Ethogel topical formulation for increasing the local bioavailability of 5-fluorouracil: A mechanistic study

Anti-Cancer Drugs

Volumn 23, Issue 9, 2012, Pages 923-934

  Puri, Richa ^a   Jain, Subheet ^b  

^a PUNJABI UNIVERSITY   (India)

^b GURU NANAK DEV UNIVERSITY   (India)

Author keywords

5 fluorouracil; antitumor assay using Cytoselect; ethogel; optimization; skin irritation; skin targeting

Indexed keywords

CARBOPOL 934; FLUOROURACIL;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ARTICLE; CELL TRANSFORMATION; COLLOID; CONCENTRATION (PARAMETERS); CONFOCAL LASER MICROSCOPY; CONTROLLED STUDY; DRAIZE TEST; DRUG BIOAVAILABILITY; DRUG FORMULATION; DRUG SOLUTION; DRUG SYNTHESIS; ELASTICITY; ETHOGEL; FLUORESCENCE MICROSCOPY; GEL; HUMAN; HUMAN CELL; INFRARED SPECTROSCOPY; LABORATORY TEST; MALE; NONHUMAN; PH MEASUREMENT; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; RAT; SCANNING ELECTRON MICROSCOPY; SCORING SYSTEM; SKIN IRRITATION; SKIN PENETRATION; TRANSMISSION ELECTRON MICROSCOPY; VISCOSITY;

ACRYLATES; ADMINISTRATION, CUTANEOUS; ANIMALS; ANTIMETABOLITES, ANTINEOPLASTIC; BIOLOGICAL AVAILABILITY; CELL LINE, TUMOR; CELL PROLIFERATION; CELL SURVIVAL; DIFFUSION CHAMBERS, CULTURE; DRUG CARRIERS; DRUG COMPOUNDING; DRUG DELIVERY SYSTEMS; DRUG SCREENING ASSAYS, ANTITUMOR; ELASTICITY; FLUOROURACIL; GELS; HUMANS; MICROSCOPY, CONFOCAL; MICROSCOPY, ELECTRON, SCANNING; MICROSCOPY, ELECTRON, TRANSMISSION; MICROSCOPY, FLUORESCENCE; PERMEABILITY; PHOSPHATIDYLCHOLINES; RATS; SKIN; SKIN ABSORPTION; SKIN IRRITANCY TESTS; SOYBEANS; SPECTROSCOPY, FOURIER TRANSFORM INFRARED; TISSUE DISTRIBUTION; VISCOSITY;

EID: 84865982773     PISSN: 09594973     EISSN: 14735741     Source Type: Journal    
DOI: 10.1097/CAD.0b013e3283534051     Document Type: Article

References (31)

