CASP8AP2 is a novel partner gene of MLL rearrangement with t(6;11)(q15;q23) in acute myeloid leukemia

Cancer Genetics and Cytogenetics

Volumn 195, Issue 1, 2009, Pages 94-95

  Park, Tae Sung ^a   Lee, Sang Guk ^b   Song, Jaewoo ^b   Lee, Kyung A ^b   Kim, Juwon ^b   Choi, Jong Rak ^b   Lee, Seung Tae ^b   Marschalek, Rolf ^c   Meyer, Claus ^c  

^a Kyung Hee University Hospital   (South Korea)

^b Yonsei University College of Medicine   (South Korea)

^c ZAFES   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEMENTARY DNA; GENE PRODUCT; GENOMIC DNA; MESSENGER RNA; MIXED LINEAGE LEUKEMIA PROTEIN; PROTEIN CASP8AP2; UNCLASSIFIED DRUG;

ACUTE GRANULOCYTIC LEUKEMIA; ADULT; APOPTOSIS; CANCER SURVIVAL; CASE REPORT; CHROMOSOME 6Q; CHROMOSOME DELETION; CHROMOSOME TRANSLOCATION 6; DNA DETERMINATION; DNA SEQUENCE; FEMALE; GENE DELETION; GENE EXPRESSION REGULATION; GENE FUSION; GENE REARRANGEMENT; HUMAN; HUMAN CELL; INTRON; LETTER; PRIORITY JOURNAL; PROGNOSIS;

APOPTOSIS REGULATORY PROTEINS; BASE SEQUENCE; CALCIUM-BINDING PROTEINS; CHROMOSOMES, HUMAN, PAIR 11; CHROMOSOMES, HUMAN, PAIR 6; GENE REARRANGEMENT; HUMANS; LEUKEMIA, MYELOID, ACUTE; MOLECULAR SEQUENCE DATA; MYELOID-LYMPHOID LEUKEMIA PROTEIN; TRANSLOCATION, GENETIC;

EID: 70349855205     PISSN: 01654608     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cancergencyto.2009.06.023     Document Type: Letter

References (10)

1. Meyer C., Kowarz E., Hofmann J., Renneville A., Zuna J., Trka J., Ben Abdelali R., Macintyre E., De Braekeleer E., De Braekeleer M., Delabesse E., de Oliveira M.P., Cavé H., Clappier E., van Dongen J.J., Balgobind B.V., van den Heuvel-Eibrink M.M., Beverloo H.B., Panzer-Grümayer R., Teigler-Schlegel A., Harbott J., Kjeldsen E., Schnittger S., Koehl U., Gruhn B., Heidenreich O., Chan L.C., Yip S.F., Krzywinski M., Eckert C., Möricke A., Schrappe M., Alonso C.N., Schäfer B.W., Krauter J., Lee D.A., Zur Stadt U., Te Kronnie G., Sutton R., Izraeli S., Trakhtenbrot L., Lo Nigro L., Tsaur G., Fechina L., Szczepanski T., Strehl S., Ilencikova D., Molkentin M., Burmeister T., Dingermann T., Klingebiel T., and Marschalek R. New insights to the MLL recombinome of acute leukemias. Leukemia 23 (2009) 1490-1499
2. Park T.S., Lee S.T., Song J., Lee K.A., Lee S.G., Kim J., Suh B., Kim S.J., Lee J.H., Park R., and Choi J.R. MLL rearrangement with t(6;11)(q15;q23) as a sole abnormality in a patient with de novo acute myeloid leukemia: conventional cytogenetics, FISH, and multicolor FISH analyses for detection of rare MLL-related chromosome abnormalities. Cancer Genet Cytogenet 187 (2008) 50-53
3. Meyer C., Schneider B., Reichel M., Angermueller S., Strehl S., Schnittger S., Schoch C., Jansen M.W., van Dongen J.J., Pieters R., Haas O.A., Dingermann T., Klingebiel T., and Marschalek R. Diagnostic tool for the identification of MLL rearrangements including unknown partner genes. Proc Natl Acad Sci U S A 102 (2005) 449-454
4. Meyer C., Schneider B., Jakob S., Strehl S., Attarbaschi A., Schnittger S., Schoch C., Jansen M.W., van Dongen J.J., den Boer M.L., Pieters R., Ennas M.G., Angelucci E., Koehl U., Greil J., and Griesinger F. Zur Stadt U, Eckert C, Szczepański T, Niggli FK, Schäfer BW, Kempski H, Brady HJ, Zuna J, Trka J, Nigro LL, Biondi A, Delabesse E, Macintyre E, Stanulla M, Schrappe M, Haas OA, Burmeister T, Dingermann T, Klingebiel T, Marschalek R. The MLL recombinome of acute leukemias. Leukemia 20 (2006) 777-784
5. Imai Y., Kimura T., Murakami A., Yajima N., Sakamaki K., and Yonehara S. The CED-4-homologous protein FLASH is involved in Fas-mediated activation of caspase-8 during apoptosis [Erratum in: Nature 1999;400:89]. Nature 398 (1999) 777-785
6. Kino T., and Chrousos G.P. Tumor necrosis factor α receptor- and Fas-associated FLASH inhibit transcriptional activity of the glucocorticoid receptor by binding to and interfering with its interaction with p160 type nuclear receptor coactivators. J Biol Chem 278 (2003) 3023-3029
7. Obradović D., Tirard M., Némethy Z., Hirsch O., Gronemeyer H., and Almeida O.F. DAXX, FLASH, and FAF-1 modulate mineralocorticoid and glucocorticoid receptor-mediated transcription in hippocampal cells: toward a basis for the opposite actions elicited by two nuclear receptors?. Mol Pharmacol 65 (2004) 761-769
8. Jun J.I., Chung C.W., Lee H.J., Pyo J.O., Lee K.N., Kim N.S., Kim Y.S., Yoo H.S., Lee T.H., Kim E., and Jung Y.K. Role of FLASH in caspase-8-mediated activation of NF-κB: dominant-negative function of FLASH mutant in NF-κB signaling pathway. Oncogene 24 (2005) 688-696
9. Flotho C., Coustan-Smith E., Pei D., Iwamoto S., Song G., Cheng C., Pui C.H., Downing J.R., and Campana D. Genes contributing to minimal residual disease in childhood acute lymphoblastic leukemia: prognostic significance of CASP8AP2. Blood 108 (2006) 1050-1057
10. Remke M., Pfister S., Kox C., Toedt G., Becker N., Benner A., Werft W., Breit S., Liu S., Engel F., Wittmann A., Zimmermann M., Stanulla M., Schrappe M., Ludwig W.D., Bartram C.R., Radlwimmer B., Muckenthaler M.U., Lichter P., and Kulozik A.E. High-resolution genomic profiling of childhood T-ALL reveals frequent copy-number alterations affecting the TGF-β and PI3 K-AKT pathways and deletions at 6q15-16.1 as a genomic marker for unfavorable early treatment response. Blood 114 (2009) 1053-1062