Effects of valproic acid on the expression of trophic factors in human bone marrow mesenchymal stromal cells

Neuroscience Letters

Volumn 526, Issue 2, 2012, Pages 100-105

  Cho, Goang Won ^b   Kang, Byung Yong ^a   Kim, Kyung Suk ^c   Kim, Seung Hyun ^a  

^a Hanyang University   (South Korea)

^b Chosun University   (South Korea)

^c Division of Dg and Ai Business   (South Korea)

Author keywords

Bone marrow mesenchymal stromal cells (BM MSCs); Migration; Protection; Trophic factors; Valproic acid (VPA)

Indexed keywords

ANGIOGENIC FACTOR; BETA PIX PROTEIN; BRAIN DERIVED NEUROTROPHIC FACTOR; ENDOTHELIAL CELL GROWTH FACTOR; FIBROBLAST GROWTH FACTOR 2; GLIAL CELL LINE DERIVED NEUROTROPHIC FACTOR; PLACENTAL GROWTH FACTOR; PROTEIN; SCATTER FACTOR; TRANSFORMING GROWTH FACTOR BETA1; UNCLASSIFIED DRUG; VALPROIC ACID;

ARTICLE; BONE MARROW CELL; CELL MIGRATION; CELL PROTECTION; CONTROLLED STUDY; GENE EXPRESSION; HUMAN; HUMAN CELL; MESENCHYMAL STROMA CELL; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; STEM CELL TRANSPLANTATION;

BONE MARROW CELLS; CELL PROLIFERATION; CELLS, CULTURED; CHEMOTAXIS; HUMANS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; MESENCHYMAL STROMAL CELLS; NEUROPROTECTIVE AGENTS; OXIDATIVE STRESS; VALPROIC ACID;

EID: 84865990250     PISSN: 03043940     EISSN: 18727972     Source Type: Journal    
DOI: 10.1016/j.neulet.2012.08.015     Document Type: Article

References (26)