1. Ahmed AH, Soyer HP. Non melanoma skin cancer. Drug Discovery Today 2008; 5:55-62.
2. Wienberg MJ. Topical therapy for actinic keratoses: Current and evolving therapies. Rev Rec Clin Trials 2006; 1:53-60.
3. Mcgillis ST, Fein H. Topical treatment strategies for non-melanoma skin cancer precursor lesion. Semin Cutan Med Surg 2004; 23:174-183.
4. Lowenthal RM, Eaton K. Toxicity of chemotherapy. Hematol Oncol Clin North Am 1996; S10:967-990.
5. Krebs HB. The use of topical 5-fluorouracil in the treatment of genital condylomas. Obstet Gynecol Clin North Am 1987; 14:559-568.
6. Williams AC, Barry BW. Penetration enhancers. Adv Drug Deliv Rev 2004; 56:603-618.
7. Jain S, Tiwary AK, Sapra B, Jain NK. Formulation and evaluation of ethosomes for transdermal delivery of lamuvidine. AAPS PharmSciTech 2007; 8:E1-E9.
8. Ainbinder D, Touitou E. A new approach for skin tumor treatment: From delivery system characterization to in vivo evaluation. Drug Deliv Transl Res 2011; 1:53-65.
9. Liu FT, He R, Gao F, Cui DX, Zhao YD. Modification and transdermal absorption of 5-fluorouracil ethosomes. China Pharmacy 2008; 25:1938-1940.
10. Touitou E, Godin B, Dayan N. Intracellular delivery mediated by ethosomal carrier. J Biomater 2001; 22:3055-3059.
11. Dubey V, Mishra D, Jain NK, Dutta T, Nahar M, Saraf DK. Dermal and transdermal delivery of an anti-psoriatic agent via ethanolic liposomes. J Control Release 2007; 123:148-154.
12. Garg T, Jain S, Singh HP, Sharma A, Tiwary AK. Elastic liposomal formulation for sustained delivery of anti-migraine drug: In vitro characterization and biological evaluation. Drug Dev Ind Pharm 2008; 34:1100-1110.
13. Washington C. Evaluation of the non-sink dialysis method for the measurement of drug release from colloids effect of drug partition. Int J Pharm 1989; 56:71-74.
14. Jain S, Jain P, Umamaheshwari RB, Jain NK. Transfersomes - a novel vesicular carrier for enhanced transdermal delivery: Development, characterization, and performance evaluation. Drug Dev Ind Pharm 2003; 29:1013-1026.
15. Ritger PL, Peppas NA. Modeling of water transport solute release in physiologically sensitive gels. J Control Release 1987; 5:37-40.
16. Mutimier MN, Reffkin C, Hill JA, Marry E, Glickman M. Modern ointment base technology II. J Am Pharm Assoc Sci 1956; 45:212-220.
17. Manufacturer's instructions, Cytoselect 96-well cell transformation assay Kit. Cell Biolabs, San Diego, CA, USA. 18 Draize J, Woodard G, Calvery H. Methods for the study of irritation and toxicity of substance applied to the skin and mucous membranes. J Pharmacol Exp Ther 1944; 82:377-390.
18. Barupal AK, Gupta V, Ramteke S. Preparation and characterization of ethosomes for topical delivery of aceclofenac. Indian J Pharm Sci 2010; 72:582-587.
19. Dayan N, Touitou E. Carriers for skin delivery of trihexyphenidyl HCl: Ethosomes vs. liposomes. Biomaterials 2000; 21:1879-1885.
20. Verma DD, Fahr A. Synergistic penetration effect of ethanol and phospholipids on the topical delivery of cyclosporin A. J Control Release 2004; 97:55-66.
21. Singh HP, Jain S, Kumar A, Tiwary AK. Elastic liposomal formulation for sustained delivery of colchicine: In vitro characterization and in vivo evaluation of anti-gout activity. AAPS J 2009; 11:54-64.
22. Patel J, Patel B, Banwait H, Parmar K, Patel M. Formulation and evaluation of topical aceclofenac gel using different gelling agent. Int J Drug Dev Res 2011; 3:156-164.
23. Apikian M, Goodman G. Intralesional 5-fluorouracil in the treatment of keloid scars. Australas J Dermatol 2004; 45:140-143.
24. Finnin BC, Morgan TM. Transdermal penetration enhancers: Applications, limitations, and potential. J Pharm Sci 1999; 88:955-958.
25. Babita K, Kumar V, Rana V, Jain S, Tiwary AK. Thermotropic and spectroscopic behaviour of skin: Relationship with percutaneous permeation enhancement. Curr Drug Deliv 2006; 3:95-113.
26. Verma P, Pathak K. Therapeutic and cosmeceutical potential of ethosomes: An overview. J Adv Pharm Tech Res 2010; 1:274-282.
27. Yuan F, Qin X, Zhou D, Xiang Q, Wang M, Zhang Z, Huang Y. In vitro cytotoxicity, in vivo biodistribution and antitumor activity of HPMA copolymer-5-fluorouracil conjugates. Eur J Pharm Biopharm 2008; 70:770-776.
28. Bercovitch L. Topical chemotherapy of actinic keratoses of the upper extremity with tretinoin and 5-fluorouracil: A double-blind controlled study. Br J Dermatol 1987; 116:549-552.
29. Jirova D, Liebsch M, Basketter D, Spiller E, Kejlova K, Bendova H, et al. Comparison of human skin irritation and photo-irritation patch test data with cellular in vitro assays and animal in vivo data. Proceedings of the 6th World Congress on Alternatives & Animal Use in the Life Sciences; 21-25 August 2007; Tokyo, Japan, special issue, 359-365.
30. Utreja P, Jain S, Tiwary AK. Localized delivery of paclitaxel using elastic liposomes: Formulation development and evaluation. Drug Delivery 2011; 18:367-376.
31. Fluhr JW, Darlenski R, Angelova I, Tsankov N, Basketter D. Skin irritation and sensitization: Mechanisms and new approaches for risk assessment. Skin Pharmacol Physiol 2008; 21:124-135.