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Volumn 2, Issue , 2012, Pages

Reversal of aberrant cancer methylome and transcriptome upon direct reprogramming of lung cancer cells

Author keywords

[No Author keywords available]

Indexed keywords

CARCINOGEN; TRANSCRIPTOME; TUMOR MARKER;

EID: 84866118030     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/srep00592     Document Type: Article
Times cited : (37)

References (56)
  • 1
    • 79952232216 scopus 로고    scopus 로고
    • Global cancer statistics
    • Jemal, A. et al. Global cancer statistics. CA Cancer J Clin 61, 69-90 (2011).
    • (2011) CA Cancer J Clin , vol.61 , pp. 69-90
    • Jemal, A.1
  • 2
    • 1842611683 scopus 로고    scopus 로고
    • Aneuploidy, the primary cause of the multilateral genomic instability of neoplastic and preneoplastic cells
    • DOI 10.1080/15216540410001667902
    • Duesberg, P., Fabarius, A. & Hehlmann, R. Aneuploidy, the primary cause of the multilateral genomic instability of neoplastic and preneoplastic cells. IUBMB Life 56, 65-81 (2004). (Pubitemid 38418923)
    • (2004) IUBMB Life , vol.56 , Issue.2 , pp. 65-81
    • Duesberg, P.1    Fabarius, A.2    Hehlmann, R.3
  • 3
    • 34547792388 scopus 로고    scopus 로고
    • Epigenetic gene silencing in cancer: The DNA hypermethylome
    • DOI 10.1093/hmg/ddm018, Cancer Genetics
    • Esteller, M. Epigenetic gene silencing in cancer: the DNA hypermethylome. Hum Mol Genet 16 Spec No 1, R50-59 (2007). (Pubitemid 47241842)
    • (2007) Human Molecular Genetics , vol.16 , Issue.R1
    • Esteller, M.1
  • 4
    • 0035908493 scopus 로고    scopus 로고
    • Blocking oncogenic Ras signaling for cancer therapy
    • Adjei, A. A. Blocking oncogenic Ras signaling for cancer therapy. J Natl Cancer Inst 93, 1062-1074 (2001). (Pubitemid 32717538)
    • (2001) Journal of the National Cancer Institute , vol.93 , Issue.14 , pp. 1062-1074
    • Adjei, A.A.1
  • 5
    • 0034614637 scopus 로고    scopus 로고
    • The hallmarks of cancer
    • Hanahan, D. & Weinberg, R. A. The hallmarks of cancer. Cell 100, 57-70 (2000). (Pubitemid 30046295)
    • (2000) Cell , vol.100 , Issue.1 , pp. 57-70
    • Hanahan, D.1    Weinberg, R.A.2
  • 6
    • 74049135504 scopus 로고    scopus 로고
    • Concerning the origin of malignant tumours by theodor boveri. Translated and annotated by henry harris
    • Boveri, T. Concerning the origin of malignant tumours by Theodor Boveri. Translated and annotated by Henry Harris. J Cell Sci 121 Suppl 1, 1-84 (2008).
    • (2008) J Cell Sci , vol.121 SUPPL. 1 , pp. 1-84
    • Boveri, T.1
  • 9
    • 36248966518 scopus 로고    scopus 로고
    • Induction of pluripotent stem cells from adult human fibroblasts by defined factors
    • DOI 10.1016/j.cell.2007.11.019, PII S0092867407014717
    • Takahashi, K. et al. Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell 131, 861-872 (2007). (Pubitemid 350138099)
    • (2007) Cell , vol.131 , Issue.5 , pp. 861-872
    • Takahashi, K.1    Tanabe, K.2    Ohnuki, M.3    Narita, M.4    Ichisaka, T.5    Tomoda, K.6    Yamanaka, S.7
  • 10
    • 36749043230 scopus 로고    scopus 로고
    • Induced pluripotent stem cell lines derived from human somatic cells
    • Yu, J. et al. Induced pluripotent stem cell lines derived from human somatic cells. Science 318, 1917-1920 (2007).
    • (2007) Science , vol.318 , pp. 1917-1920
    • Yu, J.1
  • 11
    • 69249208658 scopus 로고    scopus 로고
    • Pluripotent stem cells and disease modeling
    • Colman, A. & Dreesen, O. Pluripotent stem cells and disease modeling. Cell Stem Cell 5, 244-247 (2009).
