Genomic analysis of a four-way t(4;11;22;10) associated with MLL-AF4 in an adult acute lymphoblastic leukemia

Annals of Hematology

Volumn 91, Issue 6, 2012, Pages 977-979

  Cho, Sun Young ^a   Park, Tae Sung ^a   Oh, Seung Hwan ^b   Cho, Eun Hae ^c   Oh, Doyeun ^d   Huh, Ji Young ^d   Marschalek, Rolf ^e   Meyer, Claus ^e  

^a Kyung Hee University Hospital   (South Korea)

^b Inje University   (South Korea)

^c Green Cross Reference Laboratory   (South Korea)

^d CHA University   (South Korea)

^e GOETHE UNIVERSITY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; CD19 ANTIGEN; CD22 ANTIGEN; CD34 ANTIGEN; HEMOGLOBIN; MIXED LINEAGE LEUKEMIA PROTEIN;

ACUTE LYMPHOBLASTIC LEUKEMIA; ADULT; AF4 GENE; BONE MARROW; CANCER CHEMOTHERAPY; CASE REPORT; CHROMOSOME TRANSLOCATION 10; CHROMOSOME TRANSLOCATION 11; CHROMOSOME TRANSLOCATION 22; CHROMOSOME TRANSLOCATION 4; EPISTAXIS; FLOW CYTOMETRY; FUSION GENE; GENE REARRANGEMENT; GENETIC ANALYSIS; HUMAN; KARYOTYPE 46,XY; LETTER; LEUKEMIA REMISSION; LEUKOCYTE COUNT; MALE; MLL GENE; PETECHIA; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SKIN BRUISING; THROMBOCYTE COUNT;

ADULT; BASE SEQUENCE; CHROMOSOMES, HUMAN, PAIR 10; CHROMOSOMES, HUMAN, PAIR 11; CHROMOSOMES, HUMAN, PAIR 22; CHROMOSOMES, HUMAN, PAIR 4; CYTOGENETIC ANALYSIS; GENOME, HUMAN; HUMANS; MALE; MOLECULAR SEQUENCE DATA; MYELOID-LYMPHOID LEUKEMIA PROTEIN; ONCOGENE PROTEINS, FUSION; PRECURSOR CELL LYMPHOBLASTIC LEUKEMIA-LYMPHOMA; TRANSLOCATION, GENETIC;

EID: 84862686549     PISSN: 09395555     EISSN: 14320584     Source Type: Journal    
DOI: 10.1007/s00277-011-1364-3     Document Type: Letter

References (13)

1. Meyer C, Kowarz E, Hofmann J, Renneville A, Zuna J, Trka J, Ben Abdelali R, Macintyre E, De Braekeleer E, De Braekeleer M, Delabesse E, de Oliveira MP, Cavé H, Clappier E, van Dongen JJ, Balgobind BV, van den Heuvel-Eibrink MM, Beverloo HB, Panzer-Grümayer R, Teigler-Schlegel A, Harbott J, Kjeldsen E, Schnittger S, Koehl U, Gruhn B, Heidenreich O, Chan LC, Yip SF, Krzywinski M, Eckert C, Möricke A, Schrappe M, Alonso CN, Schäfer BW, Krauter J, Lee DA, Zur Stadt U, Te Kronnie G, Sutton R, Izraeli S, Trakhtenbrot L, Lo Nigro L, Tsaur G, Fechina L, Szczepanski T, Strehl S, Ilencikova D, Molkentin M, Burmeister T, Dingermann T, Klingebiel T, Marschalek R (2009) New insights to the MLL recombinome of acute leukemias. Leukemia 23:1490-1499
2. Chen CS, Sorensen PH, Domer PH, Reaman GH, Korsmeyer SJ, Heerema NA, Hammond GD, Kersey JH (1993) Molecular rearrangements on chromosome 11q23 predominate in infant acute lymphoblastic leukemia and are associated with specific biologic variables and poor outcome. Blood 81:2386-2393 (Pubitemid 23127075)
3. Meyer C, Schneider B, Reichel M, Angermueller S, Strehl S, Schnittger S, Schoch C, Jansen MW, van Dongen JJ, Pieters R, Haas OA, Dingermann T, Klingebiel T, Marschalek R (2005) Diagnostic tool for the identification of MLL rearrangements including unknown partner genes. Proc Natl Acad Sci U S A 102:449-454 (Pubitemid 40116787)
4. Lee SG, Park TS, Won SC, Song J, Lee KA, Choi JR, Marschalek R, Meyer C (2010) Three-way translocation involving MLL, MLLT1, and a novel third partner, NRXN1, in a patient with acute lymphoblastic leukemia and t(2;19;11) (p12;p13. 3;q23). Cancer Genet Cytogenet 197:32-38
5. Kowarz E, Burmeister T, Lo Nigro L, Jansen MW, Delabesse E, Klingebiel T, Dingermann T, Meyer C, Marschalek R (2007) Complex MLL rearrangements in t(4;11) leukemia patients with absent AF4.MLL fusion allele. Leukemia 21:1232-1238 (Pubitemid 46838515)
6. Marschalek R (2011) Mechanisms of leukemogenesis by MLL fusion proteins. Br J Haematol 152:141-154
7. Nilson I, Reichel M, Ennas MG, Greim R, Knörr C, Siegler G, Greil J, Fey GH, Marschalek R (1997) Exon/intron structure of the human AF-4 gene, a member of the AF-4/LAF-4/FMR-2 gene family coding for a nuclear protein with structural alterations in acute leukaemia. Br J Haematol 98:157-169 (Pubitemid 27348811)
8. Løvf M, Thomassen GO, Bakken AC, Celestino R, Fioretos T, Lind GE, Lothe RA, Skotheim RI (2011) Fusion gene microarray reveals cancer type-specificity among fusion genes. Genes Chromosomes Cancer 50:348-357
9. Celetti A, Cerrato A, Merolla F, Vitagliano D, Vecchio G, Grieco M (2004) H4(D10S170), a gene frequently rearranged with RET in papillary thyroid carcinomas: functional characterization. Oncogene 23:109-121 (Pubitemid 38142245)
10. Merolla F, Pentimalli F, Pacelli R, Vecchio G, Fusco A, Grieco M, Celetti A (2007) Involvement of H4(D10S170) protein in ATM dependent response to DNA damage. Oncogene 26:6167-6175 (Pubitemid 47414381)
11. Leone V, Mansueto G, Pierantoni GM, Tornincasa M, Merolla F, Cerrato A, Santoro M, Grieco M, Scaloni A, Celetti A, Fusco A (2010) CCDC6 represses CREB1 activity by recruiting histone deacetylase 1 and protein phosphatase 1. Oncogene 29:4341-4351
12. Mecucci C (2011) t(5;10)(q33;q21). Atlas Genet Cytogenet Oncol Haematol. Available at http://AtlasGeneticsOncology.org/Anomalies/t510ID1166. html
13. Lim G, Cho EH, Cho SY, Shin SY, Park JC, Yang YJ, Oh SH, Marschalek R, Meyer C, Park TS (2011) A novel PMLADAMTS17-RARA gene rearrangement in a patient with pregnancy-related acute promyelocytic leukemia. Leuk Res 35: e106-e110