Evidence of an increased pathogenic footprint in the lingual microbiome of untreated HIV infected patients

BMC Microbiology

Volumn 12, Issue , 2012, Pages

  Dang, Angeline T ^a,d   Cotton, Sean ^b   Sankaran Walters, Sumathi ^a   Li, Chin Shang ^c   Lee, Chia Yuan Michael ^d   Dandekar, Satya ^a   Paster, Bruce J ^b,e   George, Michael D ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b FORSYTH INSTITUTE   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

^e HARVARD SCHOOL OF DENTAL MEDICINE   (United States)

Author keywords

CD4+ T cells; Commensal; Dysbiosis; HIV; HOMIM; Microbiome; Microbiota; Oral mucosa; Streptococcus

Indexed keywords

ANTIRETROVIRUS AGENT;

ANTIVIRAL THERAPY; ARTICLE; BACTERIAL COLONIZATION; BACTERIAL GROWTH; CAMPYLOBACTER; CAMPYLOBACTER CONCISUS; CAMPYLOBACTER RECTUS; CD4 CD8 RATIO; CD4 LYMPHOCYTE COUNT; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CLINICAL ARTICLE; COMMENSAL; COMMUNITY STRUCTURE; CONTROLLED STUDY; EUBACTERIUM; FEMALE; FIRMICUTES; FUSOBACTERIUM; GEMELLA; GRANULICATELLA; HAEMOPHILUS; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTED PATIENT; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; LACHNOSPIRACEAE; MALE; MEGASPHAERA; MEGASPHAERA MICRONUCIFORMIS; MICROARRAY ANALYSIS; MICROBIAL COMMUNITY; MOUTH FLORA; NEISSERIA; NEISSERIA FLAVESCENS; NONHUMAN; PREVOTELLA; PREVOTELLA PALLENS; ROTHIA; SOLOBACTERIUM; SPECIES; STREPTOCOCCUS; TAXONOMY; TONGUE; TREATMENT OUTCOME; VEILLONELLA; VEILLONELLA PARVULA; VIREMIA;

ADULT; AGED; ANTI-HIV AGENTS; BACTERIA; BACTERIAL INFECTIONS; FEMALE; HIV INFECTIONS; HUMANS; MALE; METAGENOME; MICROARRAY ANALYSIS; MIDDLE AGED; TONGUE;

BACTERIA (MICROORGANISMS); CAMPYLOBACTER; MEGASPHAERA; NEISSERIA FLAVESCENS; PREVOTELLA; STREPTOCOCCUS; VEILLONELLA;

EID: 84866080066     PISSN: None     EISSN: 14712180     Source Type: Journal    
DOI: 10.1186/1471-2180-12-153     Document Type: Article

References (43)

