-
1
-
-
84969213492
-
Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls
-
WTCCC
-
WTCCC (2007) Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. Nature 447: 661-678 doi:10.1038/nature05911.
-
(2007)
Nature
, vol.447
, pp. 661-678
-
-
-
2
-
-
0029741063
-
The future of genetic studies of complex human diseases
-
Risch N, Merikangas K, (1996) The future of genetic studies of complex human diseases. Science 273: 1516-1517.
-
(1996)
Science
, vol.273
, pp. 1516-1517
-
-
Risch, N.1
Merikangas, K.2
-
3
-
-
0034660559
-
Searching for genetic determinants in the new millennium
-
Risch N, (2000) Searching for genetic determinants in the new millennium. Nature 405: 847-856 doi:10.1038/35015718.
-
(2000)
Nature
, vol.405
, pp. 847-856
-
-
Risch, N.1
-
4
-
-
84855510023
-
What is complex about complex disorders?
-
Mitchell KJ, (2012) What is complex about complex disorders? Genome Biology 13: 237 doi:10.1186/gb-2012-13-1-237.
-
(2012)
Genome Biology
, vol.13
, pp. 237
-
-
Mitchell, K.J.1
-
5
-
-
77957875452
-
A general model for multilocus epistatic interactions in case-control studies
-
Wang Z, Liu T, Lin Z, Hegarty J, Koltun WA, et al. (2010) A general model for multilocus epistatic interactions in case-control studies. PLoS ONE 5: e11384 doi:10.1371/journal.pone.0011384.
-
(2010)
PLoS ONE
, vol.5
-
-
Wang, Z.1
Liu, T.2
Lin, Z.3
Hegarty, J.4
Koltun, W.A.5
-
6
-
-
58549096683
-
Decanalization and the origin of complex disease
-
Gibson G, (2009) Decanalization and the origin of complex disease. Nat Rev Genet 10: 134-140 doi:10.1038/nrg2502.
-
(2009)
Nat Rev Genet
, vol.10
, pp. 134-140
-
-
Gibson, G.1
-
7
-
-
70349956433
-
Finding the missing heritability of complex diseases
-
Manolio TA, Collins FS, Cox NJ, Goldstein DB, Hindorff LA, et al. (2009) Finding the missing heritability of complex diseases. Nature 461: 747-753 doi:10.1038/nature08494.
-
(2009)
Nature
, vol.461
, pp. 747-753
-
-
Manolio, T.A.1
Collins, F.S.2
Cox, N.J.3
Goldstein, D.B.4
Hindorff, L.A.5
-
8
-
-
0034758045
-
Genomewide Scans of Complex Human Diseases: True Linkage Is Hard to Find
-
Altmüller J, Palmer LJ, Fischer G, Scherb H, Wjst M, (2001) Genomewide Scans of Complex Human Diseases: True Linkage Is Hard to Find. Am J Hum Genet 69: 936-950.
-
(2001)
Am J Hum Genet
, vol.69
, pp. 936-950
-
-
Altmüller, J.1
Palmer, L.J.2
Fischer, G.3
Scherb, H.4
Wjst, M.5
-
9
-
-
57649136554
-
Progress and challenges in genome-wide association studies in humans
-
Donnelly P, (2008) Progress and challenges in genome-wide association studies in humans. Nature 456: 728-731 doi:10.1038/nature07631.
-
(2008)
Nature
, vol.456
, pp. 728-731
-
-
Donnelly, P.1
-
10
-
-
77954891473
-
GWAS: heritability missing in action?
-
Clarke AJ, Cooper DN, (2010) GWAS: heritability missing in action? Eur J Hum Genet 18: 859-861 doi:10.1038/ejhg.2010.35.
-
(2010)
Eur J Hum Genet
, vol.18
, pp. 859-861
-
-
Clarke, A.J.1
Cooper, D.N.2
-
11
-
-
77952888454
-
Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci
-
Stahl EA, Raychaudhuri S, Remmers EF, Xie G, Eyre S, et al. (2010) Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci. Nat Genet 42: 508-514 doi:10.1038/ng.582.
-
(2010)
Nat Genet
, vol.42
, pp. 508-514
-
-
Stahl, E.A.1
Raychaudhuri, S.2
Remmers, E.F.3
Xie, G.4
Eyre, S.5
-
12
-
-
67349199566
-
Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes
-
Barrett JC, Clayton DG, Concannon P, Akolkar B, Cooper JD, et al. (2009) Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes. Nat Genet 41: 703-707 doi:10.1038/ng.381.
