Synthesis and pharmacological evaluation of indolinone derivatives as novel ghrelin receptor antagonists

Bioorganic and Medicinal Chemistry

Volumn 20, Issue 18, 2012, Pages 5623-5636

  Puleo, Letizia ^a   Marini, Pietro ^a   Avallone, Roberta ^a   Zanchet, Marco ^a   Bandiera, Silvio ^a   Baroni, Marco ^a   Croci, Tiziano ^a  

^a Exploratory Unit   (Italy)

Author keywords

Ghrelin; GHSR1a antagonists; Indolinone derivatives

Indexed keywords

(1 ETHYLPIPERIDIN 4 YL)ACETIC ACID; (1 ETHYLPIPERIDIN 4 YL)ACETONITRILE; (1 ETHYLPIPERIDIN 4 YLIDENE)ACETONITRILE; 3 AMINO 5,6 DICHLORO 1,3 DIHYDRO 3 (4 CHLOROPHENYL)INDOLE 2 ONE; 3 BROMO 5,6 DICHLORO 1,3 DIHYDRO 3 (4 CHLOROPHENYL)INDOLE 2 ONE; 3 HYDROXY 4,6 DICHLORO 1,3 DIHYDRO 3 (3,4 DICHLOROPHENYL)INDOL 2 ONE; 3,4,6 TRICHLORO 1,3 DIHYDRO 3 (3,4 CHLOROPHENYL)INDOL 2 ONE; 4 CHLORO 5 METHYL 1,3 DIHYDRO 3 (4 CHLOROPHENYL)INDOL 2 ONE; 4 CHLORO N (3,4,5 TRICHLOROPHENYL)MANDELAMIDE; 4 CHLORO O ACYL MANDELIC; 4,5,6 TRICHLORO 1,3 DIHYDRO 3 (4 CHLOROPHENYL)INDOL 2 ONE; 5 CHLORO 6 METHYL 1,3 DIHYDRO 3 (4 CHLOROPHENYL)INDOL 2 ONE; 5,6 DICHLORO 1,3 DIHYDRO 3 (4 CHLOROPHENYL)INDOLE 2 ONE; 5,6 DICHLORO 3 (2 HYDROXY 1 PHENYLETHYL)AMINO 1,3 DIHYDRO 3 (4 CHLOROPHENYL)INDOLE 2 ONE; GHRELIN; GHRELIN RECEPTOR; HORMONE RECEPTOR BLOCKING AGENT; INDOLINONE DERIVATIVE; N [4 `CHLORO 5 METHYL 3 (4 CHLOROPHENYL) 2 OXO 2,3 DIHYDRO 1H INDOL 3 YL] 2 (1 METHYL PIPERAZIN 4 YL)ACETAMIDE; N [4,6 DICHLORO 3 (3,4 DICHLOROPHENYL) 2 OXO 2,3 DIHYDRO 1H INDOL 3 YL] 2 (1 ETHYL PIPERIDIN 4 YL)ACETAMIDE; N [4,6 DICHLORO 3 (3,4 DICHLOROPHENYL) 2 OXO 2,3 DIHYDRO 1H INDOL 3 YL] 2 (1 METHYL PIPERAZIN 4 YL)ACETAMIDE; N [4,6 DICHLORO 3 (3,4 DICHLOROPHENYL) 2 OXO 2,3 DIHYDRO 1H INDOL 3 YL] 2 (4 N DIMETHYLAMINO PIPERIDIN 1 YL)ACETAMIDE; N [5,6 DICHLORO 3 (4 CHLOROPHENYL) 2 OXO 2,3 DIHYDRO 1H INDOL 3 YL] 2 (METHYL PIPERAZIN 1 YL)ACETAMIDE; N [5,6 DICHLORO 3 (4 CHLOROPHENYL) 2 OXO 2,3 DIHYDRO 1H INDOL 3 YL] 2 N METHYL (2 N DIMETHYL)ETHYL ACETAMIDE; N [6 CHLORO 3 (4 CHLOROPHENYL) 2 OXO 2,3 DIHYDRO 1H INDOL 3 YL] 2 (1 METHYL PIPERAZIN 4 YL)ACETAMIDE; N [6 CHLORO 5 METHYL 3 (3,4 DICHLOROPHENYL) 2 OXO 2,3 DIHYDRO 1H INDOL 3 YL] 2 (4 METHYL PIPERAZIN 1 YL)ACETAMIDE; N [6 CHLORO 5 METHYL 3 (4 CHLOROPHENYL) 2 OXO 2,3 DIHYDRO 1H INDOL 3 YL] 2 (4 BENZYL PIPERAZIN 1 YL)ACETAMIDE; N [6 CHLORO 5 METHYL 3 (4 CHLOROPHENYL) 2 OXO 2,3 DIHYDRO 1H INDOL 3 YL] 2 [4 (4 PYRIDYL)PIPERAZIN 1 YL]ACETAMIDE; N [6 CHLORO 5 METHYL 3 (4 CHLOROPHENYL) 2 OXO 2,3 DIHYDRO 1H INDOL 3 YL] 2 PIPERAZINYL ACETAMIDE; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DIET RESTRICTION; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG CLEARANCE; DRUG DISTRIBUTION; DRUG DOSE COMPARISON; DRUG EFFICACY; DRUG EXCRETION; DRUG IDENTIFICATION; DRUG MECHANISM; DRUG METABOLISM; DRUG PENETRATION; DRUG POTENCY; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; FOOD INTAKE; GLUCOSE TOLERANCE; GLUCOSE TOLERANCE TEST; HORMONE ACTION; HORMONE BLOOD LEVEL; HORMONE INHIBITION; HUMAN; HUMAN TISSUE; IC 50; IN VITRO STUDY; IN VIVO STUDY; MALE; MONOTHERAPY; NONHUMAN; NUCLEOTIDE SEQUENCE; STOMACH EMPTYING; STRUCTURE ACTIVITY RELATION;

ANIMALS; CHO CELLS; CRICETINAE; DOSE-RESPONSE RELATIONSHIP, DRUG; EATING; GLUCOSE TOLERANCE TEST; HUMANS; INDOLES; MALE; MICE; MICE, INBRED C57BL; MOLECULAR STRUCTURE; RECEPTORS, GHRELIN; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84866244706     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2012.07.018     Document Type: Article

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