Monitoring photosensitizer uptake using two photon fluorescence life-time imaging microscopy

Theranostics

Volumn 2, Issue 9, 2012, Pages 817-826

  Allison Yeh, Shu Chi ^a   Diamond, Kevin R ^a   Patterson, Michael S ^a   Nie, Zhaojun ^a   Hayward, Joseph E ^a   Fang, Qiyin ^a  

^a MCMASTER UNIVERSITY   (Canada)

Author keywords

Fluorescence lifetime imaging microscopy (FLIM); Photodynamic therapy (PDT); Photofrin; Segmentation

Indexed keywords

PHOTOFRIN;

ANIMAL CELL; ARTICLE; CELL MEMBRANE; CONTROLLED STUDY; CYTOPLASM; DRUG DISTRIBUTION; DRUG UPTAKE; FLUORESCENCE MICROSCOPY; LIFESPAN; LIGHT ABSORPTION; LIGHT SCATTERING; MALE; MITOCHONDRION; NONHUMAN; PHOTODYNAMIC THERAPY; RAT;

EID: 84866044875     PISSN: None     EISSN: 18387640     Source Type: Journal    
DOI: 10.7150/thno.4479     Document Type: Article

References (34)

1. Wilson BC, Patterson MS. The physics, biophysics and technology of photodynamic therapy. Phys Med Biol.2008; 53:R61-109.
2. Wilson BC, Patterson MS, and Lilge L. Implicit and Explicit Dosimetry in Photodynamic Therapy: a New Paradigm. Laser Med Sci. 1997;3:182-99.
3. Wilson BC, Patterson MS. The physics of photodynamic therapy. Phys Med Biol. 1986;31:327-60.
4. Dysart JS, Patterson MS, Farrell TJ, et al. Relationship between mTHPC fluorescence photobleaching and cell viability during in vitro photody-namic treatment of DP16 cells. Photochem Photobiol. 2002;75:289-95.
5. Dysart JS, Patterson MS. Characterization of Photofrin photobleaching for singlet oxygen dose estimation during photodynamic therapy of MLL cells in vitro. Phys Med Biol. 2005;50:2597-616.
6. Sheng C, Hoopes PJ, Hasan T, et al. Photobleaching-based dosimetry predicts deposited dose in ALA-PpIX PDT of rodent esophagus. Photo-chem Photobiol. 2007;83:738-48.
7. Georgakoudi I, Foster TH. Singlet oxygen- versus nonsinglet oxy-gen-mediated mechanisms of sensitizer photobleaching and their effects on photodynamic dosimetry. Photochem Photobiol. 1998;67:612-25.
8. Diamond KR, Patterson MS, Farrell TJ. Quantification of fluorophore concentration in tissue-simulating media by fluorescence measurements with a single optical fiber. App Opt. 2003;42:2436-42.
9. Cormier JF, Fortin M, Fréchette J, et al. The effects of self-absorption and detection geometry on fluorescence intensity and decay lifetime. Proc SPIE. 2005;5702:123.
10. Diamond KR, Pawel PM, Hayward JE, et al. Quantification of fluoro-phore concentration in vivo using two simple fluorescence-based meas-urement techniques. J Biomed Opt. 2005;10:024007-1-10
11. Suhling K, French PMW, Phillips D. Time-resolved fluorescence mi-croscopy. Photochem Photobiol Sci. 2005;4:13-22.
12. Rueck A. FLIM and SLIM for molecular imaging in PDT. Proc SPIE. 2005;5700:182-7
13. Rueck A, Huelshoff CH, Kinzler I, et al. SLIM: A New Method for Mo-lecular Imaging. Microsc Res Techniq. 2007;492:485-92.
14. Russell JA, Diamond KR, Collins TJ, et al. Characterization of Fluores-cence Lifetime of Photofrin and Delta-Aminolevulinic Acid Induced Protoporphyrin IX in Living Cells Using Two-Photon Excitation. IEEE J Quantum Elect. 2008;14:158-66.
