Characterization and in-vitro bioactivity evaluation of paclitaxel-loaded polyester nanoparticles

Anti-Cancer Drugs

Volumn 23, Issue 9, 2012, Pages 947-958

  López Gasco, Patricia ^a   Iglesias, Irene ^a   Benedí, Juana ^a   Lozano, Rafael ^a   Blanco, María Dolores ^a  

^a UNIVERSIDAD COMPLUTENSE DE MADRID   (Spain)

Author keywords

biodegradable polymers; cancer; cell culture; controlled release; double emulsion, nanoparticles; paclitaxel

Indexed keywords

NANOPARTICLE; PACLITAXEL; POLYCAPROLACTONE; POLYESTER; POLYGLACTIN; SOLVENT; WATER OIL CREAM;

ARTICLE; BIOCOMPATIBILITY; CELL CYCLE; CELL CYCLE G0 PHASE; CELL CYCLE G1 PHASE; CELL GROWTH; CELL KILLING; CELL STRAIN MCF 7; CELL VIABILITY; CONTROLLED STUDY; CYTOTOXICITY; DRUG DECOMPOSITION; DRUG DEGRADATION; DRUG DELIVERY SYSTEM; DRUG DOSAGE FORM COMPARISON; DRUG FORMULATION; DRUG RELEASE; DRUG SOLUBILITY; DRUG STABILITY; EVAPORATION; FIELD EMISSION SCANNING ELECTRON MICROSCOPY; FLOW CYTOMETRY; FLUORESCENCE MICROSCOPY; G2 PHASE CELL CYCLE CHECKPOINT; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; IN VITRO STUDY; M PHASE CELL CYCLE CHECKPOINT; MORPHOLOGY; NANOENCAPSULATION; NANOPHARMACEUTICS; PARTICLE SIZE; PRIORITY JOURNAL; THERMOGRAVIMETRY; THERMOSTABILITY;

CELL CULTURE TECHNIQUES; CELL CYCLE; CELL SURVIVAL; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DRUG CARRIERS; DRUG COMPOUNDING; ENDOCYTOSIS; FLOW CYTOMETRY; HUMANS; MCF-7 CELLS; MICROSCOPY, FLUORESCENCE; NANOPARTICLES; PACLITAXEL; PARTICLE SIZE; POLYESTERS; POLYGLACTIN 910; SOLUBILITY; SURFACE PROPERTIES; THERMOGRAVIMETRY;

EID: 84865983430     PISSN: 09594973     EISSN: 14735741     Source Type: Journal    
DOI: 10.1097/CAD.0b013e328355a6c6     Document Type: Article

References (50)

