Polycationic gramicidin S analogues with both high antibiotic activity and very low hemolytic activity

Chemical and Pharmaceutical Bulletin

Volumn 60, Issue 9, 2012, Pages 1134-1138

  Tamaki, Makoto ^a   Harada, Takuji ^a   Fujinuma, Kenta ^a   Takanashi, Kazumasa ^a   Shindo, Mitsuno ^b   Kimura, Masahiro ^b   Uchida, Yoshiki ^b  

^a TOHO UNIVERSITY   (Japan)

^b OSAKA SHOIN WOMEN'S UNIVERSITY   (Japan)

Author keywords

Gramicidin S; High antibiotic activity; Low hemolytic activity; Polycationic analogue; Structure activity relationship

Indexed keywords

GRAMICIDIN S; LEUCINE; LYSINE; PHENYLALANINE; PROLINE; SYNTHETIC PEPTIDE;

AMINO ACID SUBSTITUTION; ANIMAL CELL; ANTIBIOTIC RESISTANCE; ANTIMICROBIAL ACTIVITY; ARTICLE; BACILLUS MEGATERIUM; BACILLUS SUBTILIS; BETA SHEET; COLONY FORMING UNIT; DOSE RESPONSE; DRUG STRUCTURE; ERYTHROCYTE MEMBRANE; ESCHERICHIA COLI; HEMOLYSIS; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; PSEUDOMONAS AERUGINOSA; STAPHYLOCOCCUS AUREUS; STAPHYLOCOCCUS EPIDERMIDIS;

ANIMALS; ANTI-BACTERIAL AGENTS; BACTERIA; BACTERIAL INFECTIONS; ERYTHROCYTES; GRAMICIDIN; HEMOLYSIS; SHEEP;

EID: 84865979814     PISSN: 00092363     EISSN: 13475223     Source Type: Journal    
DOI: 10.1248/cpb.c12-00290     Document Type: Article

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