CD14dimCD16+ and CD14+CD16+ monocytes in obesity and during weight loss: Relationships with fat mass and subclinical atherosclerosis

Arteriosclerosis, Thrombosis, and Vascular Biology

Volumn 31, Issue 10, 2011, Pages 2322-2330

  Poitou, Christine ^a,b,c,d,e   Dalmas, Elise ^a,b,c   Renovato, Mariana ^a,b,c   Benhamo, Vanessa ^a,b,c   Hajduch, Froogh ^a,b,c   Abdennour, Meriem ^a,b,f   Kahn, Jean François ^d   Veyrie, Nicolas ^a,b,c,g   Rizkalla, Salwa ^a,b,c,e   Fridman, Wolf Hervé ^a,b,c   Sautès Fridman, Catherine ^a,b,c   Clément, Karine ^a,b,c,d,e   Cremer, Isabelle ^a,b,c  

^a INSERM   (France)

^b SORBONNE UNIVERSITÉ   (France)

^c UNIVERSITÉ PARIS DESCARTES   (France)

^d PITIÉ SALPÊTRIÈRE HOSPITAL   (France)

^e Centre de Recherche en Nutrition Humaine Ile de France   (France)

^f Research and Development Department   (France)

^g NONE   (France)

Author keywords

atherosclerosis; blood cells; diabetes mellitus; nutrition; obesity

Indexed keywords

ADIPONECTIN; C REACTIVE PROTEIN; CD14 ANTIGEN; CD16 ANTIGEN; GLUCOSE; GLYCOSYLATED HEMOGLOBIN; INSULIN; LIPID; FC RECEPTOR; FCGR3B PROTEIN, HUMAN; GLYCOSYLPHOSPHATIDYLINOSITOL ANCHORED PROTEIN;

ADULT; ARTERIAL WALL THICKNESS; ARTICLE; ATHEROSCLEROSIS; BODY FAT; CONTROLLED STUDY; DIABETES MELLITUS; DIABETIC PATIENT; DISEASE ASSOCIATION; DISEASE MARKER; FEMALE; GLUCOSE BLOOD LEVEL; GLUCOSE TOLERANCE; HUMAN; INFLAMMATION; INSULIN SENSITIVITY; LOW CALORY DIET; MAJOR CLINICAL STUDY; MALE; MONOCYTE; OBESITY; PRIORITY JOURNAL; PROTEIN EXPRESSION; STOMACH SURGERY; WEIGHT REDUCTION; ANALYSIS OF VARIANCE; ASYMPTOMATIC DISEASE; BLOOD; CALORIC RESTRICTION; ECHOGRAPHY; FLOW CYTOMETRY; FRANCE; IMMUNOLOGY; MIDDLE AGED; NON INSULIN DEPENDENT DIABETES MELLITUS; PATHOPHYSIOLOGY; PHOTON ABSORPTIOMETRY; PROSPECTIVE STUDY; REGRESSION ANALYSIS; STOMACH BYPASS; TIME; TREATMENT OUTCOME;

ABSORPTIOMETRY, PHOTON; ADIPOSITY; ADULT; ANALYSIS OF VARIANCE; ANTIGENS, CD14; ASYMPTOMATIC DISEASES; ATHEROSCLEROSIS; CALORIC RESTRICTION; DIABETES MELLITUS, TYPE 2; FEMALE; FLOW CYTOMETRY; FRANCE; GASTRIC BYPASS; GPI-LINKED PROTEINS; HUMANS; MALE; MIDDLE AGED; MONOCYTES; OBESITY; PROSPECTIVE STUDIES; RECEPTORS, IGG; REGRESSION ANALYSIS; TIME FACTORS; TREATMENT OUTCOME; WEIGHT LOSS;

EID: 80052962325     PISSN: 10795642     EISSN: 15244636     Source Type: Journal    
DOI: 10.1161/ATVBAHA.111.230979     Document Type: Article

References (40)