1. The dynamics of CD4+ T-cell depletion in HIV disease. McCune JM, Nature 2001 410 6831 974 979
2. Oral candidosis in HIV-infected patients. Egusa H, Soysa NS, Ellepola AN, Yatani H, Samaranayake LP, Curr HIV Res 2008 6 6 485 499
3. T cell depletion in HIV-1 infection: how CD4+ T cells go out of stock. Hazenberg MD, Hamann D, Schuitemaker H, Miedema F, Nat Immunol 2000 1 4 285 289
4. Oral manifestations of HIV disease. Reznik DA, Top HIV Med 2005 13 5 143 148
5. Immunohistochemical evaluation of T cells in oral lesions from human immunodeficiency virus-positive persons with oropharyngeal candidiasis. Myers TA, Leigh JE, Arribas AR, Hager S, Clark R, Lilly E, Fidel PL, Infect Immun 2003 71 2 956 963
6. Characterization of the immune status of CD8+ T cells in oral lesions of human immunodeficiency virus-infected persons with oropharyngeal Candidiasis. Leigh JE, McNulty KM, Fidel PL, Clin Vaccine Immunol 2006 13 6 678 683
7. The effects of HIV infection on oral mucosal immunity. Challacombe SJ, Naglik JR, Adv Dent Res 2006 19 1 29 35
8. Th17 cells, HIV and the gut mucosal barrier. Dandekar S, George MD, Baumler AJ, Curr Opin HIV AIDS 2010 5 2 173 178
9. Rapid onset of intestinal epithelial barrier dysfunction in primary human immunodeficiency virus infection is driven by an imbalance between immune response and mucosal repair and regeneration. Sankaran S, George MD, Reay E, Guadalupe M, Flamm J, Prindiville T, Dandekar S, J Virol 2008 82 1 538 545
10. Heightened cytotoxic responses and impaired biogenesis contribute to early pathogenesis in the oral mucosa of simian immunodeficiency virus-infected rhesus macaques. George MD, Verhoeven D, Sankaran S, Glavan T, Reay E, Dandekar S, Clin Vaccine Immunol 2009 16 2 277 281
11. Biofilms: Survival mechanisms of clinically relevant microorganisms. Donlan RM, Costerton JW, Clin Microbiol Rev 2002 15 2 167
12. Human oral cavity as a model for the study of genome-genome interactions. In: 2003. Foster JS, Palmer RJ, Kolenbrander PE, Marine Biological Laboratory 2003 204 2 200 204
13. Riddle of biofilm resistance. Lewis K, Antimicrob Agents Chemother 2001 45 4 999 1007
14. Defining the normal bacterial flora of the oral cavity. Aas JA, Paster BJ, Stokes LN, Olsen I, Dewhirst FE, J Clin Microbiol 2005 43 11 5721 5732
15. Commensal bacteria (normal microflora), mucosal immunity and chronic inflammatory and autoimmune diseases. Tlaskalova-Hogenova H, Stepankova R, Hudcovic T, Tuckova L, Cukrowska B, Lodinova-Zadnikova R, Kozakova H, Rossmann P, Bartova J, Sokol D, et al. Immunol Lett 2004 93 2-3 97 108
16. Contribution of microbial-associated molecules in innate mucosal responses. Alexopoulou L, Kontoyiannis D, Cell Mol Life Sci 2005 62 12 1349 1358
17. Bacterial modulation of mucosal innate immunity. Kelly D, Conway S, Mol Immunol 2005 42 8 895 901
18. The oral metagenome in health and disease. Belda-Ferre P, Alcaraz LD, Cabrera-Rubio R, Romero H, Simon-Soro A, Pignatelli M, Mira A, ISME J 2012 6 1 46 56
19. The human oral microbiome. Dewhirst FE, Chen T, Izard J, Paster BJ, Tanner AC, Yu WH, Lakshmanan A, Wade WG, J Bacteriol 2010 192 19 5002 5017
20. Streptococcus mitis: walking the line between commensalism and pathogenesis. Mitchell J, Mol Oral Microbiol 2011 26 2 89 98
21. Defining the healthy "core microbiome" of oral microbial communities. Zaura E, Keijser BJ, Huse SM, Crielaard W, BMC Microbiol 2009 9 259
22. Effects of long-term use of HAART on oral health status of HIV-infected subjects. Nittayananta W, Talungchit S, Jaruratanasirikul S, Silpapojakul K, Chayakul P, Nilmanat A, Pruphetkaew N, J Oral Pathol Med 2010 39 5 397 406
23. Exploring the oral microbiota of children at various developmental stages of their dentition in the relation to their oral health. Crielaard W, Zaura E, Schuller AA, Huse SM, Montijn RC, Keijser BJ, BMC Med Genomics 2011 4 22