-
(2009)
Nat Genet
, vol.41
, pp. 703-707
-
-
Barrett, J.C.1
Clayton, D.G.2
Concannon, P.3
Akolkar, B.4
Cooper, J.D.5
-
13
-
-
68449086236
-
Common polygenic variation contributes to risk of schizophrenia and bipolar disorder
-
Purcell SM, Wray NR, Stone JL, Visscher PM, O'Donovan MC, et al. (2009) Common polygenic variation contributes to risk of schizophrenia and bipolar disorder. Nature 460: 748-752 doi:10.1038/nature08185.
-
(2009)
Nature
, vol.460
, pp. 748-752
-
-
Purcell, S.M.1
Wray, N.R.2
Stone, J.L.3
Visscher, P.M.4
O'Donovan, M.C.5
-
14
-
-
58149357365
-
Genome-wide association studies in cancer
-
Easton DF, Eeles RA, (2008) Genome-wide association studies in cancer. Human Molecular Genetics 17: R109-R115 doi:10.1093/hmg/ddn287.
-
(2008)
Human Molecular Genetics
, vol.17
-
-
Easton, D.F.1
Eeles, R.A.2
-
15
-
-
78649489009
-
Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci
-
Franke A, McGovern DPB, Barrett JC, Wang K, Radford-Smith GL, et al. (2010) Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci. Nat Genet 42: 1118-1125 doi:10.1038/ng.717.
-
(2010)
Nat Genet
, vol.42
, pp. 1118-1125
-
-
Franke, A.1
McGovern, D.P.B.2
Barrett, J.C.3
Wang, K.4
Radford-Smith, G.L.5
-
16
-
-
41149152918
-
Biostatistical aspects of genome-wide association studies
-
Ziegler A, König IR, Thompson JR, (2008) Biostatistical aspects of genome-wide association studies. Biom J 50: 8-28 doi:10.1002/bimj.200710398.
-
(2008)
Biom J
, vol.50
, pp. 8-28
-
-
Ziegler, A.1
König, I.R.2
Thompson, J.R.3
-
17
-
-
84855925920
-
Rare and common variants: twenty arguments
-
Gibson G, (2011) Rare and common variants: twenty arguments. Nat Rev Genet 13: 135-145 doi:10.1038/nrg3118.
-
(2011)
Nat Rev Genet
, vol.13
, pp. 135-145
-
-
Gibson, G.1
-
18
-
-
33847059518
-
Detection of gene × gene interactions in genome-wide association studies of human population data
-
Musani SK, Shriner D, Liu N, Feng R, Coffey CS, et al. (2007) Detection of gene × gene interactions in genome-wide association studies of human population data. Hum Hered 63: 67-84 doi:10.1159/000099179.
-
(2007)
Hum Hered
, vol.63
, pp. 67-84
-
-
Musani, S.K.1
Shriner, D.2
Liu, N.3
Feng, R.4
Coffey, C.S.5
-
19
-
-
77949497074
-
Bioinformatics challenges for genome-wide association studies
-
Moore JH, Asselbergs FW, Williams SM, (2010) Bioinformatics challenges for genome-wide association studies. Bioinformatics 26: 445-455 doi:10.1093/bioinformatics/btp713.
-
(2010)
Bioinformatics
, vol.26
, pp. 445-455
-
-
Moore, J.H.1
Asselbergs, F.W.2
Williams, S.M.3
-
20
-
-
67349166946
-
Detecting gene-gene interactions that underlie human diseases
-
Cordell HJ, (2009) Detecting gene-gene interactions that underlie human diseases. Nat Rev Genet 10: 392-404 doi:10.1038/nrg2579.
-
(2009)
Nat Rev Genet
, vol.10
, pp. 392-404
-
-
Cordell, H.J.1
-
21
-
-
70450223891
-
Common disorders are quantitative traits
-
Plomin R, Haworth CMA, Davis OSP, (2009) Common disorders are quantitative traits. Nat Rev Genet 10: 872-878 doi:10.1038/nrg2670.
-
(2009)
Nat Rev Genet
, vol.10
, pp. 872-878
-
-
Plomin, R.1
Haworth, C.M.A.2
Davis, O.S.P.3
-
22
-
-
77954140531
-
Common SNPs explain a large proportion of the heritability for human height
-
Yang J, Benyamin B, McEvoy BP, Gordon S, Henders AK, et al. (2010) Common SNPs explain a large proportion of the heritability for human height. Nat Genet 42: 565-569 doi:10.1038/ng.608.
