 (1998) 1087-1092
2. Nash R.A., Pepe M.S., Storb R., et al. Acute graft-versus-host disease: analysis of risk factors after allogeneic marrow transplantation and prophylaxis with cyclosporine and methotrexate. Blood 80 (1992) 1838-1845
3. Rocha V., Cornish J., Sievers E.L., et al. Comparison of outcomes of unrelated bone marrow and umbilical cord blood transplants in children with acute leukemia. Blood 97 (2001) 2962-2971
4. Eapen M., Zhang M.J., Devidas M., et al. Outcomes after HLA-matched sibling transplantation or chemotherapy in children with acute lymphoblastic leukemia in a second remission after an isolated central nervous system relapse: a collaborative study of the Children's Oncology Group and the Center for International Blood and Marrow Transplant Research. Leukemia 22 (2008) 281-286
5. Schlenk R.F., Pasquini M.C., Perez W.S., et al. HLA-identical sibling allogeneic transplants versus chemotherapy in acute myelogenous leukemia with t(8;21) in first complete remission: collaborative study between the German AML Intergroup and CIBMTR. Biol Blood Marrow Transplant 14 (2008) 187-196
6. Shi-Xia X., Xian-Hua T., and Xiang-Feng T. Unrelated umbilical cord blood transplantation and unrelated bone marrow transplantation in children with hematological disease: a meta-analysis. Pediatr Transplant 13 (2009) 278-284
7. Black S., Kushner I., and Samols D. C-reactive Protein. J Biol Chem 279 (2004) 48487-48490
8. Gabay C., and Kushner I. Acute-phase proteins and other systemic responses to inflammation. N Engl J Med 340 (1999) 448-454
9. Saarinen U.M., Strandjord S.E., Warkentin P.I., Cheung N.K., Lazarus H.M., and Coccia P.F. Differentiation of presumed sepsis from acute graft-versus-host disease by C-reactive protein and serum total IgE in bone marrow transplant recipients. Transplantation 44 (1987) 540-546
10. Fuji S., Kim S.W., Fukuda T., et al. Preengraftment serum C-reactive protein (CRP) value may predict acute graft-versus-host disease and nonrelapse mortality after allogeneic hematopoietic stem cell transplantation. Biol Blood Marrow Transplant 14 (2008) 510-517
11. Pihusch M., Pihusch R., Fraunberger P., et al. Evaluation of C-reactive protein, interleukin-6, and procalcitonin levels in allogeneic hematopoietic stem cell recipients. Eur J Haematol 76 (2006) 93-101
12. Schots R., Kaufman L., Van Riet I., et al. Monitoring of C-reactive protein after allogeneic bone marrow transplantation identifies patients at risk of severe transplant-related complications and mortality. Bone Marrow Transplant 22 (1998) 79-85
13. Schots R., Van Riet I., Othman T.B., et al. An early increase in serum levels of C-reactive protein is an independent risk factor for the occurrence of major complications and 100-day transplant-related mortality after allogeneic bone marrow transplantation. Bone Marrow Transplant 30 (2002) 441-446
14. Artz A.S., Wickrema A., Dinner S., et al. Pretreatment C-reactive protein is a predictor for outcomes after reduced-intensity allogeneic hematopoietic cell transplantation. Biol Blood Marrow Transplant 14 (2008) 1209-1216
15. Sauer M., Tiede K., Fuchs D., Gruhn B., Berger D., and Zintl F. Procalcitonin, C-reactive protein, and endotoxin after bone marrow transplantation: identification of children at high risk of morbidity and mortality from sepsis. Bone Marrow Transplant 31 (2003) 1137-1142
16. Gonzalez-Vicent M., Marin C., Madero L., Sevilla J., and Diaz M.A. Risk score for pediatric intensive care unit admission in children undergoing hematopoietic stem cell transplantation and analysis of predictive factors for survival. J Pediatr Hematol Oncol 27 (2005) 526-531