    • (2009) Cell Stem Cell , vol.5 , pp. 244-247
    • Colman, A.1    Dreesen, O.2
  • 12
    • 80052419902 scopus 로고    scopus 로고
    • Parkinson's disease induced pluripotent stem cells with triplication of the alpha-synuclein locus
    • Devine, M. J. et al. Parkinson's disease induced pluripotent stem cells with triplication of the alpha-synuclein locus. Nat Commun 2, 440 (2011).
    • (2011) Nat Commun , vol.2 , pp. 440
    • Devine, M.J.1
  • 13
    • 78651280899 scopus 로고    scopus 로고
    • Epigenetic reprogramming of breast cancer cells with oocyte extracts
    • Allegrucci, C. et al. Epigenetic reprogramming of breast cancer cells with oocyte extracts. Mol Cancer 10, 7 (2011).
    • (2011) Mol Cancer , vol.10 , pp. 7
    • Allegrucci, C.1
  • 14
    • 76249133692 scopus 로고    scopus 로고
    • Defined factors induce reprogramming of gastrointestinal cancer cells
    • Miyoshi, N. et al. Defined factors induce reprogramming of gastrointestinal cancer cells. Proc Natl Acad Sci U S A 107, 40-45 (2010).
    • (2010) Proc Natl Acad Sci U S A , vol.107 , pp. 40-45
    • Miyoshi, N.1
  • 15
    • 70350380887 scopus 로고    scopus 로고
    • Sox2 is dispensable for the reprogramming of melanocytes and melanoma cells into induced pluripotent stem cells
    • Utikal, J., Maherali, N., Kulalert, W. & Hochedlinger, K. Sox2 is dispensable for the reprogramming of melanocytes and melanoma cells into induced pluripotent stem cells. J Cell Sci 122, 3502-3510 (2009).
    • (2009) J Cell Sci , vol.122 , pp. 3502-3510
    • Utikal, J.1    Maherali, N.2    Kulalert, W.3    Hochedlinger, K.4
  • 16
    • 78650752402 scopus 로고    scopus 로고
    • Cell type of origin influences the molecular and functional properties of mouse induced pluripotent stem cells
    • Polo, J. M. et al. Cell type of origin influences the molecular and functional properties of mouse induced pluripotent stem cells. Nat Biotechnol 28, 848-855 (2010).
    • (2010) Nat Biotechnol , vol.28 , pp. 848-855
    • Polo, J.M.1
  • 17
    • 67649222358 scopus 로고    scopus 로고
    • Induced pluripotent stem cells and embryonic stem cells are distinguished by gene expression signatures
    • Chin, M. H. et al. Induced pluripotent stem cells and embryonic stem cells are distinguished by gene expression signatures. Cell Stem Cell 5, 111-123 (2009).
    • (2009) Cell Stem Cell , vol.5 , pp. 111-123
    • Chin, M.H.1
  • 18
    • 79551677421 scopus 로고    scopus 로고
    • Reference Maps of human ES and iPS cell variation enable highthroughput characterization of pluripotent cell lines
    • Bock, C. et al. Reference Maps of human ES and iPS cell variation enable highthroughput characterization of pluripotent cell lines. Cell 144, 439-452 (2011).
    • (2011) Cell , vol.144 , pp. 439-452
    • Bock, C.1
  • 19
    • 79956330964 scopus 로고    scopus 로고
    • CpG islands and the regulation of transcription
    • Deaton, A. M. & Bird, A. CpG islands and the regulation of transcription. Genes Dev 25, 1010-1022 (2011).
    • (2011) Genes Dev , vol.25 , pp. 1010-1022
    • Deaton, A.M.1    Bird, A.2
  • 20
    • 51649129596 scopus 로고    scopus 로고
    • Lineage-specific polycomb targets and de novo DNA methylation define restriction and potential of neuronal progenitors
    • Mohn, F. et al. Lineage-specific polycomb targets and de novo DNA methylation define restriction and potential of neuronal progenitors. Mol Cell 30, 755-766 (2008).
    • (2008) Mol Cell , vol.30 , pp. 755-766
    • Mohn, F.1
  • 22
    • 77956418156 scopus 로고    scopus 로고
    • Gene expression-based classification of non-small cell lung carcinomas and survival prediction
    • Hou, J. et al. Gene expression-based classification of non-small cell lung carcinomas and survival prediction. PLoS One 5, e10312 (2010).
    • (2010) PLoS One , vol.5
    • Hou, J.1
  • 24
    • 83255187667 scopus 로고    scopus 로고
    • S100P: A novel therapeutic target for cancer
    • Arumugam, T. & Logsdon, C. D. S100P: a novel therapeutic target for cancer. Amino Acids 41, 893-899 (2011).
