Safety evaluation of longan seed extract: Acute and repeated oral administration

Food and Chemical Toxicology

Volumn 50, Issue 11, 2012, Pages 3949-3955

  Worasuttayangkurn, Luksamee ^a   Watcharasit, Piyajit ^a,b   Rangkadilok, Nuchanart ^a,b   Suntararuks, Sumitra ^a   Khamkong, Pattaya ^a   Satayavivad, Jutamaad ^a,b  

^a Chulabhorn Research Institute   (Thailand)

^b Research and Innovation   (Thailand)

Author keywords

Longan seed extract; Oral administration; Toxicity

Indexed keywords

LONGAN SEED EXTRACT; PLANT EXTRACT; UNCLASSIFIED DRUG;

ACUTE TOXICITY; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BLOOD ANALYSIS; BODY WEIGHT; CONTROLLED STUDY; DIMOCARPUS LONGAN; DOSE RESPONSE; DRUG DOSE COMPARISON; DRUG EFFECT; DRUG SAFETY; EOSINOPHIL COUNT; FEMALE; FOOD INTAKE; HISTOPATHOLOGY; MALE; MOUSE; NONHUMAN; ORGAN WEIGHT; PHYTOCHEMISTRY; SAPINDACEAE; SEX DIFFERENCE;

ADMINISTRATION, ORAL; ANIMALS; BODY WEIGHT; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG ADMINISTRATION SCHEDULE; EOSINOPHILS; FEMALE; MALE; MICE; ORGAN SIZE; PLANT EXTRACTS; RATS; RATS, WISTAR; SAPINDACEAE; SEEDS; TOXICITY TESTS, ACUTE;

ANIMALIA; DIMOCARPUS LONGAN; RATTUS;

EID: 84866166714     PISSN: 02786915     EISSN: 18736351     Source Type: Journal    
DOI: 10.1016/j.fct.2012.07.068     Document Type: Article

References (19)

1. Cheng J.T., Lin T.C., Hsu F.L. Antihypertensive effect of corilagin in the rat. Can. J. Physiol. Pharmacol. 1995, 73:1425-1429.
2. Chung Y.C., Lin C.C., Chou C.C., Hsu C.P. The effect of Longan seed polyphenols on colorectal carcinoma cells. Eur. J. Clin. Invest. 2010, 40:713-721.
3. Diplock A.T., Charleux J.-L., Crozier-Willi G., Kok F.J., Rice-Evans C., Roberfroid M., Stahl W., Viña-Ribes J. Functional food science and defence against reactive oxidative species. Br. J. Nutr. 1998, 80:S77-S112.
4. Halliwell B. Antioxidants and human disease: a general introduction. Nutr. Rev. 1997, 55:S44-S49.
5. Hsu F.L., Lu F.H., Cheng J.T. Influence of acetonylgeraniin, a hydrolyzable tannin from Euphoria longana, on orthostatic hypotension in a rat model. Planta Med. 1994, 60:297-300.
6. Menzel, C., Watson, B., Simpson, D., 1995. Longan (Euphoria longan), In: Fletcher, R. (Ed.), The Australia New Crops Newsletter, School of Land and Food Sciences, The University of Queensland Gatton College, Brisbane, (4).
7. Morton J.F. Longan. Fruits of Warm Climates 1987, 259-262. Miami, FL. J.F. Morton (Ed.).
8. OECD, 1995. OECD Guideline for the Testing of Chemicals, Repeated Dose 28-day Oral Toxicity Study in Rodents, No. 407, 1-8.
9. OECD, 1998. OECD Guideline for the Testing of Chemicals, Repeated Dose 90-day Oral Toxicity Study in Rodents, No. 408, 1-10.
10. OECD, 2001. OECD Guideline for Testing of Chemicals, Acute Oral Toxicity-Fixed Dose Procedure, No. 420, 1-14.
11. Rangkadilok N., Worasuttayangkurn L., Bennett R.N., Satayavivad J. Identification and quantification of polyphenolic compounds in longan (Euphoria longana Lam.) fruit. J. Agric. Food Chem. 2005, 53:1387-1392.
12. Rangkadilok N., Sitthimonchai S., Worasuttayangkurn L., Mahidol C., Ruchirawat M., Satayavivad J. Evaluation of free radical scavenging and antityrosinase activities of standardized longan fruit extract. Food Chem. Toxicol. 2007, 45:328-336.
13. Rangkadilok N., Tongchusak S., Boonhok R., Chaiyaroj S.C., Junyaprasert V.B., Buajeeb W., Akanimanee J., Raksasuk T., Suddhasthira T., Satayavivad J. In vitro antifungal activities of longan (Dimocarpus longan Lour.) seed extract. Fitoterapia 2012, 83:545-553.
14. Rangsriwong P., Rangkadilok N., Satayavivad J., Goto M., Shotipruk A. Subcritical water extraction of polyphenolic compounds from Terminalia chebula Retz. fruits. Sep. Purif. Technol. 2009, 66:51-56.
15. Soong Y.Y., Barlow P.J. Antioxidant activity and phenolic content of selected fruit seeds. Food Chem. 2004, 88:411-417.
16. Soong Y.Y., Barlow P.J. Isolation and structure elucidation of phenolic compounds from longan (Dimocarpus longan Lour.) seed by high-performance liquid chromatography-electrospray ionization mass spectrometry. J. Chromatogr. A 2005, 1085:270-277.
17. Soong Y.Y., Barlow P.J. Quantification of gallic acid and ellagic acid from longan (Dimocarpus longan Lour.) seed and mango (Mangifera indica L.) kernel and their effects on antioxidant activity. Food Chem. 2006, 97:524-530.
18. Zheng G., Xu L., Wu P., Xie H., Jiang Y., Chen F., Wei X. Polyphenols from longan seeds and their radical-scavenging activity. Food Chem. 2009, 116:433-436.
19. Zheng S.Q., Jiang F., Gao H.Y., Zheng J.G. Preliminary observations on the antifatigue effects of longan (Dimocarpus longan Lour.) seed polysaccharides. Phytother. Res. 2010, 24:622-624.