1. Dalmas E, Rouault C, Abdennour M, Rovere C, Rizkalla S, Bar-Hen A, Nahon JL, Bouillot JL, Guerre-Millo M, Clement K, Poitou C. Variations in circulating inflammatory factors are related to changes in caloric and carbohydrates intake early in the course of surgery-induced weight reduction. Am J Clin Nutr. 2011 Jun 15. [Epub ahead of print].
2. Woollard KJ, Geissmann F. Monocytes in atherosclerosis: subsets and functions. Nat Rev Cardiol. 2010;7:77-86.
3. Fernandez-Real JM, Pickup JC. Innate immunity, insulin resistance and type 2 diabetes. Trends Endocrinol Metab. 2008;19:10-16.
4. Waterhouse DF, Cahill RA, Sheehan F, McCreery C. Prediction of calculated future cardiovascular disease by monocyte count in an asymptomatic population. Vasc Health Risk Manag. 2008;4:177-187. (Pubitemid 351460859)
5. Chapman CM, Beilby JP, McQuillan BM, Thompson PL, Hung J. Monocyte count, but not C-reactive protein or interleukin-6, is an independent risk marker for subclinical carotid atherosclerosis. Stroke. 2004; 35:1619-1624. (Pubitemid 38823636)
6. Nasir K, Guallar E, Navas-Acien A, Criqui MH, Lima JA. Relationship of monocyte count and peripheral arterial disease: results from the National Health and Nutrition Examination Survey 1999-2002. Arte-rioscler Thromb Vasc Biol. 2005;25:1966-1971. (Pubitemid 41243470)
7. Johnsen SH, Fosse E, Joakimsen O, Mathiesen EB, Stensland-Bugge E, Njolstad I, Arnesen E. Monocyte count is a predictor of novel plaque formation: a 7-year follow-up study of 2610 persons without carotid plaque at baseline the Tromso Study. Stroke. 2005;36:715-719.
8. Pandzic Jaksic V, Gizdic B, Miletic Z, Ostovic KT, Jaksic O. Monocytes in metabolic disorders-opportunities for flow cytometry contributions. Coll Antropol. 2010;34:319-325.
9. Gordon S, Taylor PR. Monocyte and macrophage heterogeneity. Nat Rev Immunol. 2005;5:953-964. (Pubitemid 41746764)
10. Passlick B, Flieger D, Ziegler-Heitbrock HW. Identification and characterization of a novel monocyte subpopulation in human peripheral blood. Blood. 1989;74:2527-2534. (Pubitemid 19286475)
11. Ziegler-Heitbrock L. The CD14+ CD16+ blood monocytes: their role in infection and inflammation. J Leukoc Biol. 2007;81:584-592. (Pubitemid 46393535)
12. Cottam DR, Schaefer PA, Shaftan GW, Velcu L, Angus LD. Effect of surgically-induced weight loss on leukocyte indicators of chronic inflammation in morbid obesity. Obes Surg. 2002;12:335-342. (Pubitemid 34621025)
13. Rogacev KS, Ulrich C, Blomer L, Hornof F, Oster K, Ziegelin M, Cremers B, Grenner Y, Geisel J, Schlitt A, Kohler H, Fliser D, Girndt M, Heine GH. Monocyte heterogeneity in obesity and subclinical atherosclerosis. Eur Heart J. 2010;31:369-376.
14. Schlitt A, Heine GH, Blankenberg S, Espinola-Klein C, Dopheide JF, Bickel C, Lackner KJ, Iz M, Meyer J, Darius H, Rupprecht HJ. CD14 +CD16 + monocytes in coronary artery disease and their relationship to serum TNF-alpha levels. Thromb Haemost. 2004;92:419-424. (Pubitemid 39172323)
15. Nockher WA, Scherberich JE. Expanded CD14+ CD16+ monocyte subpopulation in patients with acute and chronic infections undergoing hemodialysis. Infect Immun. 1998;66:2782-2790. (Pubitemid 28261784)