-
(2010)
Nat Genet
, vol.42
, pp. 565-569
-
-
Yang, J.1
Benyamin, B.2
McEvoy, B.P.3
Gordon, S.4
Henders, A.K.5
-
23
-
-
84856405512
-
The mystery of missing heritability: Genetic interactions create phantom heritability
-
Zuk O, Hechter E, Sunyaev SR, Lander ES, (2012) The mystery of missing heritability: Genetic interactions create phantom heritability. Proc Natl Acad Sci USA 109: 1193-1198 doi:10.1073/pnas.1119675109.
-
(2012)
Proc Natl Acad Sci USA
, vol.109
, pp. 1193-1198
-
-
Zuk, O.1
Hechter, E.2
Sunyaev, S.R.3
Lander, E.S.4
-
24
-
-
0345411335
-
The ubiquitous nature of epistasis in determining susceptibility to common human diseases
-
Moore JH, (2003) The ubiquitous nature of epistasis in determining susceptibility to common human diseases. Hum Hered 56: 73-82 doi:10.1159/000073735.
-
(2003)
Hum Hered
, vol.56
, pp. 73-82
-
-
Moore, J.H.1
-
25
-
-
77952741514
-
An automated reasoning framework for translational research
-
Riva A, Nuzzo A, Stefanelli M, Bellazzi R, (2010) An automated reasoning framework for translational research. J Biomed Inform 43: 419-427 doi:10.1016/j.jbi.2009.11.005.
-
(2010)
J Biomed Inform
, vol.43
, pp. 419-427
-
-
Riva, A.1
Nuzzo, A.2
Stefanelli, M.3
Bellazzi, R.4
-
26
-
-
46949101742
-
Exploiting the Proteome to Improve the Genome-Wide Genetic Analysis of Epistasis in Common Human Diseases
-
Pattin KA, Moore JH, (2008) Exploiting the Proteome to Improve the Genome-Wide Genetic Analysis of Epistasis in Common Human Diseases. Hum Genet 124: 19-29 doi:10.1007/s00439-008-0522-8.
-
(2008)
Hum Genet
, vol.124
, pp. 19-29
-
-
Pattin, K.A.1
Moore, J.H.2
-
27
-
-
70349991890
-
The SNP ratio test: pathway analysis of genome-wide association datasets
-
O'Dushlaine C, Kenny E, Heron EA, Segurado R, Gill M, et al. (2009) The SNP ratio test: pathway analysis of genome-wide association datasets. Bioinformatics 25: 2762-2763 doi:10.1093/bioinformatics/btp448.
-
(2009)
Bioinformatics
, vol.25
, pp. 2762-2763
-
-
O'Dushlaine, C.1
Kenny, E.2
Heron, E.A.3
Segurado, R.4
Gill, M.5
-
28
-
-
77449140764
-
Gene and pathway-based second-wave analysis of genome-wide association studies
-
Peng G, Luo L, Siu H, Zhu Y, Hu P, et al. (2010) Gene and pathway-based second-wave analysis of genome-wide association studies. Eur J Hum Genet 18: 111-117 doi:10.1038/ejhg.2009.115.
-
(2010)
Eur J Hum Genet
, vol.18
, pp. 111-117
-
-
Peng, G.1
Luo, L.2
Siu, H.3
Zhu, Y.4
Hu, P.5
-
29
-
-
67651053605
-
Pathway analysis by adaptive combination of P-values
-
Yu K, Li Q, Bergen AW, Pfeiffer RM, Rosenberg PS, et al. (2009) Pathway analysis by adaptive combination of P-values. Genet Epidemiol 33: 700-709 doi:10.1002/gepi.20422.
-
(2009)
Genet Epidemiol
, vol.33
, pp. 700-709
-
-
Yu, K.1
Li, Q.2
Bergen, A.W.3
Pfeiffer, R.M.4
Rosenberg, P.S.5
-
31
-
-
0002338687
-
A genetic algorithm tutorial
-
Whitley D, (1994) A genetic algorithm tutorial. Statistics and Computing 4: 65-85.
-
(1994)
Statistics and Computing
, vol.4
, pp. 65-85
-
-
Whitley, D.1
-
32
-
-
0035219978
-
Applications of neural networks for gene finding
-
Sherriff A, Ott J, (2001) Applications of neural networks for gene finding. Adv Genet 42: 287-297.
