A preclinical rodent model of radiation-induced lung injury for medical countermeasure screening in accordance with the FDA animal rule

Health Physics

Volumn 103, Issue 4, 2012, Pages 463-473

  Jackson, Isabel L ^a   Xu, Puting ^b   Hadley, Caroline ^b   Katz, Barry P ^c   McGurk, Ross ^b   Down, Julian D ^d   Vujaskovic, Zeljko ^a,b  

^a UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

^b DUKE UNIVERSITY   (United States)

^c INDIANA UNIVERSITY   (United States)

^d MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

lungs rodent; modeling dose assessment; radiation damage; radiation medical

Indexed keywords

ACUTE RADIATION SYNDROME; ANIMAL; ANIMAL RIGHTS; ARTICLE; C57BL MOUSE; FEMALE; FOOD AND DRUG ADMINISTRATION; HUMAN; LD 50; MALE; MASS SCREENING; METHODOLOGY; MOUSE; PATHOPHYSIOLOGY; RADIATION DOSE; RADIATION INJURY; RADIATION PNEUMONIA; RADIATION PROTECTION; RADIATION RESPONSE; SPECIES DIFFERENCE; SURVIVAL; SURVIVAL RATE; UNITED STATES; WHOLE BODY RADIATION;

ACUTE RADIATION SYNDROME; ANIMAL RIGHTS; ANIMALS; DOSE-RESPONSE RELATIONSHIP, RADIATION; FEMALE; HUMANS; LETHAL DOSE 50; MALE; MASS SCREENING; MICE; MICE, INBRED C57BL; RADIATION DOSAGE; RADIATION INJURIES, EXPERIMENTAL; RADIATION PNEUMONITIS; RADIATION PROTECTION; SPECIES SPECIFICITY; SURVIVAL ANALYSIS; SURVIVAL RATE; UNITED STATES; UNITED STATES FOOD AND DRUG ADMINISTRATION; WHOLE-BODY IRRADIATION;

ANIMALIA; MURINAE; MUS; RODENTIA;

EID: 84866047146     PISSN: 00179078     EISSN: None     Source Type: Journal    
DOI: 10.1097/HP.0b013e31826386ef     Document Type: Article

References (30)

