ANIMAL TISSUE;
ARTICLE;
CARBON NUCLEAR MAGNETIC RESONANCE;
CHEMICAL REACTION;
CHEMICAL STRUCTURE;
CONTROLLED STUDY;
DRUG ISOLATION;
DRUG SYNTHESIS;
EXPERIMENTAL RABBIT;
INFRARED SPECTROSCOPY;
MASS SPECTROMETRY;
NONHUMAN;
PROTON NUCLEAR MAGNETIC RESONANCE;
SMOOTH MUSCLE RELAXATION;
STOMACH FUNDUS;
Vasorelaxing properties of some phenylacridine type potassium channel openers in isolated rabbit thoracic arteries
Berkan O, Saraç B, Simsek R, Yildirim S, Sarioǧlu Y, Safak C (2002) Vasorelaxing properties of some phenylacridine type potassium channel openers in isolated rabbit thoracic arteries. Eur J Med Chem 7:519-523
Pharmaceutical 1,4,5,6,7,8-hexahydro-5-oxoquinolines and 1,2,3,4,5,6,7,8,9,10-decahydro-1,8-dioxoacridines
Bossert F, Vater W (1971) Pharmaceutical 1,4,5,6,7,8-hexahydro-5- oxoquinolines and 1,2,3,4,5,6,7,8,9,10-decahydro-1,8-dioxoacridines, Ger Offen 2,003,148 (Cl. C07 d), ref. C. A.: 75: 98459c
Synthesis and structure-activity relationships of a novel series of tricyclic dihydropyridine-based KATP openers that potently inhibit bladder contractions in vitro
Carroll WA, Agrios KA, Altenbach RJ, Buckner SA, Chen Y, Coghlan MJ et al (2004a) Synthesis and structure-activity relationships of a novel series of tricyclic dihydropyridine-based KATP openers that potently inhibit bladder contractions in vitro. J Med Chem 47(12):3180-3192
Synthesis and structure-activity relationships of a novel series of 2,3,5,6,7,9-hexahydrothieno[3,2-b]quinolin-8(4H)-one 1,1-dioxide K(ATP) channel openers: Discovery of (-)-(9S)-9-(3-bromo-4-fluorophenyl)-2,3,5,6,7,9- hexahydrothieno [3,2-b]quinolin-8(4H)-one 1,1-dioxide (A-278637), a potent K(ATP) opener that selectively inhibits spontaneous bladder contractions
Carroll WA, Altenbach RJ, Bai H, Brioni JD, Brune ME, Buckner SA et al (2004b) Synthesis and structure-activity relationships of a novel series of 2,3,5,6,7,9-hexahydrothieno[3,2-b]quinolin-8(4H)-one 1,1-dioxide K(ATP) channel openers: discovery of (-)-(9S)-9-(3-bromo-4-fluorophenyl)-2,3,5,6,7,9- hexahydrothieno [3,2-b]quinolin-8(4H)-one 1,1-dioxide (A-278637), a potent K(ATP) opener that selectively inhibits spontaneous bladder contractions. J Med Chem 47:3163-3179
Pharmacology and modulation of K(ATP) channels by protein kinase C and phosphatases in gallbladder smooth muscle
Firth TA, Mawe GM, Nelson MT (2000) Pharmacology and modulation of K(ATP) channels by protein kinase C and phosphatases in gallbladder smooth muscle. Am J Physiol Cell Physiol 278:1031-1037
Pharmacological characterization of a 1,4-dihydropyridine analogue, 9-(3,4-dichlorophenyl)-3,3,6,6-tetramethyl-3,4,6,7,9,10-hexahydro-1,8(2H,5H) -acridinedione (A-184209) as a novel K(ATP) channel inhibitor
Gopalakrishnan M, Miller TR, Buckner SA, Milicic I, Molinari EJ, Whiteaker KL (2003) Pharmacological characterization of a 1,4-dihydropyridine analogue, 9-(3,4-dichlorophenyl)-3,3,6,6-tetramethyl-3,4,6,7,9,10-hexahydro-1, 8(2H,5H)-acridinedione (A-184209) as a novel K(ATP) channel inhibitor. Br J Pharmacol 138(2):393-399
Substituted 9-aryl-1,8-acridinedione derivatives and their effects on potassium channels
Gündüz MG, Doǧan AE, Simsek R, Erol K, Safak C (2009) Substituted 9-aryl-1,8-acridinedione derivatives and their effects on potassium channels. Med Chem Res 18(4):317-325
Pharmacological modulation of calcium and potassium channels in isolated vascular smooth muscle cells
Kläckner U, Trieschmann U (1989) Pharmacological modulation of calcium and potassium channels in isolated vascular smooth muscle cells. Arzneim Forsch Drug Res 39:120-126
Voltage-activated potassium channels in mammalian neurons and their block by novel pharmacological agents
Mathie A, Wooltorton JR, Watkins CS (1998) Voltage-activated potassium channels in mammalian neurons and their block by novel pharmacological agents. Gen Pharmacol 30(1):13-24
Role of K+ channels in M2 muscarinic receptor-mediated inhibition of noradrenaline release from the rat stomach
Nakamura K, Okada S, Yamaguchi N, Shimizu T, Yokotani K (2004) Role of K+ channels in M2 muscarinic receptor-mediated inhibition of noradrenaline release from the rat stomach. J Pharmacol Sci 96(3):286-292
Synthesis of 2-methyl-4-aryl-4,6,7,8-tetrahydro-5(1H)-quinolone derivatives and their effects on potassium channels
Özturk GS, Vural M, Gunduz MG, Simsek R, Sarioǧlu Y, Safak C (2008) Synthesis of 2-methyl-4-aryl-4,6,7,8-tetrahydro-5(1H)-quinolone derivatives and their effects on potassium channels. Arzneim Forsch Drug Res 58(1):659-665
Potassium Channel opening activities of some acridine derivatives
Saraç B, Aydin C, Simsek R, Yildirim MK, Koyuncu A, Safak C (2002) Potassium Channel opening activities of some acridine derivatives. J Hac Univ Fac Pharm 22:49-55
ATP-sensitive K(?) channels composed of Kir6.1 and SUR2B subunits in guinea pig gastric myocytes
Sim JH, Yang DK, Kim YC, Park SJ, Kang TM, So I et al (2002) ATP-sensitive K(?) channels composed of Kir6.1 and SUR2B subunits in guinea pig gastric myocytes. Am J Physiol Gastrointest Liver Physiol 282(1):137-142
Some arylacridine derivatives possessing potassium channel opening activity
Simsek R, Özkan M, Kismetli E, Uma S, Safak C (2004) Some arylacridine derivatives possessing potassium channel opening activity. Il Farmaco 59:939-943
Regulation of adrenergic nerve-mediated contraction of canine pulmonary artery by K+ channels
Tagaya E, Tamaoki J, Takemura H, Nagai A (1998) Regulation of adrenergic nerve-mediated contraction of canine pulmonary artery by K+ channels. Eur Respir J 11(3):571-574