    • (2011) Amino Acids , vol.41 , pp. 893-899
    • Arumugam, T.1    Logsdon, C.D.2
  • 25
    • 58149492132 scopus 로고    scopus 로고
    • Genomics screen in transformed stem cells reveals RNASEH2A, PPAP2C, and ADARB1 as putative anticancer drug targets
    • Flanagan, J. M. et al. Genomics screen in transformed stem cells reveals RNASEH2A, PPAP2C, and ADARB1 as putative anticancer drug targets. Mol Cancer Ther 8, 249-260 (2009).
    • (2009) Mol Cancer Ther , vol.8 , pp. 249-260
    • Flanagan, J.M.1
  • 26
    • 0037168127 scopus 로고    scopus 로고
    • Novel candidate tumor marker genes for lung adenocarcinoma
    • Wang, K. K. et al. Novel candidate tumor marker genes for lung adenocarcinoma. Oncogene 21, 7598-7604 (2002).
    • (2002) Oncogene , vol.21 , pp. 7598-7604
    • Wang, K.K.1
  • 27
    • 33646122426 scopus 로고    scopus 로고
    • Expression of p63, keratin 5/6, keratin 7, and surfactant-A in non-small cell lung carcinomas
    • Camilo, R., Capelozzi, V. L., Siqueira, S. A. & Del Carlo Bernardi, F. Expression of p63, keratin 5/6, keratin 7, and surfactant-A in non-small cell lung carcinomas. Hum Pathol 37, 542-546 (2006).
    • (2006) Hum Pathol , vol.37 , pp. 542-546
    • Camilo, R.1    Capelozzi, V.L.2    Siqueira, S.A.3    Del Carlo, B.F.4
  • 28
    • 33846115005 scopus 로고    scopus 로고
    • CancerGenes: A gene selection resource for cancer genome projects
    • DOI 10.1093/nar/gkl811
    • Higgins, M. E., Claremont, M.,Major, J. E., Sander, C. & Lash, A. E. CancerGenes: a gene selection resource for cancer genome projects. Nucleic Acids Res 35, D721-726 (2007). (Pubitemid 46056298)
    • (2007) Nucleic Acids Research , vol.35 , Issue.SUPPL. 1
    • Higgins, M.E.1    Claremont, M.2    Major, J.E.3    Sander, C.4    Lash, A.E.5
  • 29
    • 60549114349 scopus 로고    scopus 로고
    • The proangiogenic factor ephrin-A1 is up-regulated in radioresistant murine tumor by irradiation
    • Nojiri, K. et al. The proangiogenic factor ephrin-A1 is up-regulated in radioresistant murine tumor by irradiation. Exp Biol Med (Maywood) 234, 112-122 (2009).
    • (2009) Exp Biol Med (Maywood) , vol.234 , pp. 112-122
    • Nojiri, K.1
  • 30
    • 77957335239 scopus 로고    scopus 로고
    • Hypoxia increases HIF-1alpha expression and constitutive cytokine release by primary human acute myeloid leukaemia cells
    • Hatfield, K. J., Bedringsaas, S. L., Ryningen, A., Gjertsen, B. T. & Bruserud, O. Hypoxia increases HIF-1alpha expression and constitutive cytokine release by primary human acute myeloid leukaemia cells. Eur Cytokine Netw 21, 154-164 (2010).
    • (2010) Eur Cytokine Netw , vol.21 , pp. 154-164
    • Hatfield, K.J.1    Bedringsaas, S.L.2    Ryningen, A.3    Gjertsen, B.T.4    Bruserud, O.5
  • 31
    • 77954642877 scopus 로고    scopus 로고
    • CXC chemokines in cancer angiogenesis and metastases
    • Keeley, E. C.,Mehrad, B. & Strieter, R. M. CXC chemokines in cancer angiogenesis and metastases. Adv Cancer Res 106, 91-111 (2010).
    • (2010) Adv Cancer Res , vol.106 , pp. 91-111
    • Keeley, E.C.1    Mehrad, B.2    Strieter, R.M.3
  • 32
    • 79957666856 scopus 로고    scopus 로고
    • Id1 promotes lung cancer cell proliferation and tumor growth through Akt-related pathway
    • Cheng, Y. J. et al. Id1 promotes lung cancer cell proliferation and tumor growth through Akt-related pathway. Cancer Lett 307, 191-199 (2011).