1. McGrogan BT, Gilmartin B, Carney DN, McCann A. Taxanes, microtubules and chemoresistant breast cancer. Biochim Biophys Acta 2008; 1785: 96-132.
2. Kim SC, Kim DW, Shim YH, Bang JS, Oh HS, Kim SW, et al. In vivo evaluation of polymeric micellar paclitaxel formulation: Toxicity and efficacy. J Control Release 2001; 72:191-202.
3. Singla AK, Garg A, Aggarwal D. Paclitaxel and its formulations. Int J Pharm 2002; 235:179-192.
4. Irizarry LD, Luu TH, McKoy JM, Samaras AT, Fisher MJ, Carias EE, et al. Cremophor EL-containing paclitaxelinduced anaphylaxis: A call to action. Community Oncol 2009; 6:132-134.
5. Gelderblom H, Verweij J, Nooter K, Sparreboom A. Cremophor EL: The drawbacks and advantages of vehicle selection for drug formulation. Eur J Cancer 2001; 37:1590-1598.
6. Alexis F, Rhee JW, Richie JP, Radovic-Moreno AF, Langer R, Farokhzad OC. New frontiers in nanotechnology for cancer treatment. Urol Oncol 2008; 26:74-85.
7. Fetterly GJ, Robert M, Straubinger RM. Pharmacokinetics of paclitaxelcontaining liposomes in rats. AAPS J 2003; 5:90-100.
8. Liu Y, Pan J, Feng SS. Nanoparticles of lipid monolayer shell and biodegradable polymer core for controlled release of paclitaxel: Effects of surfactants on particles size, characteristics and in vitro performance. Int J Pharm 2010; 395:243-250.
9. Bouquet W, Ceelen W, Fritzinger B, Pattyn P, Peeters M, Remon JP, et al. Paclitaxel/beta-cyclodextrin complexes for hyperthermic peritoneal perfusion - formulation and stability. Eur J Pharm Biopharm 2007; 66:391-397.
10. Bilensoy E, Gü rkaynak O, Ertan M, Sen M, Hincal AA. Development of nonsurfactant cyclodextrin nanoparticles loaded with anticancer drug paclitaxel. J Pharm Sci 2008; 97:1519-1529.
11. Hureaux J, Lagarce F, Gagnadoux F, Clavreul A, Benoit JP, Urban T. The adaptation of lipid nanocapsule formulations for blood administration in animals. Int J Pharm 2009; 379:266-269.
12. Wang J, Liu W, Tu Q, Wang J, Song N, Zhang Y, et al. Folate-decorated hybrid polymeric nanoparticles for chemically and physically combined paclitaxel loading and targeted delivery. Biomacromolecules 2011; 12: 228-234.
13. Jiang X, Sha X, Xin H, Chen L, Gao X, Wang X, et al. Self-aggregated pegylated poly (trimethylene carbonate) nanoparticles decorated with c(RGDyK) peptide for targeted paclitaxel delivery to integrin-rich tumors. Biomaterials 2011; 32:9457-9469.
14. Feng SS. Nanoparticles of biodegradable polymers for new-concept chemotherapy. Expert Rev Med Devices 2004; 1:115-125.
15. Hiljanen-Vainio M, Karjalainen T, Seppä lä J. Biodegradable lactone copolymers. I. Characterization and mechanical behavior of E-caprolactone and lactide copolymers. J Appl Polym Sci 1996; 59:1281-1288.
16. Shive MS, Anderson JM. Biodegradation and biocompatibility of PLA and PLGA microspheres. Adv Drug Deliv Rev 1997; 28:5-24.
17. Mei L, Zhang Y, Zheng Y, Tian G, Song C, Yang D, et al. A novel docetaxelloaded poly (e-caprolactone)/pluronic F68 nanoparticle overcoming multidrug resistance for breast cancer treatment. Nanoscale Res Lett 2009; 4:1530-1539.
18. Prabu P, Chaudhari AA, Ko JA, Dharmaraj N, Park SY, Kim HY, et al. Cellular uptake and in vitro drug release studies on paclitaxel-loaded poly (caprolactone)-grafted dextran copolymeric nanoparticles. Nanobiotechnology 2009; 5:42-49.
19. Prabu P, Chaudhari AA, Dharmaraj N, Khil MS, Park SY, Kim HY. Preparation, characterization, in-vitro drug release and cellular uptake of poly(caprolactone) grafted dextran copolymeric nanoparticles loaded with anticancer drug. J Biomed Mater Res A 2009; 90:1128-1136.
20. Liang C, Yang Y, Ling Y, Huang Y, Li T, Li X. Improved therapeutic effect of folate-decorated PLGA-PEG nanoparticles for endometrial carcinoma. Bioorg Med Chem 2011; 19:4057-4066.
21. Jyothi NV, Prasanna PM, Sakarkar SN, Prabha KS, Ramaiah PS, Srawan GY. Microencapsulation techniques, factors influencing encapsulation efficiency. J Microencapsul 2010; 27:187-197.
22. Kim BS, Kim CS, Lee KM. The intracellular uptake ability of chitosan-coated Poly (D,L-lactide-co-glycolide) nanoparticles. Arch Pharm Res 2008; 31:1050-1054.
23. Limé F, Irgun K. Monodisperse polymeric particles by photoinitiated precipitation polymerization. Macromolecules 2007; 40:1962-1968.
24. Liu J, Chew C, Gan L, TeoW, Gan L. Synthesis of monodisperse polystyrene microlatexes by emulsion polymerization using a polymerizable surfactant. Langmuir 1997; 13:4988-4994.
25. Mu L, Feng SS. Fabrication, characterization and in vitro release of paclitaxel (Taxol) loaded poly (lactic-co-glycolic acid) microspheres prepared by spray drying technique with lipid/cholesterol emulsifiers. J Control Release 2001; 76:239-254.
