Iron deficiency anaemia in pregnancy and postpartum: Pathophysiology and effect of oral versus intravenous iron therapy

Journal of Pregnancy

Volumn 2012, Issue , 2012, Pages

  Khalafallah, Alhossain A ^a,b   Dennis, Amanda E ^a,b  

^a LAUNCESTON GENERAL HOSPITAL   (Australia)

^b UNIVERSITY OF TASMANIA   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIANEMIC AGENT; BIOLOGICAL MARKER; IRON; IRON DERIVATIVE;

BLOOD; BLOOD TRANSFUSION; FEMALE; HUMAN; INTRAVENOUS DRUG ADMINISTRATION; IRON DEFICIENCY ANEMIA; METABOLISM; ORAL DRUG ADMINISTRATION; PREGNANCY; PREGNANCY COMPLICATION; PUERPERAL DISORDER; REVIEW;

ADMINISTRATION, ORAL; ANEMIA, IRON-DEFICIENCY; BIOLOGICAL MARKERS; BLOOD TRANSFUSION; FEMALE; HEMATINICS; HUMANS; INFUSIONS, INTRAVENOUS; IRON; IRON COMPOUNDS; PREGNANCY; PREGNANCY COMPLICATIONS, HEMATOLOGIC; PUERPERAL DISORDERS;

EID: 84866077520     PISSN: 20902727     EISSN: 20902735     Source Type: Journal    
DOI: 10.1155/2012/630519     Document Type: Review

References (57)

