The role of the ERK1/2 pathway as an alternative to the aging-diminished cyclic AMP pathway in calcitonin-mediated chondrogenesis in human nucleus pulposus

Biomaterials

Volumn 33, Issue 33, 2012, Pages 8256-8264

  Chen, Wei Hong ^a   Zeng, Rong ^b   Lo, Wen Cheng ^c,d   Tina Chen, Szu Yu ^a,e   Lai, Tung Yuan ^a,f   Williams, David F ^a,g   Deng, Win Ping ^a  

^a TAIPEI MEDICAL UNIVERSITY   (Taiwan)

^b GUANGDONG MEDICAL UNIVERSITY   (China)

^c TAIPEI MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

^d TAIPEI MEDICAL UNIVERSITY   (Taiwan)

^e Department of Obstetrics Gynecology   (United States)

^f TAIPEI MEDICAL UNIVERSITY   (Taiwan)

^g WAKE FOREST SCHOOL OF MEDICINE   (United States)

Author keywords

Calcitonin; Disc degeneration; Disc regeneration; ERK1 2; Nucleus pulposus

Indexed keywords

CALCITONIN; DISC DEGENERATION; DISC REGENERATION; ERK1/2; NUCLEUS PULPOSUS;

CELLS; CYTOLOGY; PHOSPHORYLATION; STATISTICAL MECHANICS;

CARTILAGE;

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; CALCITONIN; CALCITONIN RECEPTOR; CYCLIC AMP; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3;

ADULT; AGE DISTRIBUTION; AGED; AGING; ARTICLE; CELL VIABILITY; CHONDROGENESIS; CONTROLLED STUDY; ENZYME INDUCTION; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; FEMALE; GENE EXPRESSION; HUMAN; HUMAN CELL; HUMAN TISSUE; HYPERTROPHY; INTERVERTEBRAL DISK DEGENERATION; MALE; NUCLEUS PULPOSUS; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; SIGNAL TRANSDUCTION; TISSUE REGENERATION;

ADULT; AGED; AGING; CALCITONIN; CELLS, CULTURED; CHONDROGENESIS; CYCLIC AMP; FEMALE; HUMANS; IMMUNOBLOTTING; INTERVERTEBRAL DISC; MALE; MAP KINASE SIGNALING SYSTEM; MIDDLE AGED; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION;

EID: 84866148950     PISSN: 01429612     EISSN: 18785905     Source Type: Journal    
DOI: 10.1016/j.biomaterials.2012.06.088     Document Type: Article

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