Successful unrelated cord blood transplantation in a 7-year-old boy with Evans syndrome refractory to immunosuppression and double autologous stem cell transplantation

European Journal of Haematology

Volumn 76, Issue 6, 2006, Pages 526-530

  Urban, Christian ^a   Lackner, Herwig ^a   Sovinz, Petra ^a   Benesch, Martin ^a   Schwinger, Wolfgang ^a   Dornbusch, Hans Jürgen ^a   Moser, Andrea ^a  

^a MEDICAL UNIVERSITY OF GRAZ   (Austria)

Author keywords

Cord blood; Evans syndrome; Refractory; Transplantation; Unrelated

Indexed keywords

ALEMTUZUMAB; BUSULFAN; CORTICOSTEROID; CYCLOPHOSPHAMIDE; CYCLOSPORIN A; DANAZOL; ETOPOSIDE; FLUDARABINE; IMMUNOGLOBULIN; IMMUNOSUPPRESSIVE AGENT; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; THIOTEPA; THYMOCYTE ANTIBODY; VINCRISTINE;

ARTICLE; AUTOIMMUNE DISEASE; AUTOIMMUNE HEMOLYTIC ANEMIA; AUTOIMMUNE THROMBOCYTOPENIA; AUTOLOGOUS PERIPHERAL BLOOD STEM CELL TRANSPLANTATION; BLOOD CELL COUNT; BLOOD TRANSFUSION; BRAIN HEMORRHAGE; CASE REPORT; GRAFT VERSUS HOST REACTION; HUMAN; IMMUNOSUPPRESSIVE TREATMENT; LYMPHADENOPATHY; MALE; MUSCLE ATROPHY; PRESCHOOL CHILD; PRIORITY JOURNAL; SPLENECTOMY; SPLENOMEGALY; UMBILICAL CORD BLOOD; VIRUS INFECTION;

ADRENAL CORTEX HORMONES; ANEMIA, HEMOLYTIC, AUTOIMMUNE; CEREBRAL HEMORRHAGE; CHILD, PRESCHOOL; CORD BLOOD STEM CELL TRANSPLANTATION; DANAZOL; DRUG RESISTANCE; FEMALE; HUMANS; IMMUNOGLOBULINS, INTRAVENOUS; IMMUNOSUPPRESSIVE AGENTS; MAGNETIC RESONANCE IMAGING; MALE; PERIPHERAL BLOOD STEM CELL TRANSPLANTATION; PURPURA, THROMBOCYTOPENIC, IDIOPATHIC; REMISSION INDUCTION; SPLENECTOMY; TRANSPLANTATION CONDITIONING; TRANSPLANTATION, AUTOLOGOUS; TRANSPLANTATION, HOMOLOGOUS; VINCRISTINE;

EID: 33646509852     PISSN: 09024441     EISSN: 16000609     Source Type: Journal    
DOI: 10.1111/j.0902-4441.2006.t01-1-EJH2549.x     Document Type: Article

References (20)

1. E vans RS T akahashi K D uane RT P ayne R L ie CK Primary thrombocytopenic purpura and acquired haemolytic anemia: evidence for common etiology Arch Intern Med 1951 87 48 65
2. W ang WC Evans syndrome in childhood: pathophysiology, clinical course and treatment Am J Pediatr Hematol Oncol 1988 10 330 338
3. S avasan S W arrier I R avindranath Y The spectrum of Evans' syndrome Arch Dis Child 1997 77 245 248
4. T eachey DT M anno CS A xsom KM A ndrews T C hoi JK G reenbaum BH M c M ann JM S ullivan KE T ravis SF G rupp SA Unmasking Evans syndrome: T cell phenotype and apoptotic response reveal autoimmune lymphoproliferative syndrome (ALPS) Blood 2004 105 2443 2448
5. M oyo VM S mith D B rodsky I C rilley P J ones RJ B rodsky RA High-dose cyclophosphamide for refractory autoimmune hemolytic anemia Blood 2002 100 704 706
6. J ubinsky PT R ashid N Successful treatment of a patient with mixed warm and cold antibody mediated Evans syndrome and glucose intolerance Pediatr Blood Cancer 2005 44 1 4
7. R aj K N arayanan X A ugustson B H o A M ehta P D uncan N T auro S M ahendra P C raddock C M ufti G Rituximab is effective in the management of refractor autoimmune cytopenias occurring after allogeneic stem cell transplantation Bone Marrow Transplant 2005 35 299 301
8. M armont AM G ualandi F van L int MT B acigalupo A Refractory Evans' syndrome treated with allogeneic SCT followed by DLI. Demonstration of a graft-versus-autoimmunity effect Bone Marrow Transplant 2003 31 399 402
9. S caradavou A B ussel J Evans syndrome. Results of a pilot study utilizing a multiagent treatment protocol J Pediatr Hematol Oncol 1995 17 290 295
10. H uhn RD F ogarty F N akamura R et al High-dose cyclophosphamide with autologous lymphocyte-depleted peripheral blood stem cell (PBSC) support for treatment of refractory chronic autoimmune thrombocytopenia Blood 2003 101 71 77
11. G ural A G illis S G afanovich A I srael Z W olf D P omeranz S B en -Y ehuda D Massive intracranial bleeding requiring emergency splenectomy in a patient with CMV-associated thrombocytopenia Haemostasis 1998 28 250 255
12. 3) due to adolescence-onset idiopathic thrombocytopenic purpura Acta Neurochir 2004 146 199 201
13. P opat U K rance R Haematopoietic stem cell transplantation for autoimmune disorders: the American perspective Br J Haematol 2004 126 637 649
14. P assweg JR R abusin M M usso M et al. for the Autoimmune Disease Working Party of EBMT Haematopoietic stem cell transplantation for refractory autoimmune cytopenia Br J Haematol 2004 125 749 755
15. M armont AM Immune ablation and stem cell transplantation for severe Evans syndrome and refractory thrombocytopenic purpura Bone Marrow Transplant 1999 23 1215 1216
16. S koda RC T ichelli A T yndall A H offmann T G illesser S G ratwohl A Autologous peripheral blood stem cell transplantation in refractory thrombocytopenic purpura Br J Haematol 1997 99 56 57
17. O yama Y P apadopoulos EB M iranda M T raynor AE B urt RK Allogeneic stem cell transplantation for Evans syndrome Bone Marrow Transplant 2001 28 903 905
18. H ough RE S nowden JA W ulffraat N Haemopoietic stem cell transplantation in autoimmune diseases: a European perspective Br J Haematol 2004 128 432 459
19. R aetz E B eatty PG A dams RH Treatment of severe Evans syndrome with an allogeneic cord blood transplant Bone Marrow Transplant 1997 20 427 429
20. S ykes M N ikolic B Treatment of severe autoimmune disease by stem-cell transplantation Nature 2005 620 627