1. Caplan A.I. Adult mesenchymal stem cells for tissue engineering versus regenerative medicine. Journal of Cellular Physiology 2007, 213:341-347.
2. Caplan A.I., Dennis J.E. Mesenchymal stem cells as trophic mediators. Journal of Cellular Biochemistry 2006, 98:1076-1084.
3. Chen G., Huang L.D., Jiang Y.M., Manji H.K. The mood-stabilizing agent valproate inhibits the activity of glycogen synthase kinase-3. Journal of Neurochemistry 1999, 72:1327-1330.
4. Chen P.S., Peng G.S., Li G., Yang S., Wu X., Wang C.C., Wilson B., Lu R.B., Gean P.W., Chuang D.M., Hong J.S. Valproate protects dopaminergic neurons in midbrain neuron/glia cultures by stimulating the release of neurotrophic factors from astrocytes. Molecular Psychiatry 2006, 11:1116-1125.
5. Cho G.W., Koh S.H., Kim M.H., Yoo A.R., Noh M.Y., Oh S., Kim S.H. The neuroprotective effect of erythropoietin-transduced human mesenchymal stromal cells in an animal model of ischemic stroke. Brain Research 2010, 1353:1-13.
6. Cho G.W., Noh M.Y., Kim H.Y., Koh S.H., Kim K.S., Kim S.H. Bone marrow-derived stromal cells from amyotrophic lateral sclerosis patients have diminished stem cell capacity. Stem Cells and Development 2010, 19:1035-1042.
7. Choi M.R., Kim H.Y., Park J.Y., Lee T.Y., Baik C.S., Chai Y.G., Jung K.H., Park K.S., Roh W., Kim K.S., Kim S.H. Selection of optimal passage of bone marrow-derived mesenchymal stem cells for stem cell therapy in patients with amyotrophic lateral sclerosis. Neuroscience Letters 2010, 472:94-98.
8. Darras B.T., Kang P.B. Clinical trials in spinal muscular atrophy. Current Opinion in Pediatrics 2007, 19:675-679.
9. Drevets W.C. Neuroimaging studies of mood disorders. Biological Psychiatry 2000, 48:813-829.
10. Heeschen C., Lehmann R., Honold J., Assmus B., Aicher A., Walter D.H., Martin H., Zeiher A.M., Dimmeler S. Profoundly reduced neovascularization capacity of bone marrow mononuclear cells derived from patients with chronic ischemic heart disease. Circulation 2004, 109:1615-1622.
11. Kobune M., Kawano Y., Ito Y., Chiba H., Nakamura K., Tsuda H., Sasaki K., Dehari H., Uchida H., Honmou O., Takahashi S., Bizen A., Takimoto R., Matsunaga T., Kato J., Kato K., Houkin K., Niitsu Y., Hamada H. Telomerized human multipotent mesenchymal cells can differentiate into hematopoietic and cobblestone area-supporting cells. Experimental Hematology 2003, 31:715-722.
12. Koch-Weser J., Browne T.R. Drug therapy: Valproic acid. New England Journal of Medicine 1980, 302:661-666.
13. Koh S.H., Noh M.Y., Cho G.W., Kim K.S., Kim S.H. Erythropoietin increases the motility of human bone marrow-multipotent stromal cells (hBM-MSCs) and enhances the production of neurotrophic factors from hBM-MSCs. Stem Cells and Development 2009, 18:411-421.
14. Lamalice L., Le Boeuf F., Huot J. Endothelial cell migration during angiogenesis. Circulation Research 2007, 100:782-794.
15. Lee S., Park J.R., Seo M.S., Roh K.H., Park S.B., Hwang J.W., Sun B., Seo K., Lee Y.S., Kang S.K., Jung J.W., Kang K.S. Histone deacetylase inhibitors decrease proliferation potential and multilineage differentiation capability of human mesenchymal stem cells. Cell Proliferation 2009, 42:711-720.
16. Miller T.A., Witter D.J., Belvedere S. Histone deacetylase inhibitors. Journal of Medicinal Chemistry 2003, 46:5097-5116.
17. Rajkowska G. Postmortem studies in mood disorders indicate altered numbers of neurons and glial cells. Biological Psychiatry 2000, 48:766-777.
18. Rogawski M.A., Loscher W. The neurobiology of antiepileptic drugs. Nature Reviews Neuroscience 2004, 5:553-564.
19. Rossi D.J., Bryder D., Seita J., Nussenzweig A., Hoeijmakers J., Weissman I.L. Deficiencies in DNA damage repair limit the function of haematopoietic stem cells with age. Nature 2007, 447:725-729.
20. Rossi D.J., Jamieson C.H., Weissman I.L. Stems cells and the pathways to aging and cancer. Cell 2008, 132:681-696.
21. Shahien R., Saleh S.A., Bowirrat A. Intravenous sodium valproate aborts migraine headaches rapidly. Acta Neurologica Scandinavica 2011, 123:257-265.
22. Sharpless N.E., DePinho R.A. Telomeres, stem cells, senescence, and cancer. Journal of Clinical Investigation 2004, 113:160-168.
23. Tsai L.K., Wang Z., Munasinghe J., Leng Y., Leeds P., Chuang D.M. Mesenchymal stem cells primed with valproate and lithium robustly migrate to infarcted regions and facilitate recovery in a stroke model. Stroke 2011, 42:2932-2939.
24. Wagner J., Kean T., Young R., Dennis J.E., Caplan A.I. Optimizing mesenchymal stem cell-based therapeutics. Current Opinion in Biotechnology 2009, 20:531-536.
25. Wu X., Chen P.S., Dallas S., Wilson B., Block M.L., Wang C.C., Kinyamu H., Lu N., Gao X., Leng Y., Chuang D.M., Zhang W., Lu R.B., Hong J.S. Histone deacetylase inhibitors up-regulate astrocyte GDNF and BDNF gene transcription and protect dopaminergic neurons. International Journal of Neuropsychopharmacology 2008, 11:1123-1134.
26. Yasuda S., Liang M.H., Marinova Z., Yahyavi A., Chuang D.M. The mood stabilizers lithium and valproate selectively activate the promoter IV of brain-derived neurotrophic factor in neurons. Molecular Psychiatry 2009, 14:51-59.