Paradoxical effects of the endocannabinoid uptake inhibitor VDM11 on accumbal neural encoding of reward predictive cues

Synapse

Volumn 66, Issue 11, 2012, Pages 984-988

  Oleson, Erik B ^a   Cheer, Joseph F ^a  

^a UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

Author keywords

Anandamide; Brain stimulation reward; Endocannabinoid uptake; Medium spiny neuron; Rat

Indexed keywords

ENDOCANNABINOID; N (4 HYDROXY 2 METHYLPHENYL)ARACHIDONAMIDE;

ANIMAL EXPERIMENT; ARTICLE; BRAIN DEPTH STIMULATION; INSTRUMENTAL CONDITIONING; MALE; NONHUMAN; NUCLEUS ACCUMBENS; PRIORITY JOURNAL; RAT; REWARD; TASK PERFORMANCE;

ANIMALS; ARACHIDONIC ACIDS; BEHAVIOR, ANIMAL; CUES; ELECTROENCEPHALOGRAPHY; ENDOCANNABINOIDS; MALE; NERVE NET; NUCLEUS ACCUMBENS; RATS; RATS, SPRAGUE-DAWLEY; REWARD;

EID: 84866152755     PISSN: 08874476     EISSN: 10982396     Source Type: Journal    
DOI: 10.1002/syn.21587     Document Type: Article

References (33)