1. Ashcroft T, Simpson JM, Timbrell V. Simple method of estimating severity of pulmonary fibrosis on a numerical scale. J Clin Pathol 41:467-470; 1988.
2. Bates JH, Irvin CG. Measuring lung function in mice: the phenotyping uncertainty principle. J Applied Physiol 94: 1297-1306; 2003.
3. Di Carlo AL, Jackson IL, Shah JR, Czarniecki CW, Maidment B, Williams JP. Development and licensure of medical countermeasures to treat lung damage resulting from a radiological or nuclear incident. Radiat Res 177:717-721; 2012.
4. Dodd-O JM, Hristopoulos ML,Welsh-Servinsky LE, Tankersley CG, Pearse DB. Strain-specific differences in sensitivity to ischemia-reperfusion lung injury in mice. J Applied Physiol 100:1590-1595; 2006.
5. Down JD. The nature and relevance of late lung pathology following localised irradiation of the thorax in mice and rats. British J Cancer 7(Suppl):330-332; 1986.
6. Down JD, Steel GG. The expression of early and late damage after thoracic irradiation: a comparison between CBA and C57B1 mice. Radiat Res 96:603-610; 1983.
7. Down JD, Laurent GJ, Mcanulty RJ, Steel GG. Oxygendependent protection of radiation lung damage in mice by WR 2721. International J Radiat Biol Phys Chem Med 46: 597-607; 1984.
8. Ford JG, Rennick D, Donaldson DD, Venkayya R, Mcarthur C, Hansell E, Kurup VP, Warnock M, Grunig G. Il-13 and IFNgamma: interactions in lung inflammation. J Immunol 167: 1769-1777; 2001.
9. Fryer CJ, Fitzpatrick PJ, Rider WD, Poon P. Radiation pneumonitis: experience following a large single dose of radiation. International J Radiat Oncol Biol Phys 4:931-936; 1978.
10. Gauter-Fleckenstein B, Fleckenstein K, Owzar K, Jiang C, Batinic-Haberle I, Vujaskovic Z. Comparison of two Mn porphyrin-based mimics of superoxide dismutase in pulmonary radioprotection.FreeRadicalBiolMed 44:982-989; 2008.
11. Gross NJ. Pulmonary effects of radiation therapy. Annals Internal Med 86:81-92; 1977.
12. Gueders MM, Paulissen G, Crahay C, Quesada-Calvo F, Hacha J, Van Hove C, Tournoy K, Louis R, Foidart JM, Noel A, Cataldo DD. Mouse models of asthma: a comparison between C57BL/6 and BALB/c strains regarding bronchial responsiveness, inflammation, and cytokine production. Inflammation Res: Official J European HistamineRes Soc 58:845-854; 2009.
13. Hopewell JW, Rezvani M, Moustafa HF. The pig as a model for the study of radiation effects on the lung. International J Radiat Biol 76:447-452; 2000.
14. Hoyt R, Hawkins J, St. Clair M, Kennett M. Mouse physiology. In: Fox J, Barthold S, Davisson M, Newcomer C, Quimby F, Smith A, eds. The mouse in biomedical research: diseases. Burlington: Elsevier; Vol. III. Normative biology, husbandry, and models; 23-90; 2007.
15. Jackson IL, Vujaskovic Z, Down JD. Revisiting strain-related differences in radiation sensitivity of the mouse lung: recognizing and avoiding the confounding effects of pleural effusions. Radiat Res 173:10-20; 2010.
16. Jackson IL, Vujaskovic Z, Down JD. A further comparison of pathologies after thoracic irradiation among different mouse strains: finding the best preclinical model for evaluating therapies directed against radiation-induced lung damage. Radiation Res 175:510-518; 2011.
17. Lomask M. Further exploration of the Penh parameter. Experimental Toxicologic Pathol: Official J Gesellschaft fur Toxikologische Pathologie 57(Suppl 2):13-20; 2006.
18. Lundblad LK, Irvin CG, Adler A, Bates JH. A reevaluation of the validity of unrestrained plethysmography in mice. J Applied Physiol 93:1198-1207; 2002.
19. Marks LB, Fan M, Clough R, Munley M, Bentel G, Coleman RE, Jaszczak R, Hollis D, Anscher M. Radiation-induced pulmonary injury: symptomatic versus subclinical endpoints. International J Radiat Biol 76:469-475; 2000.
20. McGurk R, Hadley C, Jackson IL, Vujaskovic Z. Development and dosimetry of a small animal irradiation platform. Health Phys 103(4):454-462; 2012.
21. Mestas J, Hughes CC. Of mice and not men: differences between mouse and human immunology. J Immunol 172: 2731-2738; 2004.
22. Morris JA, Gardner MJ. Calculating confidence intervals for relative risks (odds ratios) and standardised ratios and rates. British Med J 296:1313-1316; 1988.
23. Rivera J, Tessarollo L. Genetic background and the dilemma of translating mouse studies to humans. Immunity 28:1-4; 2008.
24. Sharplin J, Franko AJ. A quantitative histological study of straindependent differences in the effects of irradiation on mouse lung during the early phase. Radiat Res 119:1-14; 1989a.
25. Sharplin J, Franko AJ. A quantitative histological study of straindependent differences in the effects of irradiation on mouse lung during the intermediate and late phases. Radiat Res 119: 15-31; 1989b.
26. Tankersley CG, Rabold R, Mitzner W. Differential lung mechanics are genetically determined in inbred murine strains. J Applied Physiol 86:1764-1769; 1999.
27. Travis EL, Down JD, Holmes SJ, Hobson B. Radiation pneumonitis and fibrosis in mouse lung assayed by respiratory frequency and histology. Radiat Res 84:133-143; 1980.
28. Travis EL, Tucker SL. The relationship between functional assays of radiation response in the lung and target cell depletion. British J Cancer 7(Suppl):304-319; 1986.
29. Van Dyk J, Keane TJ, Kan S, Rider WD, Fryer CJ. Radiation pneumonitis following large single dose irradiation: a reevaluation based on absolute dose to lung. International J Radiat Oncol Biol Phys 7:461-467; 1981.
30. Williams JP, Brown SL, Georges GE, Hauer-Jensen M, Hill RP, HuserAK,KirschDG,MacvittieTJ,MasonKA,MedhoraMM, Moulder JE, Okunieff P, Otterson MF, Robbins ME, Smathers JB,McbrideWH. Animal models for medical countermeasures to radiation exposure. Radiation Res 173:557-578; 2010.