Protective and curative effects of Cocos nucifera inflorescence on alloxan-induced pancreatic cytotoxicity in rats

Indian Journal of Pharmacology

Volumn 44, Issue 5, 2012, Pages 555-559

  Renjith, Raveendran ^a   Rajamohan, Thankappan ^a  

^a UNIVERSITY OF KERALA   (India)

Author keywords

Alloxan; Cocos nucifera inflorescence; cytotoxicity; diabetes

Indexed keywords

FRUCTOSE BISPHOSPHATASE; GLUCOSE; GLUCOSE 6 PHOSPHATASE; GLUCOSE 6 PHOSPHATE DEHYDROGENASE; GLYCOGEN; GLYCOGEN PHOSPHORYLASE; GLYCOLYTIC ENZYME; HERBACEOUS AGENT; HEXOKINASE; PHOSPHOGLUCOMUTASE; PYRUVATE KINASE;

ALLOXAN DIABETES MELLITUS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; COCONUT; CONTROLLED STUDY; CYTOTOXICITY; ENZYME ACTIVITY; GLUCOSE BLOOD LEVEL; GLYCOGEN LIVER LEVEL; HISTOPATHOLOGY; INFLORESCENCE; MALE; NONHUMAN; PANCREAS ISLET; PHYTOCHEMISTRY; RAT;

ALLOXAN; COCOS NUCIFERA INFLORESCENCE; CYTOTOXICITY; DIABETES;

ALLOXAN; ANIMALS; COCOS; CYTOTOXINS; DIABETES MELLITUS, EXPERIMENTAL; MALE; PANCREAS; PLANT EXTRACTS; PROTECTIVE AGENTS; RANDOM ALLOCATION; RATS; RATS, SPRAGUE-DAWLEY; TREATMENT OUTCOME;

EID: 84866249553     PISSN: 02537613     EISSN: 19983751     Source Type: Journal    
DOI: 10.4103/0253-7613.100368     Document Type: Article

References (25)

1. Kameswara Rao B, Renuka Sudarshan P, Rajasekhar MD, Nagaraju N, Appa Rao Ch. Antidiabetic activity of Terminalia pallida fruit in alloxan induced diabetic rats. J Ethnopharmacol 2003;85:169-72.
2. Rerup CC. Drugs producing diabetes through damage of insulin secreting cells. Pharmacol Rev 1970;22:485-518.
3. Punitha SR, Rajendran K, Shirwaikar A, Shirwaikar A. Alcoholic stem extract of Coscinium fenestratum regulates carbohydrate metabolism and improves antioxidant status in strptozotocin-nicotinamide induced diabetic rats. Evid Based Complement Alternat Med 2005;2:375-81.
4. Hu X, Sato J, Oshida Y, Yu M, Bajotto G, Sato Y. Effect of Gosha-jinki-gan (Chinese herbal medicine: Niuche-sen-qi-wan) on insulin resistance in streptozotocin induced diabetic rats. Diabetes Res Clin Pract 2003;59:103-11.
5. Singh RP, Padmavathi B, Rao AR. Modulatory infl uence of Adhatoda vesica (Justica adhatoda) leaf extract on the enzyme of xenobiotic metabolism, antioxidant status and lipid peroxidation in mice. Mol Cel Biochem 2000;213:99- 109.
6. Salil G, Nevin KG, Rajamohan T. Arginine rich coconut kernel protein modulates diabetes in alloxan treated rats. Chem Biol Interact 2011;189:107-11.
7. Sindhurani JA, Rajamohan T. Effects of different levels of coconut fi ber on blood glucose, serum insulin and minerals in rats. Indian J Physiol Pharmacol 2000;44:97-100.
8. Harborne JB. Phytochemical methods. London: Chapman and Hall; 1998. p. 60-8.
9. Lott JA, Turner K. Evaluation of Trinder's glucose oxidase method for measuring glucose in serum and urine. Clin Chem 1975;21:1754-60.
10. Carroll NV, Longley RW, Roe JH. The determination of glycogen in liver and muscle by use of anthrone reagent. J Biol Chem 1956;220:583-93.
11. Crane RK, Sols A. The association of hexokinase with particulate fractions of brain and other tissue homogenates. J Biol Chem 1953;203:273-92.
12. Najjar VA. The isolation and properties of phosphoglucomutase. Methods Enzymol 1955;1:294.
13. Bucher T, Pfleiderer G. Pyruvate kinase from muscle. Methods Enzymol 1955;1:435-40.
14. Koide H, Oda T. Pathological occurrence of glucose-6-phosphatase in serum in liver diseases. Clin Chim Acta 1959;4:554-61.
15. Pontremoli S. Fructose-1, 6-diphosphatase: I. Rabbit liver (crystalline). Methods Enzymol 1966; 9: 625-631.
16. Singh VN, Venkatasubramanian TA, Viswanathan R. The glycolytic enzymes of guinea pig lung in experimental bagassosis. Biochem J 1961;78:728-32.
17. Kornberg A, Horecker BL, Smyrniotis PZ. Glucose-6-phosphate dehydrogenase, 6-phosphogluconic dehydrogenase. Methods Enzymol 1955;1:323-7.
18. Szkudelski T. The mechanism of alloxan and streptozotocin action in β-cells of the rat pancreas. Physiol Res 2001;50:536-46.
19. Golden S, Wals PA, Okajima F. Glycogen synthesis by hepatocytes from diabetic rats. Biochem J 1979;182:727-34.
20. Senthilkumar R, John S. Hypoglycaemic activity of marine cyanobacteria in alloxan induced diabetic rats. Pharmacologyonline 2008;2:704-14.
21. Bhavapriya V, Govidasamy S. Biochemical studies on the hypoglycemic effect of Aegle marmelos (Linn). Correa Ex. RoxB. In streptozotocin induced diabetic rats. Indian Drugs 2000;37:474-7.
22. Grover JK, Vats V, Rathi SS. Anti-hyperglycaemic effect of Eugenia jambolana and Tinospora cordifolia in experimental diabetes and their effects on key metabolic enzymes involved in carbohydrate metabolism. J Ethnopharmacol 2000;73:461- 70.
23. Baquer NZ, Gupta D, Raju J. Regulation of metabolic pathways in liver and kidney during experimental diabetes. Indian J Clin Biochem 1998;13:63-80.
24. Eddouks M, Khalidi A, Zeggwagh NA, Lemhadri A, Michel JB, Burcelin R. An understanding mechanistic approach of hypoglycemic plants. In: Eddouks M, editor. Advances in phytotherapy research. Trivandrum: Research Signpost Publishing House; 2009. p. 109-28.
25. Roesler WJ, Khanderwal RL. Quantitation of glycogen synthase and phosphorylase protein mouse liver. Correlation between enzymatic protein and enzymatic activity. Arch Biochem Biophys 1986;244:397-407.