1. de Benoist D., McLean E., Egli I., Cogswell M., Worldwide prevalence of anaemia 19932005. 2008
2. World Health Organization [WHO], The Prevalence of Anaemia in Women: a tabulation of available information. Division of Family Health, Maternal Health and Safe Motherhood Programme, Division of Health Protection and Promotion, Nutrition Programme; WHO, 2nd ed. World Health Organization, Geneva, Switzerland, 1992
3. ACC/SCN (United Nations Administrative Committee on Coordination/Standing Committee on Nutrition), Fifth report on the world nutrition situation: Nutrition for improved development outcomes. Geneva, Switzerland, accscn@who.org, 2004
4. Zimmermann M. B., Hurrell R. F., Nutritional iron deficiency. Lancet 2007 370 9586 511 520 2-s2.0-34547652466 10.1016/S0140-6736(07)61235-5 (Pubitemid 47214636)
5. Maberly G. F., Trowbridge F. L., Yip R., Sullivan K. M., West C. E., Programs against micronutrient malnutrition: ending hidden hunger. Annual Review of Public Health 1994 15 277 301 2-s2.0-0028305088 (Pubitemid 24179004)
6. Iron deficiency anaemia: assessment, prevention and control. World Health Organization Publication 2001 WHO/NHD/01.3
7. Reveiz L., Gyte G. M., Cuervo L. G., Casasbuenas A., Treatments for iron-deficiency anaemia in pregnancy. Cochrane Database of Systematic Reviews 2011 10 CD003094 2-s2.0-34447336726
8. Khalafallah A., Mohamed M., Nutritional iron deficiency. Anemia 2012 Rijeka, Croatia InTech
9. Looker A. C., Dallman P. R., Carroll M. D., Gunter E. W., Johnson C. L., Prevalence of iron deficiency in the United States. Journal of the American Medical Association 1997 277 12 973 976 2-s2.0-0030976067 (Pubitemid 27142364)
10. Goddard A. F., James M. W., McIntyre A. S., Scott B. B., Guidelines for the management of iron deficiency anaemia. Gut 2000 46 1 5 10.1136/gut.46. suppl4.iv1
11. Valore E. V., Ganz T., Posttranslational processing of hepcidin in human hepatocytes is mediated by the prohormone convertase furin. Blood Cells, Molecules, and Diseases 2008 40 1 132 138 2-s2.0-36549034762 10.1016/j.bcmd.2007.07.009 (Pubitemid 350192311)
12. Meyron-Holtz E. G., Moshe-Belizowski S., Cohen L. A., A possible role for secreted ferritin in tissue iron distribution. Journal of Neural Transmission 2011 118 337 347 2-s2.0-79551508632 10.1007/s00702-011-0582-0
13. Galy B., Ferring-Appel D., Sauer S. W., Iron regulatory proteins secure mitochondrial iron sufficiency and function. Cell Metabolism 2010 12 194 201
14. Weinstein D. A., Roy C. N., Fleming M. D., Loda M. F., Wolfsdorf J. I., Andrews N. C., Inappropriate expression of hepcidin is associated with iron refractory anemia: implications for the anemia of chronic disease. Blood 2002 100 10 3776 3781 2-s2.0-0037111732 10.1182/blood-2002-04-1260 (Pubitemid 35303951)
15. Nemeth E., Ganz T., The role of hepcidin in iron metabolism. Acta Haematologica 2009 122 2-3 78 86 2-s2.0-70450214396 10.1159/000243791
16. Panel on Micronutrients, Food and Nutrition Board, Institute of Medicine-National Academy of Sciences. Dietary reference intakes: recommended intakes for individuals, vitamins, 2001
17. Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. pp. 772773, National Academy Press, Washington, DC, USA
18. Institute of Medicine, Dietary Reference Intakes (DRIs) for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. National Academy Press, Washington, DC, USA, 2002
19. Guyatt G. H., Oxman A. D., Ali M., Willan A., McIlroy W., Patterson C., Laboratory diagnosis of iron-deficiency anemia: an overview. Journal of General Internal Medicine 1992 7 2 145 153 2-s2.0-0026511106
20. Hansen T. M., Hansen N. E., Serum ferritin as indicator of iron responsive anaemia in patients with rheumatoid arthritis. Annals of the Rheumatic Diseases 1986 45 7 596 602 2-s2.0-0022492419 (Pubitemid 16066086)
21. Punnonen K., Irjala K., Rajamäki A., Serum transferrin receptor and its ratio to serum ferritin in the diagnosis of iron deficiency. Blood 1997 89 3 1052 1057 2-s2.0-0030976033 (Pubitemid 27121300)
22. Kemna E. H. J. M., Tjalsma H., Podust V. N., Swinkels D. W., Mass spectrometry-based hepcidin measurements in serum and urine: analytical aspects and clinical implications. Clinical Chemistry 2007 53 4 620 628 2-s2.0-34147197662 10.1373/clinchem.2006.079186 (Pubitemid 46580231)