-
(2001)
Adv Genet
, vol.42
, pp. 287-297
-
-
Sherriff, A.1
Ott, J.2
-
33
-
-
33644747451
-
GPNN: power studies and applications of a neural network method for detecting gene-gene interactions in studies of human disease
-
Motsinger AA, Lee SL, Mellick G, Ritchie MD, (2006) GPNN: power studies and applications of a neural network method for detecting gene-gene interactions in studies of human disease. BMC Bioinformatics 7: 39 doi:10.1186/1471-2105-7-39.
-
(2006)
BMC Bioinformatics
, vol.7
, pp. 39
-
-
Motsinger, A.A.1
Lee, S.L.2
Mellick, G.3
Ritchie, M.D.4
-
34
-
-
33750935113
-
Genetic Programming Neural Networks: A Powerful Bioinformatics Tool for Human Genetics
-
Ritchie MD, Motsinger AA, Bush WS, Coffey CS, Moore JH, (2007) Genetic Programming Neural Networks: A Powerful Bioinformatics Tool for Human Genetics. Appl Soft Comput 7: 471-479 doi:10.1016/j.asoc.2006.01.013.
-
(2007)
Appl Soft Comput
, vol.7
, pp. 471-479
-
-
Ritchie, M.D.1
Motsinger, A.A.2
Bush, W.S.3
Coffey, C.S.4
Moore, J.H.5
-
35
-
-
0036363877
-
A cellular automata approach to detecting interactions among single-nucleotide polymorphisms in complex multifactorial diseases
-
Moore JH, Hahn LW, (2002) A cellular automata approach to detecting interactions among single-nucleotide polymorphisms in complex multifactorial diseases. Pacific Symposium On Biocomputing 64: 53-64.
-
(2002)
Pacific Symposium On Biocomputing
, vol.64
, pp. 53-64
-
-
Moore, J.H.1
Hahn, L.W.2
-
36
-
-
0001334115
-
The CHC adaptive search algorithm: How to have safe search when engaging in nontraditional genetic recombination
-
Morgan Kaufmann Publishers, Inc
-
Eshelman LJ (1991) The CHC adaptive search algorithm: How to have safe search when engaging in nontraditional genetic recombination. Foundations of Genetic Algorithms. Morgan Kaufmann Publishers, Inc. 265-283.
-
(1991)
Foundations of Genetic Algorithms
, pp. 265-283
-
-
Eshelman, L.J.1
-
39
-
-
79955049746
-
Pathophysiology of rheumatoid arthritis
-
Cooles FAH, Isaacs JD, (2011) Pathophysiology of rheumatoid arthritis. Curr Opin Rheumatol 23: 233-240 doi:10.1097/BOR.0b013e32834518a3.
-
(2011)
Curr Opin Rheumatol
, vol.23
, pp. 233-240
-
-
Cooles, F.A.H.1
Isaacs, J.D.2
-
40
-
-
67649880295
-
REL, encoding a member of the NF-kappaB family of transcription factors, is a newly defined risk locus for rheumatoid arthritis
-
Gregersen PK, Amos CI, Lee AT, Lu Y, Remmers EF, et al. (2009) REL, encoding a member of the NF-kappaB family of transcription factors, is a newly defined risk locus for rheumatoid arthritis. Nat Genet 41: 820-823 doi:10.1038/ng.395.
-
(2009)
Nat Genet
, vol.41
, pp. 820-823
-
-
Gregersen, P.K.1
Amos, C.I.2
Lee, A.T.3
Lu, Y.4
Remmers, E.F.5
-
41
-
-
34548849168
-
TRAF1-C5 as a risk locus for rheumatoid arthritis-a genomewide study
-
Plenge RM, Seielstad M, Padyukov L, Lee AT, Remmers EF, et al. (2007) TRAF1-C5 as a risk locus for rheumatoid arthritis-a genomewide study. N Engl J Med 357: 1199-1209 doi:10.1056/NEJMoa073491.
-
(2007)
N Engl J Med
, vol.357
, pp. 1199-1209
-
-
Plenge, R.M.1
Seielstad, M.2
Padyukov, L.3
Lee, A.T.4
Remmers, E.F.5
-
42
-
-
49449088389
-
Genome-wide association study of rheumatoid arthritis in the Spanish population: KLF12 as a risk locus for rheumatoid arthritis susceptibility
-
Julià A, Ballina J, Cañete JD, Balsa A, Tornero-Molina J, et al. (2008) Genome-wide association study of rheumatoid arthritis in the Spanish population: KLF12 as a risk locus for rheumatoid arthritis susceptibility. Arthritis Rheum 58: 2275-2286 doi:10.1002/art.23623.