26. Benoit JP, Courteille F, Thies C. A physiochemical study of the morphology of progesterone-loaded poly(D,L-lactide) microspheres. Int J Pharm 1986; 29:95-102.
27. Yang T, Cui FD, Choi MK, Cho JW, Chung SJ, Shim CK, et al. Enhanced solubility and stability of PEGylated liposomal paclitaxel: In vitro and in vivo evaluation. Int J Pharm 2007; 338:317-326.
28. Ei-Arini SK, Leuenberger H. Modelling of drug release from polymer matrices: Effect of drug loading. Int J Pharm 1995; 121:141-148.
29. Blanco MD, Guerrero S, Teijó n C, Olmo R, Pastrana L, Katime I, et al. Preparation and characterization of nanoparticulate poly (N-isopropylacrylamide) hydrogel for the controlled release of anti-tumour drugs. Polym Int 2008; 57:1215-1225.
30. Siepmann J, Siepmann F. Mathematical modeling of drug delivery. Int J Pharm 2008; 364:328-343.
31. Zhang Z, Lee SH, Gan CW, Feng SS. In vitro and in vivo investigation on PLA-TPGS nanoparticles for controlled and sustained small molecule chemotherapy. Pharm Res 2008; 25:1925-1935.
32. Mosmann T. Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays. J Immunol Methods 1983; 65:55-63.
33. Lo'pez-Gasco P, Iglesias I, Benedí J, Lozano R, Teijo'n JM, Blanco MD. Paclitaxel-loaded polyester nanoparticles prepared by spray-drying technology: In vitro bioactivity evaluation. J Microencapsul 2011; 28:417-429.
34. Jin C, Bai L, Wu H, Song W, Guo G, Dou K. Cytotoxicity of paclitaxel incorporated in PLGA nanoparticles on hypoxic human tumor cells. Pharm Res 2009; 26:1776-1784.
35. Heney M, Alipour M, Vergidis D, Omri A, Mugabe C, Th'ng J, et al. Effectiveness of liposomal paclitaxel against MCF-7 breast cancer cells. Can J Physiol Pharmacol 2010; 88:1172-1180.
36. Feng SS, Mu L,Win KY, Huang G. Nanoparticles of biodegradable polymers for clinical administration of paclitaxel. Curr Med Chem 2004; 11:413-424.
37. Penco M, Sartore L, Bignotti F, D'Antone S, Di Landro L. Thermal properties of a new class of block copolymers based on segments of poly(D,L-lacticglycolic acid) and poly(E-caprolactone). Eur Polym J 2000; 36:901-908.
38. D'Antone S, Bignotti F, Sartore L, D'Amore A, Spagnoli G, Penco M. Thermogravimetric investigation of two classes of block copolymers based on poly(lactic-glycolic acid) and poly(E-caprolactone) or poly(ethylene glycol). Polym Degrad Stabil 2001; 74:119-124.
39. Silva-Jú nior AA, Scarpa MV, Pestana KC, Mercuri LP, De Matos JR, de Oliveira AG. Thermal analysis of biodegradable microparticles containing ciprofloxacin hydrochloride obtained by spray drying technique. Thermochim Acta 2008; 467:91-98.
40. Panyam J, Labhasetwar V. Biodegradable nanoparticles for drug and gene delivery to cells and tissue. Adv Drug Deliv Rev 2003; 55:329-347.
41. Wang YM, Sato H, Adachi I, Horikoshi I. Preparation and characterization of poly(lactic-co-glycolic acid) microsphere for targeted delivery of a novel anticancer agent, Taxol. Chem Pharm Bull (Tokyo) 1996; 44: 1935-1940.
42. Sastre RL, Blanco MD, Teijó n C, Olmo R, Teijo'n JM. Preparation and characterization of 5-fluorouracil-loaded poly(E-caprolactone) microspheres for drug administration. Drug Dev Res 2004; 63:41-53.
43. Blanco MD, Sastre RL, Teijó n C, Olmo R, Teijó n JM. Degradation behaviour of microspheres prepared by spray-drying poly (D,L-lactide) and poly(D,L-lactide-co glycolide) polymers. Int J Pharm 2006; 326: 139-147.
44. Davda J, Labhasetwar V. Characterization of nanoparticles uptake by endothelial cells. Int J Pharm 2002; 233:51-59.
45. Song N, Liu W, Tu Q, Liu R, Zhang Y, Wang J. Preparation and in vitro properties of redox-responsive polymeric nanoparticles for paclitaxel delivery. Colloids Surf B Biointerfaces 2011; 87:454-463.
46. Danhier F, Lecouturier N, Vroman B, Jé rome C, Marchand-Brynaert J, Feron O, et al. Paclitaxel loaded PEGylated PLGA-based nanoparticles: In vitro and in vivo evaluation. J Control Release 2009; 133:11-17.
47. Zhang P, Hu L, Wang Y, Wang J, Feng L, Li Y. Poly (E-caprolactone)-block poly (ethyl ethylene phosphate) micelles for brain-targeting drug delivery: In vitro and in vivo valuation. Pharm Res 2010; 27:2657-2669.
48. Serrano MC, Pagani R, Vallet-Regí M, Pena J, Rá mila A, Izquierdo I, et al. In vitro biocompatibility assessment of poly(E-caprolactone) films using L929 mouse fibroblasts. Biomaterials 2004; 25:5603-5611.
49. Dong Y, Feng SS. Poly(D,L-lactide-co-glycolide) (PLGA) nanoparticles prepared by high pressure homogenization for paclitaxel chemotherapy. Int J Pharm 2007; 342:208-214.
50. Hu FX, Neoh KG, Kang ET. Synthesis and in vitro anti-cancer evaluation of tamoxifen-loaded magnetite/PLLA composite nanoparticles. Biomaterials 2006; 27:5725-5733.