24. de Buochberg MS, Carriere C. Marchandin H, Jumas-Bilak E, Gay B, Teyssier C, Jean-Pierre H, Carlier JP: Phylogenetic analysis of some Sporomusa sub-branch members isolated from human clinical specimens: description of Megasphaera micronuciformis sp. nov. Int J Syst Evol Microbiol 2003 53 Pt 2 547 553
25. Notch-1 signaling regulates intestinal epithelial barrier function, through interaction with CD4+ T cells, in mice and humans. Dahan S, Rabinowitz KM, Martin AP, Berin MC, Unkeless JC, Mayer L, Gastroenterology 2011 140 2 550 559
26. Jag2-Notch1 signaling regulates oral epithelial differentiation and palate development. Casey LM, Lan Y, Cho ES, Maltby KM, Gridley T, Jiang R, Developmental dynamics: an official publication of the American Association of Anatomists 2006 235 7 1830 1844
27. Th17 cells, Job's syndrome and HIV: opportunities for bacterial and fungal infections. Milner JD, Sandler NG, Douek DC, Curr Opin HIV AIDS 2010 5 2 179 183
28. IL-22 mediates host defense against an intestinal intracellular parasite in the absence of IFN-gamma at the cost of Th17-driven immunopathology. Stange J, Hepworth MR, Rausch S, Zajic L, Kuhl AA, Uyttenhove C, Renauld JC, Hartmann S, Lucius R, J Immunol 2012 188 5 2410 2418
29. Salivary histatin-5 and oral fungal colonisation in HIV+individuals. Torres SR, Garzino-Demo A, Meiller TF, Meeks V, Jabra-Rizk MA, Mycoses 2009 52 1 11 15
30. HIV type 1 fails to trigger innate immune factor synthesis in differentiated oral epithelium. Nittayananta W, Hladik F, Klausner M, Harb S, Dale BA, Coombs RW, AIDS Res Hum Retroviruses 2009 25 10 1013 1021
31. Leukocyte granule proteins mobilize innate host defenses and adaptive immune responses. Chertov O, Yang D, Howard OM, Oppenheim JJ, Immunol Rev 2000 177 68 78
32. The Genus Veillonella. I.General Cultural, Ecological, and Biochemical Considerations. Rogosa M, J Bacteriol 1964 87 162 170
33. Cultivable anaerobic microbiota of severe early childhood caries. Tanner AC, Mathney JM, Kent RL, Chalmers NI, Hughes CV, Loo CY, Pradhan N, Kanasi E, Hwang J, Dahlan MA, et al. J Clin Microbiol 2011 49 4 1464 1474
34. Evaluation of the microbiota of primary endodontic infections using checkerboard DNA-DNA hybridization. Sassone L, Fidel R, Figueiredo L, Fidel S, Faveri M, Feres M, Oral Microbiol Immunol 2007 22 6 390 397
35. Coaggregation properties of human oral Veillonella spp.: relationship to colonization site and oral ecology. Hughes CV, Kolenbrander PE, Andersen RN, Moore LV, Appl Environ Microbiol 1988 54 8 1957 1963
36. Receptor recognition of and immune intracellular pathways for Veillonella parvula lipopolysaccharide. Matera G, Muto V, Vinci M, Zicca E, Abdollahi-Roodsaz S, van de Veerdonk FL, Kullberg BJ, Liberto MC, van der Meer JW, Foca A, et al. Clin Vaccine Immunol 2009 16 12 1804 1809
37. Oral manifestations associated with HIV infection. Nokta M, Curr HIV/AIDS Rep 2008 5 1 5 12
38. Effects of highly active antiretroviral therapy on HIV-1-associated oral complications. Parveen Z, Acheampong E, Pomerantz RJ, Jacobson JM, Wigdahl B, Mukhtar M, Curr HIV Res 2007 5 3 281 292
39. Oral manifestation of HIV/AIDS. Arotiba JT, Arowojolu MO, Fasola AO, Denloye OO, Obiechina AE, Afr J Med Med Sci 2006 35 Suppl 13 18
40. HIV-associated Kaposi sarcoma in African children. Feller L, Khammissa RA, Gugushe TS, Chikte UM, Wood NH, Meyerov R, Lemmer J, SADJ 2010 65 1 20 22
41. Molecular microbial diagnosis. Paster BJ, Dewhirst FE, Periodontol 2009 51 38 44
42. Comparisons of subgingival microbial profiles of refractory periodontitis, severe periodontitis, and periodontal health using the human oral microbe identification microarray. Colombo AP, Boches SK, Cotton SL, Goodson JM, Kent R, Haffajee AD, Socransky SS, Hasturk H, Van Dyke TE, Dewhirst F, et al. J Periodontol 2009 80 9 1421 1432
43. Bacterial diversity in necrotizing ulcerative periodontitis in HIV-positive subjects. Paster BJ, Russell MK, Alpagot T, Lee AM, Boches SK, Galvin IL, Dewhirst FE, Ann Periodontol 2002 7 1 8 16