-
(2008)
Arthritis Rheum
, vol.58
, pp. 2275-2286
-
-
Julià, A.1
Ballina, J.2
Cañete, J.D.3
Balsa, A.4
Tornero-Molina, J.5
-
43
-
-
79955004052
-
Genetics of rheumatoid arthritis: time for a change!
-
de Vries R, (2011) Genetics of rheumatoid arthritis: time for a change! Curr Opin Rheumatol. 23: 227-232 doi:10.1097/BOR.0b013e3283457524.
-
(2011)
Curr Opin Rheumatol
, vol.23
, pp. 227-232
-
-
de Vries, R.1
-
44
-
-
84866120893
-
Chapter 295. Inflammatory Bowel Disease
-
In: Longo DL, Fauci AS, Kasper DL, Hauser SL, Jameson JL, Loscalzo J, eds 18th ed. McGraw-Hill Professional
-
Friedman S, Blumberg R (2011) Chapter 295. Inflammatory Bowel Disease. In: Longo DL, Fauci AS, Kasper DL, Hauser SL, Jameson JL, Loscalzo J, eds. Harrison's Principles of Internal Medicine: Volumes 1 and 2. 18th ed. McGraw-Hill Professional. 4012 p.
-
(2011)
Harrison's Principles of Internal Medicine: Volumes 1 and 2
, pp. 4012
-
-
Friedman, S.1
Blumberg, R.2
-
45
-
-
33745775434
-
Mechanisms of disease: pathogenesis of Crohn's disease and ulcerative colitis
-
Sartor RB, (2006) Mechanisms of disease: pathogenesis of Crohn's disease and ulcerative colitis. Nat Clin Pract Gastroenterol Hepatol 3: 390-407 doi:10.1038/ncpgasthep0528.
-
(2006)
Nat Clin Pract Gastroenterol Hepatol
, vol.3
, pp. 390-407
-
-
Sartor, R.B.1
-
46
-
-
75549090213
-
KEGG for representation and analysis of molecular networks involving diseases and drugs
-
Kanehisa M, Goto S, Furumichi M, Tanabe M, Hirakawa M, (2010) KEGG for representation and analysis of molecular networks involving diseases and drugs. Nucleic Acids Res 38: D355-360 doi:10.1093/nar/gkp896.
-
(2010)
Nucleic Acids Res
, vol.38
-
-
Kanehisa, M.1
Goto, S.2
Furumichi, M.3
Tanabe, M.4
Hirakawa, M.5
-
47
-
-
70350294319
-
Genephony: a knowledge management tool for genome-wide research
-
Nuzzo A, Riva A, (2009) Genephony: a knowledge management tool for genome-wide research. BMC Bioinformatics 10: 278 doi:10.1186/1471-2105-10-278.
-
(2009)
BMC Bioinformatics
, vol.10
, pp. 278
-
-
Nuzzo, A.1
Riva, A.2
-
48
-
-
0029078180
-
Early-onset pauciarticular juvenile chronic arthritis is associated with a mutation in the Y-box of the HLA-DQA1 promoter
-
Haas JP, Kimura A, Truckenbrodt H, Suschke J, Sasazuki T, et al. (1995) Early-onset pauciarticular juvenile chronic arthritis is associated with a mutation in the Y-box of the HLA-DQA1 promoter. Tissue Antigens 45: 317-321.
-
(1995)
Tissue Antigens
, vol.45
, pp. 317-321
-
-
Haas, J.P.1
Kimura, A.2
Truckenbrodt, H.3
Suschke, J.4
Sasazuki, T.5
-
49
-
-
68349146112
-
Understanding synergy in genetic interactions
-
Pérez-Pérez JM, Candela H, Micol JL, (2009) Understanding synergy in genetic interactions. Trends Genet 25: 368-376 doi:10.1016/j.tig.2009.06.004.
-
(2009)
Trends Genet
, vol.25
, pp. 368-376
-
-
Pérez-Pérez, J.M.1
Candela, H.2
Micol, J.L.3
-
50
-
-
0033230044
-
Copying out our ABCs: the role of gene redundancy in interpreting genetic hierarchies
-
Martienssen R, Irish V, (1999) Copying out our ABCs: the role of gene redundancy in interpreting genetic hierarchies. Trends Genet 15: 435-437.
-
(1999)
Trends Genet
, vol.15
, pp. 435-437
-
-
Martienssen, R.1
Irish, V.2
|