23. Pasricha S. R., McQuilten Z., Westerman M., Keller A., Nemeth E., Ganz T., Wood E., Serum hepcidin as a diagnostic test of iron deficiency in premenopausal female blood donors. Haematologica 2011 96 8 1099 1105 2-s2.0-79961085126 10.3324/haematol.2010.037960
24. Zini G., Di Mario A., Garzia M., Bianchi M., D'Onofrio G., Reticulocyte population data in different erythropoietic states. Journal of Clinical Pathology 2011 64 2 159 163 2-s2.0-79251511996 10.1136/jcp.2010.082669
25. Kumar A., Jain S., Singh N. P., Singh T., Oral versus high dose parenteral iron supplementation in pregnancy. International Journal of Gynecology and Obstetrics 2005 89 1 7 13 2-s2.0-15044350863 10.1016/j.ijgo.2005. 01.016 (Pubitemid 40381133)
26. Jacobs P., Johnson G., Wood L., Oral iron therapy in human subjects, comparative absorption between ferrous salts and iron polymaltose. Journal of Medicine 1984 15 5-6 367 377 2-s2.0-0021590728 (Pubitemid 15006117)
27. Maxton D. G., Thompson R. P. H., Hider R. C., Absorption of iron from ferric hydroxypyranone complexes. British Journal of Nutrition 1994 71 2 203 207 2-s2.0-0028157154 (Pubitemid 24062827)
28. Sharma N., Iron absorption: IPC therapy is superior to conventional iron salts. Obstetrics & Gynecology 2001 515 519
29. Geisser P., In vitro studies on interactions of iron salts and complexes with food-stuffs and medicaments. Arzneimittel-Forschung 1990 40 7 754 760 2-s2.0-0025337109 (Pubitemid 20210685)
30. Khalafallah A., Dennis A., Bates J., Bates G., Robertson I. K., Smith L., Ball M. J., Seaton D., Brain T., Rasko J. E. J., A prospective randomized, controlled trial of intravenous versus oral iron for moderate iron deficiency anaemia of pregnancy. Journal of Internal Medicine 2010 268 3 286 295 2-s2.0-77955248295 10.1111/j.1365-2796.2010.02251.x
31. Auerbach M., Ballard H., Glaspy J., Clinical update: intravenous iron for anaemia. Lancet 2007 369 9572 1502 1504 2-s2.0-34247615981 10.1016/S0140- 6736(07)60689-8 (Pubitemid 46670290)
32. Jenkins A., Using iron dextran to treat iron-deficiency anaemia. Hospital Pharmacist 2005 12 6 224 225 2-s2.0-20544436934 (Pubitemid 40839981)
33. Lawrence R., Helenek M., Development and comparison of iron dextran products. PDA Journal of Pharmaceutical Science and Technology 1998 52 5 190 197 2-s2.0-0031738096 (Pubitemid 28548896)
34. Auerbach M., Goodnough L. T., Picard D., Maniatis A., The role of intravenous iron in anemia management and transfusion avoidance. Transfusion 2008 48 5 988 1000 2-s2.0-42949084115 10.1111/j.1537-2995.2007.01633.x (Pubitemid 351614910)
35. Auerbach M., Rodgers G. M., Intravenous iron. New England Journal of Medicine 2007 357 1 93 94 2-s2.0-34347381712 10.1056/NEJMc070203 (Pubitemid 47026766)
36. Hamstra R. D., Block M. H., Schocket A. L., Intravenous iron dextran in clinical medicine. Journal of the American Medical Association 1980 243 17 1726 1731 2-s2.0-0018898174 10.1001/jama.243.17.1726 (Pubitemid 10148807)
37. Faich G., Strobos J., Matzke G. R., Sodium ferric gluconate complex in sucrose: safer intravenous iron therapy than iron dextrans. American Journal of Kidney Diseases 1999 33 3 464 597 2-s2.0-0033012811
38. Burns D. L., Pomposelli J. J., Toxicity of parenteral iron dextran therapy. Kidney International, Supplement 1999 55 69 S119 S124 2-s2.0-0032962843 (Pubitemid 29113592)
39. Michael B., Coyne D. W., Fishbane S., Folkert V., Lynn R., Nissenson A. R., Agarwal R., Eschbach J. W., Fadem S. Z., Trout J. R., Strobos J., Warnock D. G., Sodium ferric gluconate complex in hemodialysis patients: adverse reactions compared to placebo and iron dextran. Kidney International 2002 61 5 1830 1839 2-s2.0-0036233761 10.1046/j.1523-1755.2002.00314.x (Pubitemid 34437938)
40. Fishbone S., Kowalski E. A., The comparative safety of intravenous iron dextran, iron saccharate, and sodium ferric gluconate. Seminars in Dialysis 2000 13 6 381 384 2-s2.0-0034323822
41. Bayoumeu F., Subiran-Buisset C., Baka N. E., Legagneur H., Monnier-Barbarino P., Laxenaire M. C., Iron therapy in iron deficiency anemia in pregnancy: intravenous route versus oral route. American Journal of Obstetrics and Gynecology 2002 186 3 518 522 2-s2.0-0036126968 10.1067/mob.2002.121894 (Pubitemid 34234167)