1. Adamczyk P, McCreary A, Przegalinski E, Mierzejewski P, Bienkowski P, Filip M. 2009. The effects of fatty acid amide hydrolase inhibitors on maintenance of cocaine and food self-administration and on reinstatement of cocaine-seeking and food-taking behavior in rats. Acta Physiol Pol 12: 119.
2. Bisogno T, MacCarrone M, De Petrocellis L, Jarrahian A, Finazzi-Agro A, Hillard C, Di Marzo V. 2001. The uptake by cells of 2-arachidonoylglycerol, an endogenous agonist of cannabinoid receptors. Eur J Biochem 268: 1982-1989.
3. Bortolato M, Campolongo P, Mangieri RA, Scattoni ML, Frau R, Trezza V, La Rana G, Russo R, Calignano A, Gessa GL, Cuomo V, Piomelli D. 2006. Anxiolytic-like properties of the anandamide transport inhibitor AM404. Neuropsychopharmacology 31: 2652-2659.
4. Cahill K, Ussher M. 2007. Cannabinoid type 1 receptor antagonists (rimonabant) for smoking cessation. Cochrane Database Syst Rev 4: CD005353.
5. Cheer JF, Heien ML, Garris PA, Carelli RM, Wightman RM. 2005. Simultaneous dopamine and single-unit recordings reveal accumbens GABAergic responses: Implications for intracranial self-stimulation. Proc Natl Acad Sci USA 102: 19150-19155.
6. Di Marzo V. 2009. The endocannabinoid system: its general strategy of action, tools for its pharmacological manipulation and potential therapeutic exploitation. Pharmacol Res 60: 77-84.
7. Di Marzo V. 2010. Anandamide serves two masters in the brain. Nat Neurosci 13: 1446-1448.
8. Di S, Boudaba C, Popescu IR, Weng FJ, Harris C, Marcheselli VL, Bazan NG, Tasker JG. 2005. Activity-dependent release and actions of endocannabinoids in the rat hypothalamic supraoptic nucleus. J Physiol 569: 751-760.
9. Fegley D, Kathuria S, Mercier R, Li C, Goutopoulos A, Makriyannis A, Piomelli D. 2004. Anandamide transport is independent of fatty-acid amide hydrolase activity and is blocked by the hydrolysis-resistant inhibitor AM1172. Proc Natl Acad Sci USA 101: 8756-8761.
10. Fu J, Bottegoni G, Sasso O, Bertorelli R, Rocchia W, Masetti M, Guijarro A, Lodola A, Armirotti A, Garau G. 2011. A catalytically silent FAAH-1 variant drives anandamide transport in neurons. Nat Neurosci 15: 64-69.
11. Gamaleddin I, Guranda M, Goldberg SR, Lefoll B. 2011. The selective anandamide transport inhibitor VDM11 attenuates reinstatement of nicotine seeking induced by nicotine associated cues and nicotine priming, but does not affect nicotine-intake. Br J Pharmacol 164: 1652-1681.
12. Gutierrez-Lopez M, Llopis N, Feng S, Barrett D, O'Shea E, Colado M. 2010. Involvement of 2, arachidonoyl glycerol in the increased consumption of and preference for ethanol of mice treated with neurotoxic doses of methamphetamine. Br J Pharmacol 160: 772-783.
13. Hajos N, Kathuria S, Dinh T, Piomelli D, Freund TF. 2004. Endocannabinoid transport tightly controls 2-arachidonoyl glycerol actions in the hippocampus: Effects of low temperature and the transport inhibitor AM404. Eur J Neurosci 19: 2991-2996.
14. Hillard CJ, Shi L, Tuniki VR, Falck JR, Campbell WB. 2007. Studies of anandamide accumulation inhibitors in cerebellar granule neurons: Comparison to inhibition of fatty acid amide hydrolase. JMol Neurosci 33: 18-24.
15. Justinova Z, Solinas M, Tanda G, Redhi GH, Goldberg SR. 2005. The endogenous cannabinoid anandamide and its synthetic analog R(+)-methanandamide are intravenously self-administered by squirrel monkeys. J Neurosci 25: 5645-5650.
16. Justinova Z, Yasar S, Redhi GH, Goldberg SR. 2011. The endogenous cannabinoid 2-arachidonoylglycerol is intravenously self-administered by squirrel monkeys. J Neurosci 31: 7043-7048.
17. Ligresti A, Morera E, Van Der Stelt M, Monory K, Lutz B, Ortar G, Di Marzo V. 2004. Further evidence for the existence of a specific process for the membrane transport of anandamide. Biochem J 380: 265-272.
18. Melis M, Perra S, Muntoni AL, Pillolla G, Lutz B, Marsicano G, Di Marzo V, Gessa GL, Pistis M. 2004. Prefrontal cortex stimulation induces 2-arachidonoyl-glycerol-mediated suppression of excitation in dopamine neurons. J Neurosci 24: 10707-10715.
19. Mogenson GJ, Jones DL, Yim CY. 1980. From motivation to action: Functional interface between the limbic system and the motor system. Prog Neurobiol 14: 69-97.
20. Nicola SM, Yun IA, Wakabayashi KT, Fields HL. 2004. Cue-evoked firing of nucleus accumbens neurons encodes motivational significance during a discriminative stimulus task. J Neurophysiol 91: 1840-1865.
21. Oleson EB, Beckert MV, Morra JT, Lansink CS, Cachope R, Abdullah RA, Loriaux AL, Schetters D, Pattij T, Roitman MF. 2012. Endocannabinoids shape accumbal encoding of cue-motivated behavior via CB1 receptor activation in the ventral tegmentum. Neuron 73: 360-373.
22. Ronesi J, Gerdeman GL, Lovinger DM. 2004. Disruption of endocannabinoid release and striatal long-term depression by postsynaptic blockade of endocannabinoid membrane transport. J Neurosci 24: 1673-1679.
23. Savinainen JR, Jarvinen T, Laine K, Laitinen JT. 2001. Despite substantial degradation, 2-arachidonoylglycerol is a potent full efficacy agonist mediating CB(1) receptor-dependent G-protein activation in rat cerebellar membranes. Br J Pharmacol 134: 664-672.
24. Scheen AJ. 2008. CB1 receptor blockade and its impact on cardiometabolic risk factors: Overview of the RIO programme with rimonabant. J Neuroendocrinol 20: 139-146.
25. Scherma M, Justinova Z, Zanettini C, Panlilio LV, Mascia P, Fadda P, Fratta W, Makriyannis A, Vadivel SK, Gamaleddin I, Le Foll B, Goldberg SR. 2011. The anandamide transport inhibitor AM404 reduces the rewarding effects of nicotine and nicotine-induced dopamine elevations in the nucleus accumbens shell in rats. Br J Pharmacol 165: 2539-2548.
26. Scherma M, Medalie J, Fratta W, Vadivel SK, Makriyannis A, Piomelli D, Mikics E, Haller J, Yasar S, Tanda G. 2008. The endogenous cannabinoid anandamide has effects on motivation and anxiety that are revealed by fatty acid amide hydrolase (FAAH) inhibition. Neuropharmacology 54: 129-140.
27. Soria-Gomez E, Matias I, Rueda-Orozco PE, Cisneros M, Petrosino S, Navarro L, Di Marzo V, Prospero-Garcia O. 2007. Pharmacological enhancement of the endocannabinoid system in the nucleus accumbens shell stimulates food intake and increases c-Fos expression in the hypothalamus. Br J Pharmacol 151: 1109-1116.
28. van der Stelt M, Mazzola C, Esposito G, Matias I, Petrosino S, Filippis DD, Micale V, Steardo L, Drago F, Iuvone T. 2006. Endocannabinoids and -amyloid-induced neurotoxicity in vivo: Effect of pharmacological elevation of endocannabinoid levels. Cell Mol Life Sci 63: 1410-1424.
29. van der Stelt M, Trevisani M, Vellani V, De Petrocellis L, Schiano Moriello A, Campi B, McNaughton P, Geppetti P, Di Marzo V. 2005. Anandamide acts as an intracellular messenger amplifying Ca2+ influx via TRPV1 channels. EMBO J 24: 3026-3037.
30. Vandevoorde S, Fowler CJ. 2005. Inhibition of fatty acid amide hydrolase and monoacylglycerol lipase by the anandamide uptake inhibitor VDM11: Evidence that VDM11 acts as an FAAH substrate. Br J Pharmacol 145: 885-893.
31. Vlachou S, Nomikos GG, Panagis G. 2006. Effects of endocannabinoid neurotransmission modulators on brain stimulation reward. Psychopharmacology (Berl) 188: 293-305.
32. Vries TJD, Schoffelmeer ANM. 2005. Cannabinoid CB1 receptors control conditioned drug seeking. Trends Pharmacol Sci 26: 420-426.
33. Wakley AA, Rasmussen EB. 2009. Effects of cannabinoid drugs on the reinforcing properties of food in gestationally undernourished rats. Pharmacol Biochem Behav 94: 30-36.