    • (2011) Cancer Lett , vol.307 , pp. 191-199
    • Cheng, Y.J.1
  • 34
    • 80054789932 scopus 로고    scopus 로고
    • Tumor suppressor gene ZAC/PLAGL1: Altered expression and loss of the nonimprinted allele in pheochromocytomas
    • Jarmalaite, S. et al. Tumor suppressor gene ZAC/PLAGL1: altered expression and loss of the nonimprinted allele in pheochromocytomas. Cancer Genet 204, 398-404 (2011).
    • (2011) Cancer Genet , vol.204 , pp. 398-404
    • Jarmalaite, S.1
  • 35
    • 69349100179 scopus 로고    scopus 로고
    • Suppression of induced pluripotent stem cell generation by the p53-p21 pathway
    • Hong, H. et al. Suppression of induced pluripotent stem cell generation by the p53-p21 pathway. Nature 460, 1132-1135 (2009).
    • (2009) Nature , vol.460 , pp. 1132-1135
    • Hong, H.1
  • 37
    • 52949125268 scopus 로고    scopus 로고
    • Mir-302 reprograms human skin cancer cells into a pluripotent EScell- like state
    • Lin, S. L. et al.Mir-302 reprograms human skin cancer cells into a pluripotent EScell- like state. RNA 14, 2115-2124 (2008).
    • (2008) RNA , vol.14 , pp. 2115-2124
    • Lin, S.L.1
  • 38
    • 77953250105 scopus 로고    scopus 로고
    • Generation of iPSCs from cultured human malignant cells
    • Carette, J. E. et al. Generation of iPSCs from cultured human malignant cells. Blood 115, 4039-4042 (2010).
    • (2010) Blood , vol.115 , pp. 4039-4042
    • Carette, J.E.1
  • 39
    • 79959908506 scopus 로고    scopus 로고
    • HIF induces human embryonic stem cell markers in cancer cells
    • Mathieu, J. et al. HIF induces human embryonic stem cell markers in cancer cells. Cancer Res 71, 4640-4652 (2011).
    • (2011) Cancer Res , vol.71 , pp. 4640-4652
    • Mathieu, J.1
  • 40
    • 77955777216 scopus 로고    scopus 로고
    • Aberrant epigenetic silencing of tumor suppressor genes is reversed by direct reprogramming
    • Ron-Bigger, S. et al. Aberrant epigenetic silencing of tumor suppressor genes is reversed by direct reprogramming. Stem Cells 28, 1349-1354 (2010).
    • (2010) Stem Cells , vol.28 , pp. 1349-1354
    • Ron-Bigger, S.1
  • 41
    • 84857785696 scopus 로고    scopus 로고
    • DNAhypermethylation in lung cancer is targeted at differentiation- associated genes
    • Helman, E., Naxerova, K. & Kohane, I. S.DNAhypermethylation in lung cancer is targeted at differentiation-associated genes. Oncogene 31, 1181-1188 (2012).
    • (2012) Oncogene , vol.31 , pp. 1181-1188
    • Helman, E.1    Naxerova, K.2    Kohane, I.S.3
  • 42
    • 33746428637 scopus 로고    scopus 로고
    • Predicting survival within the lung cancer histopathological hierarchy using a multi-scale genomic model of development
    • Liu, H., Kho, A. T., Kohane, I. S. & Sun, Y. Predicting survival within the lung cancer histopathological hierarchy using a multi-scale genomic model of development. PLoS Med 3, e232 (2006).
    • (2006) PLoS Med , vol.3
    • Liu, H.1    Kho, A.T.2    Kohane, I.S.3    Sun, Y.4
  • 43
    • 48549094872 scopus 로고    scopus 로고
    • Analysis of gene expression in a developmental context emphasizes distinct biological leitmotifs in human cancers
    • Naxerova, K. et al. Analysis of gene expression in a developmental context emphasizes distinct biological leitmotifs in human cancers. Genome Biol 9, R108 (2008).
    • (2008) Genome Biol , vol.9
    • Naxerova, K.1
  • 44
    • 45749140422 scopus 로고    scopus 로고
    • Gene expression signature of cigarette smoking and its role in lung adenocarcinoma development and survival
    • Landi, M. T. et al. Gene expression signature of cigarette smoking and its role in lung adenocarcinoma development and survival. PLoS One 3, e1651 (2008).