17. Schneider D.T., Lemburg P., Sprock I., Heying R., Gobel U., and Nurnberger W. Introduction of the oncological pediatric risk of mortality score (O-PRISM) for ICU support following stem cell transplantation in children. Bone Marrow Transplant 25 (2000) 1079-1086
18. Tse W.T., Duerst R., Schneiderman J., Chaudhury S., Jacobsohn D., and Kletzel M. Age-dependent pharmacokinetic profile of single daily dose i.v. busulfan in children undergoing reduced-intensity conditioning stem cell transplant. Bone Marrow Transplant 44 (2009) 145-156
19. Schneiderman J., Duerst R., Tse W., Thormann K., Kletzel M., and Jacobsohn D.A. Reduced intensity conditioning (RIC) and hematopoietic stem cell transplantation (HSCT) using photopheresis (ECP), fludarabine, and targeted single dose busulfan as an outpatient procedure in children: preliminary results. Biol Blood Marrow Transplant 13 Suppl 2 (2007)
20. Jacobsohn D.A., Hewlett B., Ranalli M., Seshadri R., Duerst R., and Kletzel M. Outcomes of unrelated cord blood transplants and allogeneic-related hematopoietic stem cell transplants in children with high-risk acute lymphocytic leukemia. Bone Marrow Transplant 34 (2004) 901-907
21. Przepiorka D., Weisdorf D., Martin P., et al. 1994 Consensus conference on acute GVHD grading. Bone Marrow Transplant 15 (1995) 825-828
22. Wang L.J., Chou P., Gonzalez-Ryan L., Huang W., Haut P.R., and Kletzel M. Evaluation of mixed hematopoietic chimerism in pediatric patients with leukemia after allogeneic stem cell transplantation by quantitative PCR analysis of variable number of tandem repeat and testis determination gene. Bone Marrow Transplant 29 (2002) 51-56
23. Prat C., Sancho J.M., Dominguez J., et al. Evaluation of procalcitonin, neopterin, C-reactive protein, IL-6 and IL-8 as a diagnostic marker of infection in patients with febrile neutropenia. Leuk Lymphoma 49 (2008) 1752-1761
24. El-Maghraby S.M., Moneer M.M., Ismail M.M., Shalaby L.M., and El-Mahallawy H.A. The diagnostic value of C-reactive protein, interleukin-8, and monocyte chemotactic protein in risk stratification of febrile neutropenic children with hematologic malignancies. J Pediatr Hematol Oncol 29 (2007) 131-136
25. Kitko C.L., Paczesny S., Yanik G., et al. Plasma elevations of tumor necrosis factor-receptor-1 at day 7 postallogeneic transplant correlate with graft-versus-host disease severity and overall survival in pediatric patients. Biol Blood Marrow Transplant 14 (2008) 759-765
26. Paczesny S., Krijanovski O.I., Braun T.M., et al. A biomarker panel for acute graft-versus-host disease. Blood 113 (2009) 273-278
27. Pulliam P.N., Attia M.W., and Cronan K.M. C-reactive protein in febrile children 1 to 36 months of age with clinically undetectable serious bacterial infection. Pediatrics 108 (2001) 1275-1279
28. Peltola H., and Jaakkola M. C-reactive protein in early detection of bacteremic versus viral infections in immunocompetent and compromised children. J Pediatr 113 (1988) 641-646
29. Shaoul R., Lahad A., Tamir A., Lanir A., and Srugo I. C reactive protein (CRP) as a predictor for true bacteremia in children. Med Sci Monit 14 (2008) CR255-CR261
30. Nimmerjahn F., and Ravetch J.V. Anti-inflammatory actions of intravenous immunoglobulin. Annu Rev Immunol 26 (2008) 513-533
31. Choi S.W., Kitko C.L., Braun T., et al. Change in plasma tumor necrosis factor receptor 1 levels in the first week after myeloablative allogeneic transplantation correlates with severity and incidence of GVHD and survival. Blood 112 (2008) 1539-1542