Successful allogeneic cord blood transplantation in a patient with Evans syndrome leads to correction of hereditary angioedema type i as secondary effect

Bone Marrow Transplantation

Volumn 47, Issue 9, 2012, Pages 1259-1261

  Klausegger, A ^a   Wiednig, M ^b   Urban, C ^c   Lackner, H ^c   Reiter, H ^b   Bauer, J W ^b   Aberer, W ^b  

^a PARACELSUS MEDICAL UNIVERSITY   (Austria)

^b Universitatsklinik fur Dermatologie und Venerologie   (Austria)

^c Universitatsklinik fur Kinder und Jugendheilkunde Graz   (Austria)

Author keywords

[No Author keywords available]

Indexed keywords

ADENINE; COMPLEMENT COMPONENT C1S INHIBITOR; DANAZOL; GUANINE;

ABDOMINAL PAIN; ALLELE; ALLOGENEIC STEM CELL TRANSPLANTATION; AMINO ACID SUBSTITUTION; ANGIONEUROTIC EDEMA; AUTOIMMUNE HEMOLYTIC ANEMIA; BRAIN HEMORRHAGE; CASE REPORT; CHILD; CORD BLOOD STEM CELL TRANSPLANTATION; DISEASE ASSOCIATION; DISEASE SEVERITY; DNA EXTRACTION; DRUG BLOOD LEVEL; ELECTROPHORESIS; GENE SEQUENCE; GENETIC ASSOCIATION; HETEROZYGOSITY; HUMAN; LARYNX EDEMA; LETTER; MALE; MUTATIONAL ANALYSIS; MUTATOR GENE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; SCHOOL CHILD; SERPING1 GENE; SKIN SWELLING; SPLENECTOMY; TREATMENT RESPONSE;

ANEMIA, HEMOLYTIC, AUTOIMMUNE; CHILD; CORD BLOOD STEM CELL TRANSPLANTATION; HEREDITARY ANGIOEDEMA TYPES I AND II; HUMANS; MALE; THROMBOCYTOPENIA; TRANSPLANTATION, HOMOLOGOUS;

EID: 84866002314     PISSN: 02683369     EISSN: 14765365     Source Type: Journal    
DOI: 10.1038/bmt.2012.7     Document Type: Letter

References (9)

1. Agostoni A, Aygoren-Pursun E, Binkley KE, Blanch A, Bork K, Bouillet L et al. Hereditary and acquired angioedema: problems and progress: proceedings of the third C1 esterase inhibitor deficiency workshop and beyond. J Allergy Clin Immunol 2004; 114(3 Suppl): S51-131.
2. Nagy N, Grattan CE, McGrath JA. New insights into hereditary angio-oedema: molecular diagnosis and therapy. Australas J Dermatol 2010; 51: 157-162.
3. Evans RS, Takahashi K, Duane RT, Payne R, Liu CK. Primary thrombocytopenic purpura and acquired hemolytic anemia-evidence for a common etiology. Ama Arch Neurol Psychiatry 1951; 87: 48-65.
4. Benesch M, Urban C, Platzbecker U, Passweg J. Stem cell transplantation for patients with Evans syndrome. Expert Rev Clin Immunol 2009; 5: 341-348.
5. Urban C, Lackner H, Sovinz P, Benesch M, Schwinger W, Dornbusch HJ et al. Successful unrelated cord blood transplantation in a 7-year-old boy with Evans syndrome refractory to immunosuppression and double autologous stem cell transplantation. Eur J Haematol 2006; 76: 526-530.
6. Daikeler T, Hugle T, Farge D, Andolina M, Gualandi F, Baldomero H et al. Allogeneic hematopoietic SCT for patients with autoimmune diseases. Bone Marrow Transplant 2009; 44: 27-33.
7. Kiss TL, Messner HA, Galal A, Lipton J. Correction of recurrent angioedema related to C1 esterase inhibitor deficiency as a secondary event following nonmyeloablative allogeneic stem cell transplantation in a patient with myelofibrosis. Bone Marrow Transplant 2005; 35: 213-214. (Pubitemid 40185943)
8. Roche O, Blanch A, Duponchel C, Fontan G, Tosi M, Lopez-Trascasa M. Hereditary anglioedema: the mutation spectrum of SERPING1/C1NH in a large Spanish cohort. Hum Mutat 2005; 26: 135-144. (Pubitemid 41040682)
9. Lappin D, Whaley K. Regulation of C1-inhibitor synthesis by interferons and other agents. Behring Inst Mitt 1989; 84: 180-192. (Pubitemid 19225134)