Novel gratisin derivatives with high antimicrobial activity and low hemolytic activity

Bioorganic and Medicinal Chemistry Letters

Volumn 21, Issue 1, 2011, Pages 440-443

  Tamaki, Makoto ^a   Imazeki, Yukie ^a   Shirane, Aya ^a   Fujinuma, Kenta ^a   Shindo, Mitsuno ^b   Kimura, Masahiro ^b   Uchida, Yoshiki ^b  

^a TOHO UNIVERSITY   (Japan)

^b OSAKA SHOIN WOMEN'S UNIVERSITY   (Japan)

Author keywords

Gratisin analogues; High antimicrobial activity; Low hemolytic activity; Structure activity relationship; Synthesis

Indexed keywords

ANTIINFECTIVE AGENT; GRATISIN; UNCLASSIFIED DRUG;

AMINO ACID SUBSTITUTION; ANTIMICROBIAL ACTIVITY; ARTICLE; DRUG CONFORMATION; DRUG STRUCTURE; GRAM NEGATIVE BACTERIUM; GRAM POSITIVE BACTERIUM; HEMOLYSIS; HUMAN; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; STRUCTURE ACTIVITY RELATION;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANTI-INFECTIVE AGENTS; CIRCULAR DICHROISM; HEMOLYSIS; MICROBIAL SENSITIVITY TESTS; PEPTIDES, CYCLIC; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 78650511042     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2010.10.122     Document Type: Article

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