The impact of impurities in various crude A. annua extracts on the analysis of artemisinin by liquid chromatographic methods

Journal of Pharmaceutical and Biomedical Analysis

Volumn 70, Issue , 2012, Pages 136-142

  Pilkington, Josh L ^a   Preston, Chris ^b   Gomes, Rachel L ^a  

^a UNIVERSITY OF NOTTINGHAM   (United Kingdom)

^b Bio Project Consulting Ltd   (United Kingdom)

Author keywords

Artemisia annua; Artemisinin; Extract reconstitution; HPLC UV; Selectivity

Indexed keywords

ACETIC ACID ETHYL ESTER; ACETONITRILE; ALCOHOL; ARTEMISIA ANNUA EXTRACT; ARTEMISININ; HEXANE;

ARTEMISIA ANNUA; ARTICLE; DRUG IMPURITY; FLOW RATE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; PRIORITY JOURNAL; SOLVENT EFFECT; SOLVENT EXTRACTION; TEMPERATURE; ULTRAVIOLET SPECTROSCOPY;

ACETATES; ACETONITRILES; ARTEMISIA ANNUA; ARTEMISININS; CALIBRATION; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DRUG CONTAMINATION; ETHANOL; HEXANES; LACTONES; PLANT EXTRACTS; PLANT LEAVES; REFERENCE STANDARDS; SOLUBILITY; SOLVENTS; SPECTROPHOTOMETRY, ULTRAVIOLET;

EID: 84866242626     PISSN: 07317085     EISSN: 1873264X     Source Type: Journal    
DOI: 10.1016/j.jpba.2012.06.015     Document Type: Article

References (21)

1. Lapkin A.A., Plucinski P.K., Cutler M. Comparative assessment of technologies for extraction of artemisinin. J. Nat. Prod. 2006, 69:1653-1664.
2. WHO Facts on ACTs (Artemisinin-based Combination Therapies), (accessed 13/02/2012). http://www.searo.who.int/LinkFiles/Drug_Policy_RBMInfosheet_9.pdf.
3. Roll Back Malaria, The Global Malaria Action Plan, (accessed 13/02/2012). http://www.rbm.who.int/gmap/gmap.pdf.
4. WHO Global Plan for Artemisinin Resistance Containment, (accessed 12/02/2012). http://www.who.int/malaria/publications/atoz/artemisinin_resistance_containment_2011.pdf.
5. Kohler M., Haerdi W., Christen P., Veuthey J.L. Supercritical fluid extraction and chromatography of artemisinin and artemisinic acid. An improved method for the analysis of Artemisia annua samples. Phytochem. Anal. 1997, 8:223-227.
6. Quispe-Condori S., Sanchez D., Foglio M.A., Rosa P.T.V., Zetzl C., Brunner G., Meireles M.A.A. Global yield isotherms and kinetic of artemisinin extraction from Artemisia annua L. leaves using supercritical carbon dioxide. J. Supercrit. Fluids 2005, 36:40-48.
7. Tzeng T.C., Lin Y.L., Jong T.T., Chang C.M.J. Ethanol modified supercritical fluids extraction of scopoletin and artemisinin from Artemisia annua L. Sep. Purif. Technol. 2007, 56:18-24.
8. Hao J.Y., Han W., Huang S.D., Xue B.Y., Deng X. Microwave-assisted extraction of artemisinin from Artemisia annua L. Sep. Purif. Technol. 2002, 28:191-196.
9. Diawara H.Z., Gbaguidi F., Evrard B., Leclercq J.Q., Moudachirou M., Debrus B., Hubert P., Rozet E. Validation, transfer and measurement uncertainty estimation of an HPLC-UV method for the quantification of artemisinin in hydro alcoholic extracts of Artemisia annua L. J. Pharm. Biomed. Anal. 2011, 56:7-15.
10. Stringham R.W., Lynam K.G., Mrozinski P., Kilby G., Pelczer I., Kraml C. High performance liquid chromatographic evaluation of artemisinin, raw material in the synthesis of artesunate and artemether. J. Chromatogr. A 2009, 1216:8918-8925.
11. Lapkin A.A., Walker A., Sullivan N., Khambay B., Mlambo B., Chemat S. Development of HPLC analytical protocols for quantification of artemisinin in biomass and extracts. J. Pharm. Biomed. Anal. 2009, 49:908-915.
12. Ferreira J.F.S., Gonzalez J.M. Analysis of underivatized artemisinin and related sesquiterpene lactones by high-performance liquid chromatography with ultraviolet detection. Phytochem. Anal. 2009, 20:91-97.
13. Erdemoglu N., Orhan I., Kartal M., Adiguzel N., Bani B. Determination of artemisinin in selected Artemisia L. species of Turkey by reversed phase HPLC. Rec. Nat. Prod. 2007, 1:36-43.
14. Peng C.A., Ferreira J.F.S., Wood A.J. Direct analysis of artemisinin from Artemisia annua L. using high-performance liquid chromatography with evaporative light scattering detector, and gas chromatography with flame ionization detector. J. Chromatogr. A 2006, 1133:254-258.
15. Quennoz M., Bastian C., Simonnet X., Grogg A.F. Quantification of the total amount of artemisinin in leaf samples by thin layer chromatography. Chimia 2010, 64:755-757.
16. Castilho P.C., Gouveia S.C., Rodrigues A.I. Quantification of artemisinin in Artemisia annua extracts by H-1-NMR. Phytochem. Anal. 2008, 19:329-334.
17. Wang M.F., Park C.H., Wu Q.L., Simon J.E. Analysis of artemisinin in Artemisia annua L. by LC-MS with selected ion monitoring. J. Agric. Food Chem. 2005, 53:7010-7013.
18. Woerdenbag H.J., Pras N., Bos R., Visser J.F., Hendriks H., Malingre T.M. Analysis of artemisinin and related sesquiterpenoids from Artemisia-annua L. by combined gas-chromatography mass-spectrometry. Phytochem. Anal. 1991, 2:215-219.
19. Wang L.-H., Song Y.-T., Chen Y., Cheng Y.-Y. Solubility of artemisinin in ethanol plus water from (278.2 to 343.2)K. J. Chem. Eng. Data 2007, 52:757-758.
20. Brisibe E.A., Uyoh E.A., Brisibe F., Magalhaees P.M., Ferreira J.F.S. Building a golden triangle for the production and use of artemisinin derivatives against falciparum malaria in Africa. Afr. J. Biotechnol. 2008, 7:4884-4896.
21. Christen P., Veuthey J.L. New trends in extraction, identification and quantification of artemisinin and its derivatives. Curr. Med. Chem. 2001, 8:1827-1839.