Ethanol modified supercritical fluids extraction of scopoletin and artemisinin from Artemisia annua L.

Separation and Purification Technology

Volumn 56, Issue 1, 2007, Pages 18-24

  Tzeng, Tzu Ching ^a   Lin, Young Lung ^a   Jong, Ting Ting ^a   Chang, Chieh Ming J ^a  

^a NATIONAL CHUNG HSING UNIVERSITY   (Taiwan)

Author keywords

Artemisia annua L.; Artemisinin; Column purification; Scopoletin; Supercritical carbon dioxide

Indexed keywords

CARBON DIOXIDE; COLUMN CHROMATOGRAPHY; ETHANOL; ORGANIC SOLVENTS; PLANTS (BOTANY); SILICA GEL; SUPERCRITICAL FLUID EXTRACTION;

ARTEMISININ; COLUMN PURIFICATION; SCOPOLETIN; SUPERCRITICAL CARBON DIOXIDE;

HORMONES;

ARTEMISIA ANNUA;

EID: 34248660841     PISSN: 13835866     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.seppur.2007.01.010     Document Type: Article

References (24)

1. Klayman D.L., and Qinghaosu. Artemisinin: an antimalarial drug from China. Science 1228 (1985) 1049-1055
2. Lin A.J., Klayman D.L., and Hoch M.J. Thermal rearrangement and decomposition products of artemisinin Qinghaosu. J. Org. Chem. 50 (1985) 4504-4508
3. Luo X.D., Herman J.C.Y., and Brossi A. The chemistry of drugs. VI. Thermal decomposition of Qinghaosu. Heterocycles 23 4 (1985) 881-887
4. Christen P., and Veuthey J.L. New trends in extraction, identification and quantification of artemisinin and its derivatives. Curr. Med. Chem. 8 (2001) 1827-1839
5. Zheng G.Q. Cytotoxic terpenoids and flavonoids from Artemisia annua. Planta Med. 60 (1994) 54-57
6. Fishwick F., McLean W.G., Edwards G., and Ward S.A. The toxicity of artemisinin and related compounds on neuronal and glial cells in culture. Chem.-Biol. Inter. 96 (1995) 263-271
7. Vasconcelos J.M.J., Silva A.M.S., and Cavalejro J.A.S. Chromones and flavanones from artemisia campestris subsp. Maritima. Phytochemistry 49 5 (1998) 1421-1424
8. Ojewoleand J.A.O., and Adesina S.K. Cardiovascular and neuromuscular actions of scopoletin from fruit of tetrapleura tetraptera. Planta Med. 49 (1983) 99-102
9. Cassady J.M., Ojima N., Chang C.J., and McLaughlin J.L. An investigation of the antitumor activity of micromelum integerrimum Rutaceae. Phytochemistry 42 3 (1979) 274-278
10. Kang T.H., Pae H.O., Jeong S.J., Yoo J.C., Choi B.M., Jun C.D., Chung H.T., Miyanoto T., Higuchi R., and Kim Y.C. Scopoletin: an inducible nitric oxide synthesis inhibitory active constituent from artemisia feddei. Planta Med. 65 (1999) 400-403
11. Erazo S., García R., Backhouse N., Lemus I., Delporte C., and Andrade C. Phytochemical and biological study of Radal Lomatia hirsute (Proteaceae). J. Ethnopharmacol. 57 (1997) 81-83
12. Churngchow N., and Rattarasarn M. Biosynthesis of scopoletin in Hevea brasiliensis leaves inoculated with phytophthora palmivora. J. Plant Physiol. 158 7 (2001) 875-882
13. Minamikawa T., Akazawa T., and Uritani I. Analytical study of umbelliferone and scopoletin synthesis in sweet potato roots infected by ceratocystis fimbriata. Plant Physiol. 38 5 (1963) 493-497
14. Jurd L., Corse J., King A.D., Bayne J.R.H., and Mihara K. Antimicrobial Properties of 6,7-dihydroxy-7,8-dihydroxy-6-hydroxy-and 8-hydroxycoumarins. Phytochemistry 10 (1971) 2971-2974
15. Jarboe C.H., Zirvi K.A., Nicholsox J.A., and Schmidt C.M. Scopoletin, and antispasmodic component of fiburnum poulus and prunifolium. J. Med. Chem. 10 (1967) 488-489
16. Lin Y.L., Yang Z.C., Hsu H.C., Hsu S.L., and Chang C.J. Response surface methodology to optimize supercritical fluids extraction of artemisinin and the effects on rat hepatic stellate cell in vitro. J. Supercrit. Fluids 39 (2006) 48-53
17. Chang L.H., Jong T.T., Huang H.S., and Chang C.J. Purifying turmerones of the turmeric oil extracted from Curcuma longa Linn using supercritical carbon dioxide. Sep. Purif. Technol. 47 (2006) 119-125
18. Y.N. Lee, C.R. Chen, H.L. Yang, C.C. Lin, C.J. Chang, Isolation and purification of 3,5-diprenyl-4-hydroxycinnamic acid (Artepillin C) in Brazilian Propolis by supercritical fluid extractions, Sep. Purif. Technol. (available online September 28, 2006).
19. Kohler M., Haerdi W., Christen P., and Veuthey J.L. Extraction of artemisinin and artemisinic acid from Artemisia annua L. using supercritical carbon dioxide. J. Chromatogr. A 785 (1997) 353-360
20. Van Nijlen T., Brennan K., Van den Mooter G., Blaton N., Kinget R., and Augustijns P. Improvement of the dissolution rate of artemisinin by means of supercritical fluid technology and solid dispersions. Int. J. Pharm. 254 (2003) 173-181
21. Quispe-Condori S., Sanchez D., Foglio M.A., Rosa P.T.V., Zetzl C., Brunner G., Angela M., and Meireles A. Global yield isotherms and kinetic of artemisinin extraction from Artemisia annua L. leaves using supercritical carbon dioxide. J. Supercrit. Fluids 36 (2005) 40-48
22. Sajfrtová M., Sovová H., Opletal L., and Bártlová M. Near-critical extraction of β-sitosterol and scopoletin from stinging nettle roots. J. Supercrit. Fluids 35 (2005) 111-118
23. Chiu K.L., Cheng Y.C., Chen J.H., Chang C.J., and Yang P.W. Supercritical fluids extraction of Ginkgo ginkgolides and flavonoids. J. Supercrit. Fluids 24 (2002) 77-87
24. Pöhler H., and Kiran E. Volumetric properties of carbon dioxide + ethanol at high pressures. J. Chem. Eng. Data 42 (1997) 384-388