16. Heine GH, Ulrich C, Seibert E, Seiler S, Marell J, Reichart B, Krause M, Schlitt A, Kohler H, Girndt M. CD14(++)CD16+ monocytes but not total monocyte numbers predict cardiovascular events in dialysis patients. Kidney Int. 2008;73:622-629. (Pubitemid 351264115)
17. Rogacev KS, Seiler S, Zawada AM, Reichart B, Herath E, Roth D, Ulrich C, Fliser D, Heine GH. CD14 + +CD16+ monocytes and cardiovascular outcome in patients with chronic kidney disease. Eur Heart J. 2011;32: 84-92.
18. Saha P, Geissmann F. Toward a functional characterization of blood monocytes. Immunol Cell Biol. 2010;89:2-4.
19. Cros J, Cagnard N, Woollard K, Patey N, Zhang SY, Senechal B, Puel A, Biswas SK, Moshous D, Picard C, Jais JP, D'Cruz D, Casanova JL, Trouillet C, Geissmann F. Human CD14dim monocytes patrol and sense nucleic acids and viruses via TLR7 and TLR8 receptors. Immunity. 2010;33:375-386.
20. Rothe G, Gabriel H, Kovacs E, Klucken J, Stohr J, Kindermann W, Schmitz G. Peripheral blood mononuclear phagocyte subpopulations as cellular markers in hypercholesterolemia. Arterioscler Thromb Vasc Biol. 1996;16:1437-1447. (Pubitemid 26427596)
21. Forsythe LK, Wallace JM, Livingstone MB. Obesity and inflammation: the effects of weight loss. Nutr Res Rev. 2008;21:117-133.
22. Poitou C, Coussieu C, Rouault C, Coupaye M, Cancello R, Bedel JF, Gouillon M, Bouillot JL, Oppert JM, Basdevant A, Clement K. Serum amyloid A: a marker of adiposity-induced low-grade inflammation but not of metabolic status. Obesity (Silver Spring). 2006;14:309-318. (Pubitemid 46214763)
23. Kong LC, Hajduch F, Wuillemin PH, Bastard JP, Fellahi S, Bonnefont-Rousselot D, Bittar JD, Basdevant A, Zucker JD, Doré J, Clément K, Rizkalla S. Plasma Insulin and inflammatory markers prior to weight loss can predict dietary responders American Diabetes Association's 71st Scientific Sessions. San Diego, California; 2010.
24. Wallace TM, Levy JC, Matthews DR. Use and abuse of HOMA modeling. Diabetes Care 2004;27:1487-1495. (Pubitemid 38680001)
25. Tsujioka H, Imanishi T, Ikejima H, Kuroi A, Takarada S, Tanimoto T, Kitabata H, Okochi K, Arita Y, Ishibashi K, Komukai K, Kataiwa H, Nakamura N, Hirata K, Tanaka A, Akasaka T. Impact of heterogeneity of human peripheral blood monocyte subsets on myocardial salvage in patients with primary acute myocardial infarction. J Am Coll Cardiol. 2009;54:130-138.
26. Wildgruber M, Lee H, Chudnovskiy A, Yoon TJ, Etzrodt M, Pittet MJ, Nahrendorf M, Croce K, Libby P, Weissleder R, Swirski FK. Monocyte subset dynamics in human atherosclerosis can be profiled with magnetic nano-sensors. PLoS One. 2009;4:e5663.
27. Imanishi T, Ikejima H, Tsujioka H, Kuroi A, Ishibashi K, Komukai K, Tanimoto T, Ino Y, Takeshita T, Akasaka T. Association of monocyte subset counts with coronary fibrous cap thickness in patients with unstable angina pectoris. Atherosclerosis. 2010;212:628-635.
28. Ghanim H, Aljada A, Hofmeyer D, Syed T, Mohanty P, Dandona P. Circulating mononuclear cells in the obese are in a proinflammatory state. Circulation. 2004;110:1564-1571. (Pubitemid 39297977)
