Diagnostic usefulness of genomic breakpoint analysis of various gene rearrangements in acute leukemias: A perspective of long distance- or long distance inverse-PCR-based approaches

Annals of Laboratory Medicine

Volumn 32, Issue 4, 2012, Pages 316-318

  Yang, John Jeongseok ^a   Marschalek, Rolf ^b   Meyer, Claus ^b   Park, Tae Sung ^a  

^a Kyung Hee University Hospital   (South Korea)

^b GOETHE UNIVERSITY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 84865992825     PISSN: 22343806     EISSN: 22343814     Source Type: Journal    
DOI: 10.3343/alm.2012.32.4.316     Document Type: Letter

References (18)

1. Tijo JH and Levan A. The chromosome number of man. Hereditas 1956;42:1-6.
2. Rowley JD. Chromosomal translocations: revisited yet again. Blood 2008;112:2183-9.
3. Chen J, Odenike O, Rowley JD. Leukaemogenesis: more than mutant genes. Nat Rev Cancer 2010;10:23-36.
4. Choi HJ, Kim HR, Shin MG, Kook H, Kim HJ, Shin JH, et al. Spectra of chromosomal aberrations in 325 leukemia patients and implications for the development of new molecular detection systems. J Korean Med Sci 2011;26:886-92.
5. Kim MJ, Choi JR, Suh JT, Lee HJ, Lee WI, Park TS. Diagnostic standardization of leukemia fusion gene detection system using multiplex reverse transcriptase-polymerase chain reaction in Korea. J Korean Med Sci 2011;26:1399-400.
6. Meyer C, Schneider B, Reichel M, Angermueller S, Strehl S, Schnittger S, et al. Diagnostic tool for the identifcation of MLL rearrangements including unknown partner genes. Proc Natl Acad Sci USA 2005;102:449-54. (Pubitemid 40116787)
7. Meyer C, Kowarz E, Hofmann J, Renneville A, Zuna J, Trka J, et al. New insights to the MLL recombinome of acute leukemias. Leukemia 2009;23:1490-9.
8. Lee SG, Park TS, Oh SH, Park JC, Yang YJ, Marschalek R, et al. De novo acute myeloid leukemia associated with t (11;17) (q23;q25) and MLL-SEPT9 rearrangement in an elderly patient: a case study and review of the literature. Acta Haematol 2011;126:195-8.
9. Park TS, Lee ST, Song J, Lee KA, Lee SG, Kim J, et al. MLL rearrangement with t (6;11) (q15;q23) as a sole abnormality in a patient with de novo acute myeloid leukemia: conventional cytogenetics, FISH, and multicolor FISH analyses for detection of rare MLL-related chromosome abnormalities. Cancer Genet Cytogenet 2008;187:50-3.
10. Park TS, Lee SG, Song J, Lee KA, Kim J, Choi JR, et al. CASP8AP2 is a novel partner gene of MLL rearrangement with t (6;11) (q15;q23) in acute myeloid leukemia. Cancer Genet Cytogenet 2009;195:94-5.
11. Lee SG, Park TS, Won SC, Song J, Lee KA, Choi JR, et al. Three-way translocation involving MLL, MLLT1, and a novel third partner, NRXN1, in a patient with acute lymphoblastic leukemia and t (2;19;11) (p12;p13.3; q23). Cancer Genet Cytogenet 2010;197:32-8.
12. Cho SY, Park TS, Oh SH, Cho EH, Oh D, Huh JY, et al. Genomic analysis of a four-way t (4;11;22;10) associated with MLL-AF4 in an adult acute lymphoblastic leukemia. Ann Hematol 2012;91:977-9.
13. Kim MJ, Cho SY, Kim MH, Lee JJ, Kang SY, Cho EH, et al. FISH-negative cryptic PML-RARA rearrangement detected by long-distance polymerase chain reaction and sequencing analyses: a case study and review of the literature. Cancer Genet Cytogenet 2010;203:278-83.
14. Lim G, Cho EH, Cho SY, Shin SY, Park JC, Yang YJ, et al. A novel PML-ADAMTS17-RARA gene rearrangement in a patient with pregnancy-related acute promyelocytic leukemia. Leuk Res 2011;35:e106-10.
15. Yang JJ, Park TS, Choi JR, Park SJ, Cho SY, Jun. KR, et al. Submicroscopic deletion of FGFR1 gene is recurrently detected in myeloid and lymphoid neoplasms associated with ZMYM2-FGFR1 rearrangements: a case study. Acta Haematol 2012;127:119-23.
16. Meyer C, Brieger A, Plotz G, Weber N, Passmann S, Dingermann T, et al. An interstitial deletion at 3p21.3 results in the genetic fusion of MLH1 and ITGA9 in a Lynch syndrome family. Clin Cancer Res 2009;15:762-9.
17. Cin H, Meyer C, Herr R, Janzarik WG, Lambert S, Jones DT, et al. Oncogenic FAM131B-BRAF fusion resulting from 7q34 deletion comprises an alternative mechanism of MAPK pathway activation in pilocytic astrocytoma. Acta Neuropathol 2011;121:763-74.
18. Burmeister T, Marschalek R, Schneider B, Meyer C, Gökbuget N, Schwartz S, et al. Monitoring minimal residual disease by quantifcation of genomic chromosomal breakpoint sequences in acute leukemias with MLL aberrations. Leukemia 2006;20:451-7. (Pubitemid 43291743)