42. Al R. A., Unlubilgin E., Kandemir O., Yalvac S., Cakir L., Haberal A., Intravenous versus oral iron for treatment of anemia in pregnancy: a randomized trial. Obstetrics and Gynecology 2005 106 6 1335 1340 2-s2.0-27944480880 (Pubitemid 41668954)
43. Reveiz L., Gyte G. M., Cuervo L. G., Treatments for iron-deficiency anaemia in pregnancy. Cochrane Database of Systematic Reviews 2007 2 CD003094 2-s2.0-34447336726
44. Garg M., Morrison G., Friedman A., Lau A., Lau D., Gibson P. R., A rapid infusion protocol is safe for total dose iron polymaltose: time for change. Internal Medicine Journal 2011 41 7 548 554 2-s2.0-79960453840 10.1111/j.1445-5994.2010.02356.x
45. Manoharan A., Ramakrishna R., Pereira B., Delayed adverse reactions to total-dose intravenous iron polymaltose. Internal Medicine Journal 2009 39 12 857 2-s2.0-73649095154 10.1111/j.1445-5994.2009.02077.x
46. Monograph ferumoxytol (Feraheme). AMAG Pharmaceuticals Inc., 2009
47. Rosner M. H., Auerbach M., Ferumoxytol for the treatment of iron deficiency. Expert Review of Hematology 2011 4 4 399 406 2-s2.0-79961040926 10.1586/ehm.11.31
48. Kulnigg S., Stoinov S., Simanenkov V., Dudar L. V., Karnafel W., Garcia L. C., Sambuelli A. M., D'Haens G., Gasche C., A novel intravenous iron formulation for treatment of anemia in inflammatory bowel disease: the ferric carboxymaltose (FERINJECT®) randomized controlled trial. American Journal of Gastroenterology 2008 103 5 1182 1192 2-s2.0-43549093318 10.1111/j.1572-0241. 2007.01744.x (Pubitemid 351677967)
49. Qunibi W., Dinh Q., Benjamin J., Safety and tolerability profile of ferric carboxymaltose (FCM) a new high dose intravenous iron, across ten multi-center trials. Journal of the American Society of Nephrology 2007 18, SU-PO1029
50. Kalra P. A., Introducing iron isomaltoside 1000 (Monofer®) development rationale and clinical experience. NDT Plus 2011 4 1 i10 i13 2-s2.0-79957983220 10.1093/ndtplus/sfr042
51. Jahn M. R., Andreasen H. B., Fütterer S., Nawroth T., Schünemann V., Kolb U., Hofmeister W., Muñoz M., Bock K., Meldal M., Langguth P., A comparative study of the physicochemical properties of iron isomaltoside 1000 (Monofer®), a new intravenous iron preparation and its clinical implications. European Journal of Pharmaceutics and Biopharmaceutics 2011 78 3 480 491 2-s2.0-79960617268 10.1016/j.ejpb.2011.03.016
52. Breymann C., Gliga F., Bejenariu C., Strizhova N., Comparative efficacy and safety of intravenous ferric carboxymaltose in the treatment of postpartum iron deficiency anemia. International Journal of Gynecology and Obstetrics 2008 101 1 67 73 2-s2.0-40649100958 10.1016/j.ijgo.2007.10.009
53. Seid M. H., Derman R. J., Baker J. B., Banach W., Goldberg C., Rogers R., Ferric carboxymaltose injection in the treatment of postpartum iron deficiency anemia: a randomized controlled clinical trial. American Journal of Obstetrics and Gynecology 2008 199 4 435.e1 435.e7 2-s2.0-52949101033 10.1016/j.ajog.2008. 07.046
54. Van Wyck D. B., Martens M. G., Seid M. H., Baker J. B., Mangione A., Intravenous ferric carboxymaltose compared with oral iron in the treatment of postpartum anemia: a randomized controlled trial. Obstetrics and Gynecology 2007 110 2 I 267 278 2-s2.0-34548462994 10.1097/01.AOG.0000275286.03283.18 (Pubitemid 47356650)
55. Goodnough L. T., Van Wyck D. B., Mangione A., Morrison J., Hadley P. E., Jehle J. A., Large-dose intravenous ferric carboxymaltose injection for iron deficiency anemia in heavy uterine bleeding: a randomized, controlled trial. Transfusion 2009 49 12 2719 2728 2-s2.0-71849101678 10.1111/j.1537-2995.2009. 02327.x
56. Isbister J. P., Shander A., Spahn D. R., Erhard J., Farmer S. L., Hofmann A., Adverse blood transfusion outcomes: establishing causation. Transfusion Medicine Reviews 2011 25 2 89 101 2-s2.0-79952707725 10.1016/j.tmrv.2010.11.001
57. Aickin M., Gensler H., Adjusting for multiple testing when reporting research results: the Bonferroni vs Holm methods. American Journal of Public Health 1996 86 5 726 728 2-s2.0-0029966556 (Pubitemid 26145488)