Beyond nutrition: Health-promoting foods by quorum-sensing inhibition

Future Microbiology

Volumn 7, Issue 9, 2012, Pages 1025-1028

  Givskov, Michael ^a,b  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b NANYANG TECHNOLOGICAL UNIVERSITY   (Singapore)

Author keywords

biofilm dispersal; biofilms; c di GMP; functional food; garlic; herbs; immune system; natural compounds; quorum sensing

Indexed keywords

DIET; FOOD; FOOD INTAKE; HEALTH PROMOTION; HUMAN; INFECTION RESISTANCE; INFECTION SENSITIVITY; NUTRITION; PRIORITY JOURNAL; QUORUM SENSING; REVIEW;

ANIMALS; ANTI-BACTERIAL AGENTS; ARMORACIA; BACTERIA; BACTERIAL INFECTIONS; BIOFILMS; GARLIC; GENE EXPRESSION REGULATION, BACTERIAL; HUMANS; MICE; PLANT EXTRACTS; QUORUM SENSING;

ALLIUM SATIVUM;

EID: 84866084166     PISSN: 17460913     EISSN: 17460921     Source Type: Journal    
DOI: 10.2217/fmb.12.84     Document Type: Review

References (11)

1. Bjarnsholt T, van Gennip M, Jakobsen TH, Christensen LD, Jensen PO, Givskov M. In vitro screens for quorum sensing inhibitors and in vivo confirmation of their effect. Nat. Protoc. 5(2), 282-293 (2010).
2. Hentzer M, Wu H, Andersen JB et al. Attenuation of Pseudomonas aeruginosa virulence by quorum sensing inhibitors. EMBO J. 22(15), 3803-3815 (2003).
3. Jensen PØ, Bjarnsholt T, Phipps R et al. Rapid necrotic killing of polymorphonuclear leukocytes is caused by quorum-sensing-controlled production of rhamnolipid by Pseudomonas aeruginosa. Microbiology 153(Pt 5), 1329-1338 (2007).
4. Gjermansen M, Ragas P, Sternberg C, Molin S, Tolker-Nielsen T. Characterization of starvation-induced dispersion in Pseudomonas putida biofilms. Environ. Microbiol. 7(6), 894-906 (2005).
5. Gjermansen M, Ragas P, Tolker-Nielsen T. Proteins with GGDEF and EAL domains regulate Pseudomonas putida biofilm formation and dispersal. FEMS Microbiol. Lett. 265(2), 215-224 (2006).
6. Block E. Garlic and Other Alliums: THE Lore and the Science Publisher. Royal Society of Chemistry, Cambridge, UK (2010).
7. Bjarnsholt T, Jensen PØ, Rasmussen TB et al. Garlic which blocks the Pseudomonas aeruginosa communication systems, promotes rapid clearing of pulmonary Pseudomonas aeruginosa infections. Microbiology 151(Pt 12), 3873-3880 (2005).
8. Jakobsen TH, van Gennip M, Phipps RK et al. Ajoene, a sulfur-rich molecule from garlic, inhibits genes controlled by quorum sensing. Antimicrob. Agents Chemother. 56(5), 2314-2325 (2012).
9. Jakobsen TH, Bragason SK, Phipps RK et al. Food as a source for quorum sensing inhibitors: Iberin from horseradish revealed as a quorum sensing inhibitor of Pseudomonas aeruginosa. Appl. Environ. Microbiol. 78(7), 2410-2421 (2012).
10. Christensen LD, van Gennip M, Jakobsen TH et al. Synergistic antibacterial efficacy of early combination treatment with tobramycin and quorum-sensing inhibitors against Pseudomonas aeruginosa in an intraperitoneal foreign-body infection mouse model. J. Antimicrob. Chemother. 67(5), 1198-1206 (2012).
11. Givskov M, de Nys R, Manefield M et al. Eukaryotic interference with homoserine lactone mediated prokaryotic signalling. J. Bacteriol. 178, 6618-6622 (1996).