The Crystal Structures of the Tryparedoxin-Tryparedoxin Peroxidase Couple Unveil the Structural Determinants of Leishmania Detoxification Pathway

PLoS Neglected Tropical Diseases

Volumn 6, Issue 8, 2012, Pages

  Fiorillo, Annarita ^a   Colotti, Gianni ^b   Boffi, Alberto ^a,b   Baiocco, Paola ^a   Ilari, Andrea ^b  

^a SAPIENZA UNIVERSITY OF ROME   (Italy)

^b CNR   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

CYSTEINE; DISULFIDE; OLIGOMER; PROTOZOAL PROTEIN; TRYPAREDOXIN; TRYPAREDOXIN PEROXIDASE; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; CRYSTAL STRUCTURE; CRYSTALLIZATION; DETOXIFICATION; DRUG TARGETING; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME CONFORMATION; GEL ELECTROPHORESIS; GEL PERMEATION CHROMATOGRAPHY; LEISHMANIA MAJOR; LEISHMANIASIS; MODEL; PROTEIN PROTEIN INTERACTION; PROTEIN SECONDARY STRUCTURE; PROTEIN STRUCTURE; SEQUENCE ALIGNMENT; STATIC ELECTRICITY; STRUCTURAL BIOINFORMATICS; STRUCTURAL HOMOLOGY; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS; SURFACE CHARGE; SURFACE PLASMON RESONANCE;

AMINO ACID SEQUENCE; CRYSTALLOGRAPHY, X-RAY; HYDROGEN PEROXIDE; LEISHMANIA MAJOR; METABOLIC DETOXICATION, DRUG; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PEROXIDASES; PROTEIN CONFORMATION; PROTEIN MULTIMERIZATION; PROTOZOAN PROTEINS; SEQUENCE ALIGNMENT; STATIC ELECTRICITY; THIOREDOXINS;

EID: 84865996192     PISSN: 19352727     EISSN: 19352735     Source Type: Journal    
DOI: 10.1371/journal.pntd.0001781     Document Type: Article

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