15. Connelly JP, Botchway SW, Kunz L, et al. Time-resolved fluorescence imaging of photosensitiser distributions in mammalian cells using a pi-cosecond laser line-scanning microscope. J Photochem Photobiol A Chem. 2001;142:169-75
16. Koenig K, Wabnitz H, Dietel W. Variation in the fluorescence decay properties of haematoporphyrin derivative during its conversion to photoproducts. J Photochem Photobiol B Biol. 1990;8:103-11.
17. Lassalle H-P, Wagner M, Bezdetnaya L, et al. Fluorescence imaging of Foscan and Foslip in the plasma membrane and in whole cells. J Photo-chem Photobiol B Biol. 2008;92:47-53.
18. Saczko J, Mazurkiewicz M, Chwiłkowska A, et al. Intracellular distribu-tion of Photofrin in malignant and normal endothelial cell lines. Folia Biol. 2007;53:7-12
19. Morgan J, Oseroff AR. Mitochondria-based photodynamic anti-cancer therapy. Adv Drug Delv Rev. 2001;49:71-86.
20. Hilf R. Mitochondria are targets of photodynamic therapy. J Bioenerg Biomembr. 2007;39:85-9.
21. Hsieh Y-J, Wu C-C, Chang C-J, et al. Subcellular localization of Photofrin determines the death phenotype of human epidermoid carcinoma A431 cells triggered by photodynamic therapy: when plasma membranes are the main targets. J Cell Physiol. 2003;194:363-75.
22. Karotki A, Khurana M, Lepock JR, et al. Simultaneous two-photon excitation of photofrin in relation to photodynamic therapy. Photochem Photobiol. 2006;82:443-52.
23. Zipfel WR, Williams RM, Webb WW. Nonlinear magic: multiphoton microscopy in the biosciences. Nat Biotechnol. 2003; 21:1369-77.
24. Oleinick NL, Morris RL, Belichenko I. The role of apoptosis in response to photodynamic therapy: what, where, why, and how. Photochem Photobiol Sci. 2002;1:1-21
25. Morgan J, Potter WR, Oseroff a R. Comparison of photodynamic targets in a carcinoma cell line and its mitochondrial DNA-deficient derivative. Photochem Photobiol. 2000;71:747-57.
26. Schneckenburger H, Steiner R, Rueck A. In vivo photoproduct formation during PDT with ALA-induced endogenous porphyrins. J Photochem Photobiol B: Biol. 1993;18:287-90.
27. Koenig K, and Schneckenburger H. Laser-induced autofluorescence for medical diagnosis. J Fluoresc. 1994;4:17-40
28. Singh G, Jeeves WP, Wilson BC, et al. Mitochondrial photosensitization by Photofrin II. Photochem Photobiol. 1987;46:645-9.
29. Khurana M, Collins HA, Karotki A, et al. Quantitative in vitro demon-stration of two-photon photodynamic therapy using photofrin and visudyne. Photochem Photobiol. 2007;83:1441-8.
30. Levitt JM, Baldwin A, Papadakis A, et al. Intrinsic fluorescence and redox changes associated with apoptosis of primary human epithelial cells. J Biomed Opt. 2006;11:064012-1-10
31. Dittmar R, Petier E, Zandvoort M, et al. Assessment of cell viability in three-dimensional scaffolds using cellular auto-fluorescence. Tissue Eng Pt C-Meth. 2012;18:198-204
32. Kessel D, Luo Y, Deng Y, et al. The role of subcellular localization in initiation of apoptosis by photodynamic therapy. Photochem Photobiol. 1997;65:422-426.
33. Biesele JJ, Goldhaber P. A study of cytoplasmic lipid granularity in tissue culture cells. Cancer Res. 1955;15:767-73.
34. Kabe Y, Ohmori M, Shinouchi K, et al. Porphyrin accumulation in mi-tochondria is mediated by 2-oxoglutarate carrier. J Biol Chem. 2006; 281:31729-35.