29. Nijhuis J, Rensen SS, Slaats Y, van Dielen FM, Buurman WA, Greve JW. Neutrophil activation in morbid obesity, chronic activation of acute inflammation. Obesity (Silver Spring). 2009;17:2014-2018.
30. Sheu WH, Chang TM, Lee WJ, Ou HC, Wu CM, Tseng LN, Lang HF, Wu CS, Wan CJ, Lee IT. Effect of weight loss on proinflammatory state of mononuclear cells in obese women. Obesity (Silver Spring). 2008;16:1033-1038. (Pubitemid 351620479)
31. Kant P, Hull M. Effect of weight loss on proinflammatory state of mononuclear cells in obese women. Obesity (Silver Spring). 2009;17:934; author reply 934-935.
32. Dalmas E, Clement K, Guerre-Millo M. Defining macrophage phenotype and function in adipose tissue. Trends in Immunology. 2011;32:307-314.
33. Di Gregorio GB, Yao-Borengasser A, Rasouli N, Varma V, Lu T, Miles LM, Ranganathan G, Peterson CA, McGehee RE, Kern PA. Expression of CD68 and macrophage chemoattractant protein-1 genes in human adipose and muscle tissues: association with cytokine expression, insulin resistance, and reduction by pioglitazone. Diabetes. 2005;54:2305-2313. (Pubitemid 41134256)
34. Makkonen J, Westerbacka J, Kolak M, Sutinen J, Corner A, Hamsten A, Fisher RM, Yki-Jarvinen H. Increased expression of the macrophage markers and of 11beta-HSD-1 in subcutaneous adipose tissue, but not in cultured monocyte-derived macrophages, is associated with liver fat in human obesity. Int J Obes (Lond). 2007;31:1617-1625. (Pubitemid 47482653)
35. Harman-Boehm I, Bluher M, Redel H, Sion-Vardy N, Ovadia S, Avinoach E, Shai I, Kloting N, Stumvoll M, Bashan N, Rudich A. Macrophage infiltration into omental versus subcutaneous fat across different populations: effect of regional adiposity and the comorbidities of obesity. J Clin Endocrinol Metab. 2007;92:2240-2247. (Pubitemid 46997129)
36. Apovian CM, Bigornia S, Mott M, Meyers MR, Ulloor J, Gagua M, McDonnell M, Hess D, Joseph L, Gokce N. Adipose macrophage infiltration is associated with insulin resistance and vascular endothelial dysfunction in obese subjects. Arterioscler Thromb Vasc Biol. 2008;28:1654-1659.
37. Cancello R, Clement K. Is obesity an inflammatory illness? Role of low-grade inflammation and macrophage infiltration in human white adipose tissue. BJOG. 2006;113:1141-1147. (Pubitemid 44401207)
38. Tordjman J, Poitou C, Hugol D, Bouillot JL, Basdevant A, Bedossa P, Guerre-Millo M, Clement K. Association between omental adipose tissue macrophages and liver histopathology in morbid obesity: influence of glycemic status. J Hepatol. 2009;51:354-362.
39. Cancello R, Henegar C, Viguerie N, Taleb S, Poitou C, Rouault C, Coupaye M, Pelloux V, Hugol D, Bouillot JL, Bouloumie A, Barbatelli G, Cinti S, Svensson PA, Barsh GS, Zucker JD, Basdevant A, Langin D, Clement K. Reduction of macrophage infiltration and chemoattractant gene expression changes in white adipose tissue of morbidly obese subjects after surgery-induced weight loss. Diabetes. 2005;54:2277-2286. (Pubitemid 41134253)
40. Tam CS, Viardot A, Clement K, Tordjman J, Tonks K, Greenfield JR, Campbell LV, Samocha-Bonet D, Heilbronn LK. Short-term overfeeding may induce peripheral insulin resistance without altering subcutaneous adipose tissue macrophages in humans. Diabetes. 2010;59:2164-2170.