    • (2008) PLoS One , vol.3
    • Landi, M.T.1
  • 46
    • 0038040768 scopus 로고    scopus 로고
    • Matrix metalloproteinase inhibitors for cancer therapy: The current situation and future prospects
    • DOI 10.1517/14728222.7.3.385
    • Fingleton, B. Matrix metalloproteinase inhibitors for cancer therapy:the current situation and future prospects. Expert Opin Ther Targets 7, 385-397 (2003). (Pubitemid 36722223)
    • (2003) Expert Opinion on Therapeutic Targets , vol.7 , Issue.3 , pp. 385-397
    • Fingleton, B.1
  • 47
    • 79959285404 scopus 로고    scopus 로고
    • Stat5: From breast development to cancer prognosis, prediction, and progression
    • Tweardy, D. & Chang, J. C. Stat5: from breast development to cancer prognosis, prediction, and progression. J Clin Oncol 29, 2443-2444 (2011).
    • (2011) J Clin Oncol , vol.29 , pp. 2443-2444
    • Tweardy, D.1    Chang, J.C.2
  • 49
    • 33644856123 scopus 로고    scopus 로고
    • Epigenetic therapy of cancer: Past, present and future
    • Yoo, C. B.& Jones, P.A. Epigenetic therapy of cancer: past, present and future. Nat Rev Drug Discov 5, 37-50 (2006).
    • (2006) Nat Rev Drug Discov , vol.5 , pp. 37-50
    • Yoo, C.B.1    Jones, P.A.2
  • 50
    • 46249088370 scopus 로고    scopus 로고
    • Lumi: A pipeline for processing Illumina microarray
    • DOI 10.1093/bioinformatics/btn224
    • Du, P., Kibbe, W. A. & Lin, S. M. lumi: a pipeline for processing Illumina microarray. Bioinformatics 24, 1547-1548 (2008). (Pubitemid 351911712)
    • (2008) Bioinformatics , vol.24 , Issue.13 , pp. 1547-1548
    • Du, P.1    Kibbe, W.A.2    Lin, S.M.3
  • 51
    • 4544341015 scopus 로고    scopus 로고
    • Linear models and empirical bayes methods for assessing differential expression in microarray experiments
    • Article3
    • Smyth, G. K. Linear models and empirical bayes methods for assessing differential expression in microarray experiments. Stat Appl Genet Mol Biol 3,Article3 (2004).
    • (2004) Stat Appl Genet Mol Biol , vol.3
    • Smyth, G.K.1
  • 52
    • 84858341887 scopus 로고    scopus 로고
    • Team R. d. c. R: A language and environment for statistical computing
    • team, R. d. c. R: A language and environment for statistical computing. R foundation for statistical computing. (2011).
    • (2011) R Foundation for Statistical Computing
  • 53
    • 0037316303 scopus 로고    scopus 로고
    • A comparison of normalization methods for high density oligonucleotide array data based on variance and bias
    • DOI 10.1093/bioinformatics/19.2.185
    • Bolstad, B. M., Irizarry, R. A., Astrand, M. & Speed, T. P. A comparison of normalization methods for high density oligonucleotide array data based on variance and bias. Bioinformatics 19, 185-193 (2003). (Pubitemid 36181903)
    • (2003) Bioinformatics , vol.19 , Issue.2 , pp. 185-193
    • Bolstad, B.M.1    Irizarry, R.A.2    Astrand, M.3    Speed, T.P.4
  • 54
    • 78649475003 scopus 로고    scopus 로고
    • Comparison of Beta-value and M-value methods for quantifying methylation levels by microarray analysis
    • Du, P. et al. Comparison of Beta-value and M-value methods for quantifying methylation levels by microarray analysis. BMC Bioinformatics 11, 587 (2010).
    • (2010) BMC Bioinformatics , vol.11 , pp. 587
    • Du, P.1
  • 55
    • 58549112996 scopus 로고    scopus 로고
    • Bioinformatics enrichment tools: Paths toward the comprehensive functional analysis of large gene lists
    • Huang da, W., Sherman, B. T. & Lempicki, R. A. Bioinformatics enrichment tools: paths toward the comprehensive functional analysis of large gene lists. Nucleic Acids Res 37, 1-13 (2009).
    • (2009) Nucleic Acids Res , vol.37 , pp. 1-13
    • Huang Da, W.1    Sherman, B.T.2    Lempicki, R.A.3
  • 56
    • 61449172037 scopus 로고    scopus 로고
    • Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources
    • Huang da, W., Sherman, B. T. & Lempicki, R. A. Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources. Nat Protoc 4, 44-57 (2009).
    • (2009) Nat Protoc , vol.4 , pp. 44-57
    • Huang Da, W.1    Sherman, B.T.2    Lempicki, R.A.3


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