A phase II study of UFT and leucovorin in combination with mitomycin C in patients with metastatic colorectal cancer

Acta Oncologica

Volumn 43, Issue 3, 2004, Pages 276-279

  Gyldenkerne, Niels ^a   Glimelius, Bengt ^b,c   Frödin, Jan Erik ^c   Kjaer, Mogens ^d   Pfeiffer, Per ^e   Hansen, Flemming ^f   Keldsen, Nina ^g   Sandberg, Erik ^h   Jakobsen, Anders ^a  

^a LILLEBAELT HOSPITAL   (Denmark)

^b UPPSALA UNIVERSITY HOSPITAL   (Sweden)

^c Radiumhemmet   (Sweden)

^d AALBORG UNIVERSITY HOSPITAL   (Denmark)

^e ODENSE UNIVERSITY HOSPITAL   (Denmark)

^f AARHUS UNIVERSITY HOSPITAL   (Denmark)

^g HERNING HOSPITAL   (Denmark)

^h Esbjerg Central Hospital   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

FLUOROURACIL; FOLINIC ACID; MITOMYCIN; UFT;

ADULT; AGED; ANOREXIA; ARTICLE; BONE PAIN; CANCER GROWTH; CANCER SURVIVAL; CLINICAL TRIAL; COLORECTAL CANCER; DEHYDRATION; DIARRHEA; DRUG EFFICACY; DRUG RESPONSE; DRUG SAFETY; DYSPNEA; FATIGUE; FEBRILE NEUTROPENIA; FEMALE; HUMAN; HYPERCALCEMIA; HYPONATREMIA; KIDNEY FAILURE; MAJOR CLINICAL STUDY; MALE; METASTASIS; NAUSEA AND VOMITING; NEUTROPENIA; PHASE 2 CLINICAL TRIAL; PRIORITY JOURNAL; THROMBOCYTOPENIA;

ADULT; AGED; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; COLORECTAL NEOPLASMS; DISEASE-FREE SURVIVAL; FEMALE; HUMANS; LEUCOVORIN; MALE; MIDDLE AGED; MITOMYCIN; NEOPLASM METASTASIS; TEGAFUR; TREATMENT OUTCOME; URACIL;

EID: 2942596466     PISSN: 0284186X     EISSN: None     Source Type: Journal    
DOI: 10.1080/02841860410028655     Document Type: Article

References (17)

1. Borner MM, Schöffski P, de Wit R, et al. Patient preference and pharmacokinetics of oral modulated UFT versus intravenous fluorouracil and Leucovorin: a randomised crossover trial in advanced colorectal cancer. Eur J Cancer 2002; 38: 349-58.
2. Pazdur R, Douilard J-Y, Sillings JR, et al. Multicenter phase II study of 5-fluorouracil (5-fluorouracil) or UFT in combination with Leucovorin (LV) in patients with metastatic colorectal cancer. ASCO 1999; 18: Abstract 1009.
3. Carmichael J, Popiela T, Radstone D, et al. Randomized comparative study of ORZEL (oral uracil tegafur (UFT)) plus Leucovorin (LV) versus parenteral 5-fluorouracil (5-fluorouracil) plus LV in patients with metastatic colorectal cancer. ASCO 1999; 18: Abstract 1015.
4. Hill M, Mackay H, Cunningham D, et al. Phase I/II study of oral uracil/tegafur (UFT®) Leucovorin and irinotecan in patients with advanced colorectal cancer. Ann Oncol 2002; 11 (suppl. 4): Abstract 193P.
5. Javier Dorta F, Feliu J, Vincent J, et al. Phase II clinical trial with the combination of oxaliplatin-UFT-1,-Leucovorin (OXA-UFT-1,LV) for the first line treatment of advanced colorectal cancer (ACC). Preliminary results (Oncopaz Cooperative Group - Spain). Ann Oncol 2002; 11(Suppl. 4): Abstract 220P.
6. Jakobsen A, Pfeiffer P, Hansen F, et al. dual modulation of UFT with Leucovorin and hydroxurea in metastatic colorectal cancer. Acta Oncologica 2001; 40: 63-6.
7. Moore GE, Bross ID, Ausman R, et al. Effects of mitomycin C (NSC-26980) in 346 patients with advanced cancer. Cancer Chemother Rep 1968; 52: 675-84.
8. Moertel C, Reitmeier R, Hahn R. Mitomycin C therapy in advanced gastrointestinal cancer. JAMA 1968; 204: 1045-8.
9. Rusello O, Romanini A, Civalleri D, et al. Time-dependent interactions between 5-fluorouracil and mitomycin C on a human colon cancer cell line, HCT-8, in vitro. EUR J Cancer Clin Oncol 1989; 25: 571-2.
10. Krauss S, Sonoda T, Solomon A. Treatment of advanced gastrointestinal cancer with 5-fluorouracil and mitomycin C. Cancer 1979; 43: 1598-603.
11. Richards F, Case LD, White DR, et al. Combination chemotherapy (5-fluorouracil, methyl-CCNU, mitomycin C) versus 5-fluorouracil alone for advanced previously untreated colorectal carcinoma. A phase III study of the Piedmont Oncology Association. J Clin Oncol 1986; 4: 565-70.
12. Ross P, Norman A, Cunningham D, et al. A prospective randomized trial of protracted venous infusion 5-fluorouracil with or without mitomycin C in advanced colorectal cancer. Ann Oncol 1997; 8: 995-1001.
13. Epidermoid Anal Cancer: Results from the UKCCCR Randomised Trial of Radiotherapy Alone Versus Radiotherapy, 5-Fluorouracil, and mitomycin. Lancet. 1996; 348: 1049-54.
14. Chan AK, Wong AO, Langevin J, et al. Preoperative chemotherapy and pelvic radiation for tethered or fixed rectal cancer: a phase II dose escalation study. Int J Radiat Oncol Biol Phys 2000; 48: 843-56.
15. Herrmann R. 5-fluorouracil and mitomycin C in colorectal cancer: unacceptable conclusion. Ann Oncol 1998; 9(2): 230.
16. Meta-analysis Group in Cancer. Efficacy of intravenous continuous infusion of fluorouracil compared with bolus administration in advanced colorectal cancer. J Clin Oncol 1998; 16: 301-8.
17. Ikeda E, Kodaira S, Teramoto T, et al. Optimal dosage of UFT+ MMC combination chemotherapy for advanced colorectal cancer - phase I/II study of combination chemotherapy of MMC with 2-week intervals and intermittent UFT administration - Study Group of UFTM Therapy for Advanced colorectal cancer. Gan To Kagaku Ryoho 1998; 23: 1291-8.