Can cyclo-oxygenase-2 be a useful prognostic and risk stratification marker in breast cancer?

Journal of the Indian Medical Association

Volumn 110, Issue 7, 2012, Pages 429-433

  Jana, Debarshi ^a,b   Sarkar, Diptendra Kumar ^a   Maji, Abhiram ^a,c   Chikkala, Bhargava Ram ^a   Hassanujjaman, Syed ^a   Mukhopadhyay, Madhumita ^a   Ganguly, Subhro ^a  

^a SRF   (India)

^b Natl Comm Breast Cancer S

^c Murshidabad Medical College and Hospital   (India)

Author keywords

Breast cancer; Cyclo oxygenase 2 (COX 2); Prognostic marker

Indexed keywords

CYCLOOXYGENASE 2; EPIDERMAL GROWTH FACTOR RECEPTOR 2; ESTROGEN RECEPTOR;

ARTICLE; BREAST CARCINOMA; CANCER RISK; CONTROLLED STUDY; CORRELATION ANALYSIS; FEMALE; HISTOPATHOLOGY; HUMAN; LYMPH NODE METASTASIS; MAJOR CLINICAL STUDY; PHENOTYPE; PROGNOSIS; PROTEIN EXPRESSION; TUMOR VOLUME;

EID: 84866002842     PISSN: 00195847     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (26)

1. Chowa LW, Yip AY, Loo WT, Lam CK, Toi M - Celecoxib anti-aromatase neoadjuvant (CAAN) trial for locally advanced breast cancer cancer. J Steroid Biochem Mol Biol 2008; 111: 13-7.
2. Williams CS, Mann M, Dubois RN - The role of cyclooxygenases in inflammation, cancer, and development. Oncogene 1999; 18: 7908-16.
3. Boland GP, Butt IS, Prasad R, Knox WF, Bundred NJ - COX-2 expression is associated with an aggressive phenotype in ductal carcinoma in situ. Br J Cancer 2004; 90: 423-9.
4. Zhao Y, Agarwal VR, Mendelson CR, Simpson ER - Estrogen biosynthesis proximal to a breast tumor is stimulated by PGE(2) via cyclic AMP, reading to activation of promoter II of the CYP19 (aromatase) gene. Endocrinology 1996; 137: 5739-42.
5. Witton CJ, Hawe SJK, Cooke TG, Bartlett JMS - Cyclooxygenase 2 (COX2) expression is associated with poor outcome in ER-negative, but not ER-positive, breast cancer. Histopathology 2004; 45: 47-54.
6. Tsujii M, Kawano S, Tsuji S, Sawaoka H, Hori M, Dubois RN - Cyclooxygenase regulates angiogenesis induced by colon cancer cells. Cell 1998; 93: 705-16.
7. Subbaramaiah K, Norton L, Gerald W, Dannenberg AJ - Cyclooxygenase- 2 is overexpressed in HER-2/neu-positive breast cancer-evidence for involvement of AP-1 and PEA3. J Biol Chem 2002; 277: 18649-57.
8. Bartlett JMS, Mallon EA, Cooke TG - The clinical evaluation of HER2 status, which test to use? J Pathol 2003; 199: 411-7.
9. Vadlamudi R, Mandal M, Adam L, Steibach G, Mendelsohn J, Kumar R - Regulation of cyclooxygenase-2 pathway by HER2 receptor. Oncogene 1999; 18: 305-14.
10. Half E, Tang XM, Gwyn K, Sahin A, Wathen K, Sinicrope FA - Cyclooxygenase-2 expression in human breast cancers and adjacent ductal carcinoma in situ. Cancer Res 2002; 62: 1676-81.
11. Costa C, Soares R, Reis-Filho JS, Leitão D, Amendoeira I, Schmitt FC - Cyclo-oxygenase 2 expression is associated with angiogenesis and lymph node metastasis in human breast cancer. J Clin Pathol 2002; 55: 429-34.
12. Ciris IM, Bozkurt KK, Baspinar S, Kapucuoglu FM - Immunohistochemical COX-2 overexpression correlates with HER- 2/neu overexpression in invasive breast carcinomas: a pilot study. Pathol Res Pract 2011; 207: 182-7
13. Ristimaki A, Sivula A, Lundin J, Lundin M, Salminen T, Haglund C, et al - Prognostic significance of elevated cyclooxygenase-2 expression in breast cancer. Cancer Res 2002; 62: 632-5
14. Perrone G, Santini D, Vincenzi B, Zagami M, La Cesa A, Bianchi A, et al - COX-2 expression in DCIS: correlation with VEGF, HER-2 neu, prognostic molecular markers and clinicopathological features. Histopathology 2005; 46: 561-8
15. Shim JY, An HJ, Lee YH, Kim SK - Overexpression of cyclooxygenase-2 is associated with breast carcinoma and its poor prognostic factors. Mod Pathol 2003; 16: 1199-204.
16. Soslow RA, Dannenberg AJ, Rush D, Woerner BM, Khan KN, Masferrer J, et al - COX-2 is expressed in human pulmonary, colonic, and mammary tumors. Cancer 2000; 89: 2637-45.
17. Watanabe O, Shimizu T, Kinoshita J, Utada Y, Okabe T, Kimura K, et al - Expression of cyclooxygenase-2 in malignant and benign breast tumours. Anticancer Res 2003; 23: 3215-21.
18. Zeeneldin AA, Mohamed AM, Abdel HA, Taha FM, Goda IA, AboDeef WT - Survival effects of cyclooxygenase-2 and 12-lypooxygenase in Egyptian women with operable breast cancer. Indian J Cancer 2009; 46: 54-60.
19. Tsutsui S, Ohno S, Murakami S, Hachitanda Y, Oda S - Prognostic value of c-erbB2 expression in breast cancer. J Surg Oncol 2002; 79: 216-23.
20. Nakshatri H, Bhat-Nakshatri P, Martin DA, Goulet RJ Jr, Sledge GW Jr - Constitutive activation of NFkappaB during progression of breast cancer to hormone-independent growth. Mol Cell Biol 1997; 17: 3629-39.
21. Welch DR, Wei LL - Genetic and epigenetic regulation of human breast cancer progression and metastasis. Endocr Relat Cancer 1998; 5: 155-97.
22. Kiley SC, Clark KJ, Goodnough M, Welch DR, Jaken S - Protein kinase C delta involvement in mammary tumor cell metastasis. Cancer Res 1999; 59: 3230-8
23. Gilhooly EM, Rose DP - The association between a mutated ras gene and cyclooxygenase-2 expression in human breast cancer cell lines. Int J Oncol 1999; 15: 267-70.
24. Vojtek AB, Der CJ - Increasing complexity of the RAS signaling pathway. J Biol Chem 1998; 273: 19925-8
25. Richards JA, Petrel TA, Brueggemeier RW - Signaling pathways regulating aromatase and cyclooxygenases in normal and malignant breast cells. J Steroid Biochem Mol Biol 2002; 80: 203-12.
26. Subbaramaiah K, Chung WJ, Dannenberg AJ - Ceramide regulates the transcription of cyclooxygenase-2-evidence for involvement of extracellular signal-regulated kinase c- Jun N-terminal kinase and p38 mitogen-activated protein kinase pathways. J Biol Chem 1998; 273: 32943-9.